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THE POLICY AND PRACTICE OF ANTICOAGULATION THERAPY AMONG CLINICIANS IN SOUTHEAST NIGERIA.
Author(s): ,
Theresa U Nwagha
Affiliations:
Haematology & Immunology,University Of Nigeria Teaching Hospital,Enugu,Nigeria
,
Ralph Anakwue
Affiliations:
Internal medicine,University Of Nigeria Teaching Hospital,Enugu,Nigeria
,
Oju Ukpabi
Affiliations:
Internal medicine,Abia state Teaching Hospital,Umuahia,Nigeria
,
E Onwubuya
Affiliations:
Internal medicine,Nnamdi Azikiwe Teaching Hospital Nnewi,Awka,Nigeria
,
N Obeka
Affiliations:
Internal medicine,Federal Medical center, Abakiliki,Nigeria
,
Innocent Okoye
Affiliations:
Internal medicine,Amaku Specialist hospital,Awka,Nigeria
Ben Azubuike
Affiliations:
Internal medicine,Amaku Specialist hospital,Awka,Nigeria
(Abstract release date: 05/18/17) EHA Library. Nwagha T. 05/18/17; 182940; PB2227
Prof. Theresa Nwagha
Prof. Theresa Nwagha
Contributions
Abstract

Abstract: PB2227

Type: Publication Only

Background
In the absence of anticoagulation therapy, the risk of Venous thromboembolism; deep-vein thrombosis (DVT) and pulmonary embolism(PE)in medically ill patients is comparable to that in moderate-risk surgical patients. Previous studies have revealed grossly inadequate knowledge and a dismal practice of anticoagulation among healthcare workers in some resource poor countries. Prophylactic anticoagulation is under-prescribed in Nigeria, South Africa, as well as in many other countries in Africa.

Aims
The aims of the study are to evaluate the practice of anticoagulant therapy. It will also document the frequency of drug-induced complications resulting from the use of anticoagulants and presence of an anticoagulation policy in the hospitals surveyed.

Methods

This is a multicentre cohort survey of the practice of anticoagulant therapy among clinicians in South East Nigeria. A pretested validated questionnaire was administered to clinicians in five tertiary hospitals in the southeast of Nigeria. The questionnaire was designed to assess their practices anticoagulation therapy. The questionnaire was administered consecutively on clinicians in the participating centers. The following institutions participated in the survey: University of Nigeria Teaching Hospital Enugu, Federal Medical Centre, Abakaliki, Federal Medical Centre Umuahia, Abia State Teaching Hospital, Aba and Amaku Specialist hospital Awka. Statistical package for Social Science (SPSS) software, version 18 (SPSS Inc., Chicago, IL) was used for analysis.

Results
A total of 528 clinicians were involved in the survey. There were more males 378 (71.6% ) than females, 150 (28.4%) the clinicians who practiced for less than 5years are in the majority 189 (35.8% ) and those with 15-20 years of practice 46(8.7%) are in the minority. Only 52 of the respondents (9.8%) claimed their institutions had an anticoagulation policy while 274 (51.9% ) of them said there was no such policy and 168 (31.2% ) do not know of any policy. Unfractionated heparin was the most frequently used (96.8%) and fondaparinux was the most infrequently used (42%). Most of the prescriptions were done by younger clinicians who are the highest in number. The consultants prescribed heparin and warfarin most, with the newer anticoagulants taking the rear position. Only 193 (36.6%) of the respondents routinely prescribed anticoagulation therapy when indicated. 412(78%) of respondents believe the risk of anticoagulation outweighs the benefits while 439 (83.1 %) identified cost is an important variable in prescribing anticoagulation agent. Anti-coagulation prophylaxis was the most frequently used for patients immobilized or bedridden (94.1%); malignancy and atrial fibrillation were the most infrequent reasons for using anticoagulation agents (50.6%) . A total of 63 respondents (11.9%) were not satisfied and 219 (41.5%) were not very satisfied with the laboratory monitoring tool available in their institutions. Bleeding is the most common complication of anticoagulation while the least encountered complications are skin and jaw necrosis among the respondents 492(93.2%), 1(0.2%) respectively

Conclusion
This survey has shown the lack of anticoagulation policies among the centers that participated. Our survey has also shown deficiencies in the areas of practice of anticoagulation among the clinicians in the Southeast of Nigeria. These gaps can be remedied by continuous medical education and by the establishment of anticoagulation policies.

