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NON-HEMOLYTIC FEBRILE POST-PLATELET-TRANSFUSION REACTIONS IN HEMATOLOGICAL PATIENTS.
Author(s):
Angelika Rakhmani
,
Angelika Rakhmani
Affiliations:
Clinical Research Department of processing and cryopreservation of blood cells,Federal State-Funded Institution National Research Center for Hematology of the Ministry of Healthcare of the Russian Federation,Moscow,Russian Federation
Elena Mikhaylova
,
Elena Mikhaylova
Affiliations:
Clinical Research department of chemotherapy and bone marrow depression,Federal State-Funded Institution National Research Center for Hematology of the Ministry of Healthcare of the Russian Federation,Moscow,Russian Federation
Igor Dubinkin
,
Igor Dubinkin
Affiliations:
Scientific clinical laboratory quality control and safety of transfusions,Federal State-Funded Institution National Research Center for Hematology of the Ministry of Healthcare of the Russian Federation,Moscow,Russian Federation
Vera Troitskaya
,
Vera Troitskaya
Affiliations:
Clinical Research department of chemotherapy and bone marrow depression,Federal State-Funded Institution National Research Center for Hematology of the Ministry of Healthcare of the Russian Federation,Moscow,Russian Federation
Olga Kalmikova
,
Olga Kalmikova
Affiliations:
Scientific clinical laboratory quality control and safety of transfusions,Federal State-Funded Institution National Research Center for Hematology of the Ministry of Healthcare of the Russian Federation,Moscow,Russian Federation
Maria Danilevskaya
,
Maria Danilevskaya
Affiliations:
Scientific clinical laboratory quality control and safety of transfusions,Federal State-Funded Institution National Research Center for Hematology of the Ministry of Healthcare of the Russian Federation,Moscow,Russian Federation
Tatjana Gaponova
Tatjana Gaponova
Affiliations:
Clinical Research Department of processing and cryopreservation of blood cells,Federal State-Funded Institution National Research Center for Hematology of the Ministry of Healthcare of the Russian Federation,Moscow,Russian Federation
(Abstract release date: 05/18/17) EHA Library. Rakhmani A. 05/18/17; 182945; PB2232
Angelika Rakhmani
Angelika Rakhmani
Contributions
PDF Abstract
Abstract

Abstract: PB2232

Type: Publication Only

Background
Platelet concentrate (PC) transfusions are the main method of thrombocytopenia correction in hematological patients, but multiple transfusions could trigger alloimmunity and refractoriness to transfusions.

Aims

Comparison of post-transfusion reactions in hematological patients with individual matching and without individual matching receiving PC transfusion support.

Methods

In 2015-2016, we observed 948 hospitalized patients, who received 12.344 PC transfusions. Individual matching of PCs was performed by cross-matching on the Galileo-Neo (Immucor) analyzer. Statistical processing was performed using the chi-squared test with Yates’ correction.

Results

107 of 948 patients developed refractoriness to PC transfusions (12% of total patients). Out of them, 21 patients received 389 PC transfusions without individual matching. 86 patients received 1705 PC transfusions with individual matching.
During transfusions without individual matching to non-refractory patients, 0.003% of non-hemolytic febrile reactions (NHFR) have been recorded, after matching to refractory patients the frequency was 0.002%. Before matching to refractory patients, the frequency of NHFR was (0.03%).

Conclusion

The frequency of NHFR in groups with refractoriness with individual matching is significantly lower (10 fold) compared to groups with refractoriness before the matching (Р<0,01)*.

Session topic: 30. Transfusion medicine

Keyword(s): transfusion, Refractory, Platelet transfusion

Abstract: PB2232

Type: Publication Only

Background
Platelet concentrate (PC) transfusions are the main method of thrombocytopenia correction in hematological patients, but multiple transfusions could trigger alloimmunity and refractoriness to transfusions.

Aims

Comparison of post-transfusion reactions in hematological patients with individual matching and without individual matching receiving PC transfusion support.

Methods

In 2015-2016, we observed 948 hospitalized patients, who received 12.344 PC transfusions. Individual matching of PCs was performed by cross-matching on the Galileo-Neo (Immucor) analyzer. Statistical processing was performed using the chi-squared test with Yates’ correction.

Results

107 of 948 patients developed refractoriness to PC transfusions (12% of total patients). Out of them, 21 patients received 389 PC transfusions without individual matching. 86 patients received 1705 PC transfusions with individual matching.
During transfusions without individual matching to non-refractory patients, 0.003% of non-hemolytic febrile reactions (NHFR) have been recorded, after matching to refractory patients the frequency was 0.002%. Before matching to refractory patients, the frequency of NHFR was (0.03%).

Conclusion

The frequency of NHFR in groups with refractoriness with individual matching is significantly lower (10 fold) compared to groups with refractoriness before the matching (Р<0,01)*.

Session topic: 30. Transfusion medicine

Keyword(s): transfusion, Refractory, Platelet transfusion

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