Contributions
Abstract: PB1967
Type: Publication Only
Background
Aplastic anemia is a kind of disease which occurs in the result of bone marrow stem cell damage which causes a deep inhibition of the hematopoiesis’ three germs in the bone marrow. Aplastic anemia is a quite rare disease, but at the same time it is one of the most severe disorders of hemopoiesis with a mortality rate exceeding 80%. In most cases it occurs among young people.
Aims
We aimed to quantify the incidence, prevalence and survival rate aplastic anemia patients in Armenia and their variation with gender, age, year of diagnosis.
Methods
In this work we included aplastic anemia patients diagnosed within 2005 to 2017. The initial data for this survey have been derived from ambulance/dispensary cards, hospitalization journals, and clinical data from the Registry of Blood Diseases at the R.Yeolyan Hematology Center, Yerevan, Armenia. The data has been supplemented by the data from the Registry of Oncological Diseases of the V. Fanarjyan NCO, as well as from death certificates. The demographic data has been obtained from the National Statistics Board of Republic of Armenia. The obtained data has been statistically analyzed using EPI INFO-2002 program.
Results
A total of 69 cases of aplastic anemia were identified, 41 (59.4%) of whom were male. The overall incidence of aplastic anemia was 1.8 per million inhabitants per year (95%CI 0.9–2.9) and the incidence increased with age. The higher incidence rates were noted in 2008 and 2014 (accordingly 0.25 and 0.29). The sex-specific incidence rates were 2.2 for males and 1.7 for females (ratio 1.29). Patients can be affected at any age, although there is a biphasic age distribution with peaks from 10 to 25 (2.9 per million per year) years and >60 years (1.7 per million per year).
Most of the cases were classified as severe or very severe aplastic anemia. Currently 46.4% of studied patients are alive. Survival rates at 5 and 10 years after the diagnosis were 50% and 37%, respectively. Age and disease severity at the time of diagnosis were associated with a lower survival rate.
Conclusion
This is the first general population study to describe the incidence of AA in Armenia during 2005-2017. It forms the basis for quality assessment of aplastic anemia treatment in Armenia and offers a unique opportunity for population-based research. The incidence of aplastic anemia in Armenia is low but the case fatality rate is high. Advanced age and severe disease at the time of diagnosis were associated with decreased survival.
Session topic: 29. Enzymopathies, membranopathies and other anemias
Keyword(s): Aplastic anemia, Incidence, Survival
Abstract: PB1967
Type: Publication Only
Background
Aplastic anemia is a kind of disease which occurs in the result of bone marrow stem cell damage which causes a deep inhibition of the hematopoiesis’ three germs in the bone marrow. Aplastic anemia is a quite rare disease, but at the same time it is one of the most severe disorders of hemopoiesis with a mortality rate exceeding 80%. In most cases it occurs among young people.
Aims
We aimed to quantify the incidence, prevalence and survival rate aplastic anemia patients in Armenia and their variation with gender, age, year of diagnosis.
Methods
In this work we included aplastic anemia patients diagnosed within 2005 to 2017. The initial data for this survey have been derived from ambulance/dispensary cards, hospitalization journals, and clinical data from the Registry of Blood Diseases at the R.Yeolyan Hematology Center, Yerevan, Armenia. The data has been supplemented by the data from the Registry of Oncological Diseases of the V. Fanarjyan NCO, as well as from death certificates. The demographic data has been obtained from the National Statistics Board of Republic of Armenia. The obtained data has been statistically analyzed using EPI INFO-2002 program.
Results
A total of 69 cases of aplastic anemia were identified, 41 (59.4%) of whom were male. The overall incidence of aplastic anemia was 1.8 per million inhabitants per year (95%CI 0.9–2.9) and the incidence increased with age. The higher incidence rates were noted in 2008 and 2014 (accordingly 0.25 and 0.29). The sex-specific incidence rates were 2.2 for males and 1.7 for females (ratio 1.29). Patients can be affected at any age, although there is a biphasic age distribution with peaks from 10 to 25 (2.9 per million per year) years and >60 years (1.7 per million per year).
Most of the cases were classified as severe or very severe aplastic anemia. Currently 46.4% of studied patients are alive. Survival rates at 5 and 10 years after the diagnosis were 50% and 37%, respectively. Age and disease severity at the time of diagnosis were associated with a lower survival rate.
Conclusion
This is the first general population study to describe the incidence of AA in Armenia during 2005-2017. It forms the basis for quality assessment of aplastic anemia treatment in Armenia and offers a unique opportunity for population-based research. The incidence of aplastic anemia in Armenia is low but the case fatality rate is high. Advanced age and severe disease at the time of diagnosis were associated with decreased survival.
Session topic: 29. Enzymopathies, membranopathies and other anemias
Keyword(s): Aplastic anemia, Incidence, Survival