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ADIPOSE TISSUE CHANGES IN LYMPHOMA PATIENTS IN THE PERI TRANSPLANTATION PHASE
Author(s):
Jana Jabbour
,
Jana Jabbour
Affiliations:
Clinical Nutrition,American University of Beirut Medical Center,Beirut,Lebanon;Ecole Doctorale Sciences de la vie et de la santé,Aix Marseille Université,Marseille,France
Batoul Manana
,
Batoul Manana
Affiliations:
Division of Hematology/Oncology,American University of Beirut Medical Center,Beirut,Lebanon
Ammar Zahreddine
,
Ammar Zahreddine
Affiliations:
Bone Marrow Transplantation Program,American University of Beirut Medical Center,Beirut,Lebanon
Charbel Saadeh
,
Charbel Saadeh
Affiliations:
Department of Radiology, American University of Beirut Medical Center, Beirut, Lebanon,American University of Beirut Medical Center,Beirut,Lebanon
Charafeddine Maya
,
Charafeddine Maya
Affiliations:
Division of Hematology/Oncology,American University of Beirut Medical Center,Beirut,Lebanon
Ali Bazarbachi
,
Ali Bazarbachi
Affiliations:
Bone Marrow Transplantation Program,American University of Beirut Medical Center,Beirut,Lebanon
Didier Blaise
,
Didier Blaise
Affiliations:
Programme de Transplantation et Thérapie Cellulaire,Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes,Marseille,France
Jean El Cheikh
Jean El Cheikh
Affiliations:
Division of Hematology/Oncology,American University of Beirut Medical Center,Beirut,Lebanon
(Abstract release date: 05/18/17) EHA Library. El Cheikh J. 05/18/17; 182890; PB2177
Jean El Cheikh
Jean El Cheikh
Contributions
PDF Abstract
Abstract

Abstract: PB2177

Type: Publication Only

Background

Abdominal Visceral Adipose Tissues (VAT) have been shown to have inflammatory activity and have been used to predict cancer outcomes. The ratio of VAT/Total Adipose Tissues (TAT) is a negative predictor of progression free survival in Lymphoma patients on chemotherapy.

Aims

Assess the changes in adipose tissues among stem cell lymphoma recipients in the peri-transplantation phase.

Methods
Institutional Review Board approved this retrospective study for adult patients (age> 16 years) having B and T lymphoma who underwent Stem Cell Transplantation (SCT). Each patient was imaged by PET/CT scan pre-SCT and in the first 3 months post transplantation. A cross sectional image was analyzed at the level of the L3 to calculate TAT, VAT and Waist Circumference (WC). Data was analyzed by gender since body composition parameters differed significantly between the two categories in the literature.

Results

The study sample consisted of 91 patients [mean age: 37.7 ± 13.5 years, n=52 (57%) males, n=81(87%) autologous SCT, n=12(13%) allogeneic SCT, median overall survival in months: 12 in males and 19 in females]. Death was observed in 6 (11.5%) males and 1(2.4%) female.
Patient characteristics were similar across gender categories except for weights (kg) and Body Mass Index (kg/m2): 88.1 and 28.6 vs 65.2 and 25.0, in males and females respectively (p<0.05). Changes from pre-SCT to 3 months post SCT revealed that TAT and VAT decreased with mean differences of 33 ± 56 cm2 (p<0.01) and 7.0 ± 36 cm2 (p=0.17) in males and 16 ± 44 cm2 (p<0.01) and 4 ± 14 cm2 (p=0.056) in females, respectively. Waist circumference decreased significantly with mean differences of 3.9 ± 4.9 cm and 2.8 ± 4.4 cm in males and females, respectively (p<0.01). VAT/TAT withnissed a slight increase in males and reduction in females (p>0.05). In multivariate analysis, no significant associations were shown with mortality and progression rates.

Conclusion

This study provides data on the evolution of adipose tissues parameters in the peri-transplantation phase. TAT, VAT and WC decrease 3 months post transplantation. Future studies should evaluate the associations of these parameters with major outcomes on larger sample sizes.

Session topic: 22. Stem cell transplantation - Clinical

Keyword(s): Stem cell transplant, lymphoma

Abstract: PB2177

Type: Publication Only

Background

Abdominal Visceral Adipose Tissues (VAT) have been shown to have inflammatory activity and have been used to predict cancer outcomes. The ratio of VAT/Total Adipose Tissues (TAT) is a negative predictor of progression free survival in Lymphoma patients on chemotherapy.

Aims

Assess the changes in adipose tissues among stem cell lymphoma recipients in the peri-transplantation phase.

Methods
Institutional Review Board approved this retrospective study for adult patients (age> 16 years) having B and T lymphoma who underwent Stem Cell Transplantation (SCT). Each patient was imaged by PET/CT scan pre-SCT and in the first 3 months post transplantation. A cross sectional image was analyzed at the level of the L3 to calculate TAT, VAT and Waist Circumference (WC). Data was analyzed by gender since body composition parameters differed significantly between the two categories in the literature.

Results

The study sample consisted of 91 patients [mean age: 37.7 ± 13.5 years, n=52 (57%) males, n=81(87%) autologous SCT, n=12(13%) allogeneic SCT, median overall survival in months: 12 in males and 19 in females]. Death was observed in 6 (11.5%) males and 1(2.4%) female.
Patient characteristics were similar across gender categories except for weights (kg) and Body Mass Index (kg/m2): 88.1 and 28.6 vs 65.2 and 25.0, in males and females respectively (p<0.05). Changes from pre-SCT to 3 months post SCT revealed that TAT and VAT decreased with mean differences of 33 ± 56 cm2 (p<0.01) and 7.0 ± 36 cm2 (p=0.17) in males and 16 ± 44 cm2 (p<0.01) and 4 ± 14 cm2 (p=0.056) in females, respectively. Waist circumference decreased significantly with mean differences of 3.9 ± 4.9 cm and 2.8 ± 4.4 cm in males and females, respectively (p<0.01). VAT/TAT withnissed a slight increase in males and reduction in females (p>0.05). In multivariate analysis, no significant associations were shown with mortality and progression rates.

Conclusion

This study provides data on the evolution of adipose tissues parameters in the peri-transplantation phase. TAT, VAT and WC decrease 3 months post transplantation. Future studies should evaluate the associations of these parameters with major outcomes on larger sample sizes.

Session topic: 22. Stem cell transplantation - Clinical

Keyword(s): Stem cell transplant, lymphoma

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