Contributions
Abstract: PB1890
Type: Publication Only
Background
Chronic lymphocytic leukaemia (CLL) is a malignant clonal disorder of B lymphocytes with levels greater than 5 x 10⁹/L (5 x 10³/microliter) involving the bone marrow and peripheral blood. The incidence of CLL increases with age. Upon diagnosis, British Society for Haematology(BSH) recommends that all patients should have specific tests such as full blood count, reticulocyte count, direct antiglobulin test (DAT), immunophenotype, and serum immunoglobulins. In addition to this, screening for hepatitis B and C, TP53 deletion and a baseline CT scan should be done prior to treatment.
Aims
The aim of the audit is to assess the compliance with key aspects of BSH guidelines on diagnostic work up for CLL.
Methods
Electronic records for 32 patients diagnosed with CLL between January 2016 and May 2017 in Royal Albert Edward Infirmary (England) were analysed.
Results
The demographics show a higher proportion of males 59% (19 of 32 patients) compared to females 41% (13 of 32 patients). Similar studies show a male-to-female ratio of 2:1 which is comparable to our results. The mean age at diagnosis was 72 years. 3 patients (9.4%) had haemoglobin levels below 100 g/l of which no patients had a reticulocyte count and direct antiglobulin test done. All 32 patients had an immunophenotype typical of CLL. 8 patients (25%) patients did not have their serum immunoglobulins checked. 3 of 32 patients (9%) received treatment with FCR (Fludarabine, Cyclophosphamide, Rituximab) as first line therapy. Before treatment, all 3 patients had screening for hepatitis B and C, TP53 deletion and baseline CT scan.
Conclusion
We suggest that patients with low haemoglobin levels should have a direct antiglobulin test and reticulocyte count performed. All patients should have their serum immunoglobulins checked. A diagnostic work up and pre-treatment checklist should be designed to guide specialist teams.
Session topic: 6. Chronic lymphocytic leukemia and related disorders - Clinical
Abstract: PB1890
Type: Publication Only
Background
Chronic lymphocytic leukaemia (CLL) is a malignant clonal disorder of B lymphocytes with levels greater than 5 x 10⁹/L (5 x 10³/microliter) involving the bone marrow and peripheral blood. The incidence of CLL increases with age. Upon diagnosis, British Society for Haematology(BSH) recommends that all patients should have specific tests such as full blood count, reticulocyte count, direct antiglobulin test (DAT), immunophenotype, and serum immunoglobulins. In addition to this, screening for hepatitis B and C, TP53 deletion and a baseline CT scan should be done prior to treatment.
Aims
The aim of the audit is to assess the compliance with key aspects of BSH guidelines on diagnostic work up for CLL.
Methods
Electronic records for 32 patients diagnosed with CLL between January 2016 and May 2017 in Royal Albert Edward Infirmary (England) were analysed.
Results
The demographics show a higher proportion of males 59% (19 of 32 patients) compared to females 41% (13 of 32 patients). Similar studies show a male-to-female ratio of 2:1 which is comparable to our results. The mean age at diagnosis was 72 years. 3 patients (9.4%) had haemoglobin levels below 100 g/l of which no patients had a reticulocyte count and direct antiglobulin test done. All 32 patients had an immunophenotype typical of CLL. 8 patients (25%) patients did not have their serum immunoglobulins checked. 3 of 32 patients (9%) received treatment with FCR (Fludarabine, Cyclophosphamide, Rituximab) as first line therapy. Before treatment, all 3 patients had screening for hepatitis B and C, TP53 deletion and baseline CT scan.
Conclusion
We suggest that patients with low haemoglobin levels should have a direct antiglobulin test and reticulocyte count performed. All patients should have their serum immunoglobulins checked. A diagnostic work up and pre-treatment checklist should be designed to guide specialist teams.
Session topic: 6. Chronic lymphocytic leukemia and related disorders - Clinical