HAEMATOLOGICAL CORRELATES OF ISCHEMIC STROKE AND TRANSIENT ISCHEMIC ATTACK : LESSONS LEARNED
(Abstract release date: 05/18/17)
EHA Library. Gunasekara H. 05/18/17; 182929; PB2216
Himali Gunasekara
Contributions
Contributions
Abstract
Abstract: PB2216
Type: Publication Only
Background
Haematological abnormalities are known to cause Ischemic Stroke or Transient Ischemic Attack (TIA). The identification of haematological correlates plays an important role in management and secondary prevention
Aims
The objective of this study was to describe haematological correlates of stroke and their association between stroke profile. The haematological correlates screened were Lupus Anticoagulant, Dysfibroginemia, Paroxysmal nocturnal haemoglobinurea (PNH), Sickle cell disease, Systemic Lupus Erythematosis (SLE) and Myeloploriferative Neoplasms (MPN).
Methods
A cross sectional descriptive study was conducted in a sample of 152 stroke patients referred to haematology department of National Hospital of Sri Lanka for thrombophilia screening. Following tests were performed to assess each hematological correlates.
Hematological correlate | Tests performed |
Lupus anticoagulant | Diluted Russels Viper Venom Test and Kaolin clotting time |
Sickle cell disease | Full blood count (FBC), blood picture and sickling test and High Performance Liquid Chromatography |
Paroxysmal nocturnal haemoglobinurea | FBC, blood picture, Ham test and flowcytometry |
Myeloploriferative neoplasms | FBC, blood picture, Janus Kinase 2 (V617F) mutation analysis, erythropoietin level and bone marrow examination |
Dysfibrinogenaemia | TT, fibrinogen antigen test, clot observation and clauss test |
Systemic lupus erythematosis | Anti nuclear antibodies |
Results
Among study sample, 134 patients had strokes and only 18 had TIA. The recurrence of stroke/TIA was observed in 13.2% of patients. The majority of patients (94.7%) have had radiological evidence of thrombotic event. One fourth of patients had past thrombotic events while 12.5% had family history of thrombosis. Out of haematological correlates screened Lupus anticoagulant was the most common haematological correlate (n=16 ) and dysfibrigonaemia(n=11 ) had the next high prevalence. One patient was diagnosed with Essential thrombocythaemia and one with SLE. None of the patients were positive for screening tests done for sickle cell disease and PNH.
Conclusion
The Haematological correlates were identified in 19% of our study sample. Among stroke profile only presence of past thrombotic history was statistically significantly associated with haematological disorders (P= 0.04). Therefore hematological disorders appear to be an important factor in etiological work up of stroke patients particularly in patients with past thrombotic events.
Session topic: 34. Thrombosis and vascular biology
Keyword(s): Stroke
Abstract: PB2216
Type: Publication Only
Background
Haematological abnormalities are known to cause Ischemic Stroke or Transient Ischemic Attack (TIA). The identification of haematological correlates plays an important role in management and secondary prevention
Aims
The objective of this study was to describe haematological correlates of stroke and their association between stroke profile. The haematological correlates screened were Lupus Anticoagulant, Dysfibroginemia, Paroxysmal nocturnal haemoglobinurea (PNH), Sickle cell disease, Systemic Lupus Erythematosis (SLE) and Myeloploriferative Neoplasms (MPN).
Methods
A cross sectional descriptive study was conducted in a sample of 152 stroke patients referred to haematology department of National Hospital of Sri Lanka for thrombophilia screening. Following tests were performed to assess each hematological correlates.
Hematological correlate | Tests performed |
Lupus anticoagulant | Diluted Russels Viper Venom Test and Kaolin clotting time |
Sickle cell disease | Full blood count (FBC), blood picture and sickling test and High Performance Liquid Chromatography |
Paroxysmal nocturnal haemoglobinurea | FBC, blood picture, Ham test and flowcytometry |
Myeloploriferative neoplasms | FBC, blood picture, Janus Kinase 2 (V617F) mutation analysis, erythropoietin level and bone marrow examination |
Dysfibrinogenaemia | TT, fibrinogen antigen test, clot observation and clauss test |
Systemic lupus erythematosis | Anti nuclear antibodies |
Results
Among study sample, 134 patients had strokes and only 18 had TIA. The recurrence of stroke/TIA was observed in 13.2% of patients. The majority of patients (94.7%) have had radiological evidence of thrombotic event. One fourth of patients had past thrombotic events while 12.5% had family history of thrombosis. Out of haematological correlates screened Lupus anticoagulant was the most common haematological correlate (n=16 ) and dysfibrigonaemia(n=11 ) had the next high prevalence. One patient was diagnosed with Essential thrombocythaemia and one with SLE. None of the patients were positive for screening tests done for sickle cell disease and PNH.
Conclusion
The Haematological correlates were identified in 19% of our study sample. Among stroke profile only presence of past thrombotic history was statistically significantly associated with haematological disorders (P= 0.04). Therefore hematological disorders appear to be an important factor in etiological work up of stroke patients particularly in patients with past thrombotic events.
Session topic: 34. Thrombosis and vascular biology
Keyword(s): Stroke
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