Contributions
Abstract: PB2353
Type: Publication Only
Background
Chronic immune trombocytopenic purpura (ITP) is defined as an unexplained isolated thrombocytopenia that persists more than 12 months. Rheumatologic diseases, immunodeficiencies and thyroid diseases may coexist with chronic ITP due to immune dysregulation.
Aims
To investigate the frequency of autoimmune thyroiditis in patients with chronic ITP.
Methods
A total of 142 patients with chronic ITP with a follow up period of more than one year between 1995-2018 were included. Thyroid function tests, thyroid autoantibodies, thyroid ultrasonography were investigated.
Results
Seventy-three were female (51.4%) and 69 were male (48.6%). Mean age of patients was 13.2 ± 5.4 years (range 2.4-28.1 years) and the mean age at diagnosis was 89 ± 51 months (range 2.1-200 months). Thyroid function tests and thyroid autoantibodies were investigated in 129 patients. There was no clinical findings of either hypo / hyperthyroidism in any patient however, at least one value of fT4, TSH, anti TPO,or anti TG values was abnormal in 40 (31%) of investigated cases. Twentynine patients (22.4%) were put on follow-up by pediatric endocrinology department with a diagnosis of Hashimoto thyroiditis. Thyroid hormone replacement therapy was started in one patient. Anti TPO values of 22 patients (15.5%) and Anti-TG values of 18 patients (12.7%) were high. The majority of patients with high thyroid autoantibodies were female (67.5%).
Conclusion
We found that thyroid autoantibody positivity without clinical findings was a common finding in children with chronic ITP. According to a comprehensive study conducted in the USA, AntiTPO positivity is 10.4% and AntiTG positivity is 11.3% in general population. When compared with these rates, the frequency of thyroid autoantibody positivity and autoimmune thyroiditis was higher in children with chronic ITP in our study. As a conclusion hematologists managing children with chronic ITP should be vigilant about the regular evaluation with thyroid function tests and thyroid autoantibodies.
Session topic: 33. Platelets disorders
Keyword(s): Children, Immune thrombocytopenia (ITP), Thrombocytopenia
Abstract: PB2353
Type: Publication Only
Background
Chronic immune trombocytopenic purpura (ITP) is defined as an unexplained isolated thrombocytopenia that persists more than 12 months. Rheumatologic diseases, immunodeficiencies and thyroid diseases may coexist with chronic ITP due to immune dysregulation.
Aims
To investigate the frequency of autoimmune thyroiditis in patients with chronic ITP.
Methods
A total of 142 patients with chronic ITP with a follow up period of more than one year between 1995-2018 were included. Thyroid function tests, thyroid autoantibodies, thyroid ultrasonography were investigated.
Results
Seventy-three were female (51.4%) and 69 were male (48.6%). Mean age of patients was 13.2 ± 5.4 years (range 2.4-28.1 years) and the mean age at diagnosis was 89 ± 51 months (range 2.1-200 months). Thyroid function tests and thyroid autoantibodies were investigated in 129 patients. There was no clinical findings of either hypo / hyperthyroidism in any patient however, at least one value of fT4, TSH, anti TPO,or anti TG values was abnormal in 40 (31%) of investigated cases. Twentynine patients (22.4%) were put on follow-up by pediatric endocrinology department with a diagnosis of Hashimoto thyroiditis. Thyroid hormone replacement therapy was started in one patient. Anti TPO values of 22 patients (15.5%) and Anti-TG values of 18 patients (12.7%) were high. The majority of patients with high thyroid autoantibodies were female (67.5%).
Conclusion
We found that thyroid autoantibody positivity without clinical findings was a common finding in children with chronic ITP. According to a comprehensive study conducted in the USA, AntiTPO positivity is 10.4% and AntiTG positivity is 11.3% in general population. When compared with these rates, the frequency of thyroid autoantibody positivity and autoimmune thyroiditis was higher in children with chronic ITP in our study. As a conclusion hematologists managing children with chronic ITP should be vigilant about the regular evaluation with thyroid function tests and thyroid autoantibodies.
Session topic: 33. Platelets disorders
Keyword(s): Children, Immune thrombocytopenia (ITP), Thrombocytopenia