Contributions
Abstract: PB2186
Type: Publication Only
Background
Multiple Myeloma (MM) patients with bone destruction is difficult to restore, so deeply explore the factors affected the bone destruction associated with MM will be important in clinic. This study retrospectively analyzed 419 cases with multiple myeloma.
Aims
In this study, the factors correlated with bone destruction and factors affecting survival and prognosis of myeloma bone destruction were analyzed by a retrospective study.
Methods
Comparison between categorical variables was made by the chi-square analysis with pearson test. The parametric t test with independent samples was used to compare the mean of variables between without bone destruction and with bone destruction patients. Correlation was analyzed using bivariate correlation analysis by pearson test (r). The multivariate analysis that factors associated with bone destruction were determined by binary logistic regression model with forward stepwise. The survival analysis was evaluated according to the Kaplan-Meier method with the two-sided log-rank test
Results
Multiple linear regression analysis showed that those MM patients with higher concentration of Ca2+ in serum, higher positive rate of CD138 immuno-phenotype and advanced in stage with 13q34 deletion in cytogenetics would more prone to bone destruction, while total bile acid (TBA) and Kappa chain isotope negatively correlated with bone destruction in MM patients. The Kaplan-Meier analysis indicated that Ca2+, serum β2-microglobulin (β2-MG), hemoglobin (HGB), creatinine (CREA), uric acid (UA) and age correlated with the survival of bone destruction in MM patients. Cox regression analysis further showed that the independent prognostic factors of β2-MG and CREA had higher risk for early mortality in bone destruction patients. Moreover, a novel index based on β2-MG and globulin (GLB) to white blood cell (WBC) ratio were associated with high-risk and predicted poor survival of bone destruction patients, which will be a novel index predicts prognosis of myeloma patients using routine examination method instead of bone marrow aspiration and has an important significance for clinical guide.
Conclusion
In a conclusion, for MM patients, those with higher concentration of Ca2+ in serum, higher positive rate of CD138 immuno-phenotype and advanced in Stage with 13q34 deletion in cytogenetics would more prone to bone destruction. Hypercalcaemia, elevated serum β2-MG, anemia, renal insufficiency, elevated UA and advanced in years were correlated with poor survival and high risk in bone destruction of multiple myeloma. Combined β2-MG, GLB and WBC significantly predicts prognosis of bone destruction patients, which will be an important significance for clinical guide.
Session topic: 14. Myeloma and other monoclonal gammopathies - Clinical
Keyword(s): Multiple Myeloma, Survival
Abstract: PB2186
Type: Publication Only
Background
Multiple Myeloma (MM) patients with bone destruction is difficult to restore, so deeply explore the factors affected the bone destruction associated with MM will be important in clinic. This study retrospectively analyzed 419 cases with multiple myeloma.
Aims
In this study, the factors correlated with bone destruction and factors affecting survival and prognosis of myeloma bone destruction were analyzed by a retrospective study.
Methods
Comparison between categorical variables was made by the chi-square analysis with pearson test. The parametric t test with independent samples was used to compare the mean of variables between without bone destruction and with bone destruction patients. Correlation was analyzed using bivariate correlation analysis by pearson test (r). The multivariate analysis that factors associated with bone destruction were determined by binary logistic regression model with forward stepwise. The survival analysis was evaluated according to the Kaplan-Meier method with the two-sided log-rank test
Results
Multiple linear regression analysis showed that those MM patients with higher concentration of Ca2+ in serum, higher positive rate of CD138 immuno-phenotype and advanced in stage with 13q34 deletion in cytogenetics would more prone to bone destruction, while total bile acid (TBA) and Kappa chain isotope negatively correlated with bone destruction in MM patients. The Kaplan-Meier analysis indicated that Ca2+, serum β2-microglobulin (β2-MG), hemoglobin (HGB), creatinine (CREA), uric acid (UA) and age correlated with the survival of bone destruction in MM patients. Cox regression analysis further showed that the independent prognostic factors of β2-MG and CREA had higher risk for early mortality in bone destruction patients. Moreover, a novel index based on β2-MG and globulin (GLB) to white blood cell (WBC) ratio were associated with high-risk and predicted poor survival of bone destruction patients, which will be a novel index predicts prognosis of myeloma patients using routine examination method instead of bone marrow aspiration and has an important significance for clinical guide.
Conclusion
In a conclusion, for MM patients, those with higher concentration of Ca2+ in serum, higher positive rate of CD138 immuno-phenotype and advanced in Stage with 13q34 deletion in cytogenetics would more prone to bone destruction. Hypercalcaemia, elevated serum β2-MG, anemia, renal insufficiency, elevated UA and advanced in years were correlated with poor survival and high risk in bone destruction of multiple myeloma. Combined β2-MG, GLB and WBC significantly predicts prognosis of bone destruction patients, which will be an important significance for clinical guide.
Session topic: 14. Myeloma and other monoclonal gammopathies - Clinical
Keyword(s): Multiple Myeloma, Survival