Contributions
Abstract: PB2206
Type: Publication Only
Background
Aims
The aim of the study is to assess the APLS and HbA1c levels and evaluate the correlation between APLS levels and HBA1c in T2DM patients with diabetic vascular complications.
Methods
This was a cross-sectional study of subjects with T2DM attending the diabetic clinic of University of Nigeria Teaching Hospital. A total of two hundred and ten (210) subjects were recruited for this study. There were grouped into three (complicated T2DM, uncomplicated T2DM and health control. Each had 70 subjects matched for sex and age. Lupus anticoagulant (LA) was assayed using DRVVT (technoclone GmbH Austria) IgGβ2GPI-ACA was assayed using ELISA test kit (Genway Bio-tech San Diego USA), HbA1C was assayed using D10TM haemoglobin analyzer. Ethical clearance was obtained from ethical committee UNTH.
Results
The prevalence of LA was 7.1%, 4.3% and 4.3% for complicated T2DM, uncomplicated and healthy control subjects respectively, while the prevalence of IgG-B2GPI ACA was 4.3% in all groups. The mean HbA1C were 8.2(1.5), 8.0 (1.7), 5.6 (0.38) for complicated, uncomplicated T2DM and control subjects respectively. ANOVA showed a significance difference in mean HbA1C among complicated uncomplicated T2DM and healthy controls. Post hoc analysis showed this difference was between complicated T2DM and healthy controls (p<0.001, 95%,CI-3.0 to -2.1) and in uncomplicated T2DM and healthy control subjects (p<0.001,95%,CL-2.8 to -2.0) there was a significant correlation between HbA1C and IgGβ2GPI-ACA for complicated T2DM(r=0.316),P=0.008) and uncomplicated T2DM (r=0.316),P<0.001)
Conclusion
The study did not find any causal or other association between T2DM and the occurrence of APLS positivity, however, APLS may be simply an aggravating factor for vascular complications especially in poor controlled T2DM
Session topic: 34. Thrombosis and vascular biology
Keyword(s): APL
Abstract: PB2206
Type: Publication Only
Background
Aims
The aim of the study is to assess the APLS and HbA1c levels and evaluate the correlation between APLS levels and HBA1c in T2DM patients with diabetic vascular complications.
Methods
This was a cross-sectional study of subjects with T2DM attending the diabetic clinic of University of Nigeria Teaching Hospital. A total of two hundred and ten (210) subjects were recruited for this study. There were grouped into three (complicated T2DM, uncomplicated T2DM and health control. Each had 70 subjects matched for sex and age. Lupus anticoagulant (LA) was assayed using DRVVT (technoclone GmbH Austria) IgGβ2GPI-ACA was assayed using ELISA test kit (Genway Bio-tech San Diego USA), HbA1C was assayed using D10TM haemoglobin analyzer. Ethical clearance was obtained from ethical committee UNTH.
Results
The prevalence of LA was 7.1%, 4.3% and 4.3% for complicated T2DM, uncomplicated and healthy control subjects respectively, while the prevalence of IgG-B2GPI ACA was 4.3% in all groups. The mean HbA1C were 8.2(1.5), 8.0 (1.7), 5.6 (0.38) for complicated, uncomplicated T2DM and control subjects respectively. ANOVA showed a significance difference in mean HbA1C among complicated uncomplicated T2DM and healthy controls. Post hoc analysis showed this difference was between complicated T2DM and healthy controls (p<0.001, 95%,CI-3.0 to -2.1) and in uncomplicated T2DM and healthy control subjects (p<0.001,95%,CL-2.8 to -2.0) there was a significant correlation between HbA1C and IgGβ2GPI-ACA for complicated T2DM(r=0.316),P=0.008) and uncomplicated T2DM (r=0.316),P<0.001)
Conclusion
The study did not find any causal or other association between T2DM and the occurrence of APLS positivity, however, APLS may be simply an aggravating factor for vascular complications especially in poor controlled T2DM
Session topic: 34. Thrombosis and vascular biology
Keyword(s): APL