Session topic: 34. Thrombosis and vascular biology

Keyword(s): Medical patients, Anticoagulation, Venous thromboembolism

Abstract: PB2227

Type: Publication Only

Background
In the absence of anticoagulation therapy, the risk of Venous thromboembolism; deep-vein thrombosis (DVT) and pulmonary embolism(PE)in medically ill patients is comparable to that in moderate-risk surgical patients. Previous studies have revealed grossly inadequate knowledge and a dismal practice of anticoagulation among healthcare workers in some resource poor countries. Prophylactic anticoagulation is under-prescribed in Nigeria, South Africa, as well as in many other countries in Africa.

Aims
The aims of the study are to evaluate the practice of anticoagulant therapy. It will also document the frequency of drug-induced complications resulting from the use of anticoagulants and presence of an anticoagulation policy in the hospitals surveyed.

Methods

This is a multicentre cohort survey of the practice of anticoagulant therapy among clinicians in South East Nigeria. A pretested validated questionnaire was administered to clinicians in five tertiary hospitals in the southeast of Nigeria. The questionnaire was designed to assess their practices anticoagulation therapy. The questionnaire was administered consecutively on clinicians in the participating centers. The following institutions participated in the survey: University of Nigeria Teaching Hospital Enugu, Federal Medical Centre, Abakaliki, Federal Medical Centre Umuahia, Abia State Teaching Hospital, Aba and Amaku Specialist hospital Awka. Statistical package for Social Science (SPSS) software, version 18 (SPSS Inc., Chicago, IL) was used for analysis.

Results
A total of 528 clinicians were involved in the survey. There were more males 378 (71.6% ) than females, 150 (28.4%) the clinicians who practiced for less than 5years are in the majority 189 (35.8% ) and those with 15-20 years of practice 46(8.7%) are in the minority. Only 52 of the respondents (9.8%) claimed their institutions had an anticoagulation policy while 274 (51.9% ) of them said there was no such policy and 168 (31.2% ) do not know of any policy. Unfractionated heparin was the most frequently used (96.8%) and fondaparinux was the most infrequently used (42%). Most of the prescriptions were done by younger clinicians who are the highest in number. The consultants prescribed heparin and warfarin most, with the newer anticoagulants taking the rear position. Only 193 (36.6%) of the respondents routinely prescribed anticoagulation therapy when indicated. 412(78%) of respondents believe the risk of anticoagulation outweighs the benefits while 439 (83.1 %) identified cost is an important variable in prescribing anticoagulation agent. Anti-coagulation prophylaxis was the most frequently used for patients immobilized or bedridden (94.1%); malignancy and atrial fibrillation were the most infrequent reasons for using anticoagulation agents (50.6%) . A total of 63 respondents (11.9%) were not satisfied and 219 (41.5%) were not very satisfied with the laboratory monitoring tool available in their institutions. Bleeding is the most common complication of anticoagulation while the least encountered complications are skin and jaw necrosis among the respondents 492(93.2%), 1(0.2%) respectively

Conclusion
This survey has shown the lack of anticoagulation policies among the centers that participated. Our survey has also shown deficiencies in the areas of practice of anticoagulation among the clinicians in the Southeast of Nigeria. These gaps can be remedied by continuous medical education and by the establishment of anticoagulation policies.

Session topic: 34. Thrombosis and vascular biology

Keyword(s): Medical patients, Anticoagulation, Venous thromboembolism

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