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SLEEP DISORDERED BREATHING IN CHILDREN AND ADOLESCENT WITH SICKLE CELL DISEASE: IMPACT ON EXECUTIVE FUNCTION AND PROCESSING SPEED INDEX
Author(s):
Melanie Koelbel
,
Melanie Koelbel
Affiliations:
UCL Great Ormond Street Institute of Child Health https://www.ucl.ac.uk/ich,London,United Kingdom
Jamie Kawadler
,
Jamie Kawadler
Affiliations:
Developmental Imaging & Biophysics,UCL Great Ormond Street Institute of Child Health https://www.ucl.ac.uk/ich,London,United Kingdom
Hanne Stotesbury
,
Hanne Stotesbury
Affiliations:
Developmental Imaging & Biophysics,UCL Great Ormond Street Institute of Child Health https://www.ucl.ac.uk/ich,London,United Kingdom
Philippa Balfour
,
Philippa Balfour
Affiliations:
Developmental Imaging & Biophysics,UCL Great Ormond Street Institute of Child Health https://www.ucl.ac.uk/ich,London,United Kingdom
Fenella Kirkham
Fenella Kirkham
Affiliations:
UCL Great Ormond Street Institute of Child Health https://www.ucl.ac.uk/ich,London,United Kingdom
(Abstract release date: 05/18/17) EHA Library. Koelbel M. 05/18/17; 182854; PB2141
Melanie Koelbel
Melanie Koelbel
Contributions
PDF Abstract
Abstract

Abstract: PB2141

Type: Publication Only

Background

Studies in non-syndromic children have shown that sleep-disordered breathing (SDB) increases the risk of neuropsychological deficits and neuronal brain injury. Few authors have investigated the role in cognitive deficits of SDB and the associated hypoxia in children with sickle cell disease (SCD). Snoring and SDB is very common in children with SCD and may affect cognitive function in very young children. Previous data suggested that executive function was worse in older children with SCD and low mean overnight oxygen saturation.

Aims
We aim to investigate if SDB could be a potential factor contributing to developmental problems in cognition in children and adolescent with SCD.

Methods
We have followed up children and adolescents in the Sleep Asthma cohort who underwent Polysomnography at two different time points (1) 2006-2009 and (2) 2011-2014 and compared the sleep data with subsequent neuropsychological assessment.

Results
Worse performance was found for processing speed: PSI (p< 0.01) and general intelligence (p<0.05) compared to control siblings. SDB, measured as apnea and hypoxia index (i.e. AHI >3%: Apnoeas and hypopnoeas with more than ≥ 3% desaturation), was found to impact executive function, as measured with the Tower test, (p<0.05) and PSI (p<0.05). Mean oxygen saturation during total sleep time was significantly associated with lower PSI (p<0.05). Additionally, participants who showed a worsening of their SDB symptoms in their second sleep study had lower cognitive scores (i.e., executive function, p<0.05 and PSI, p<0.05).

Conclusion

SDB symptoms seem to worsen into adolescence and therefore, might have a neurodevelopmental impact if left untreated; appropriate intervention might improve cognition and quality of life.

Session topic: 25. Sickle cell disease

Keyword(s): Children, Treatment, Sickle cell patient, Development

Abstract: PB2141

Type: Publication Only

Background

Studies in non-syndromic children have shown that sleep-disordered breathing (SDB) increases the risk of neuropsychological deficits and neuronal brain injury. Few authors have investigated the role in cognitive deficits of SDB and the associated hypoxia in children with sickle cell disease (SCD). Snoring and SDB is very common in children with SCD and may affect cognitive function in very young children. Previous data suggested that executive function was worse in older children with SCD and low mean overnight oxygen saturation.

Aims
We aim to investigate if SDB could be a potential factor contributing to developmental problems in cognition in children and adolescent with SCD.

Methods
We have followed up children and adolescents in the Sleep Asthma cohort who underwent Polysomnography at two different time points (1) 2006-2009 and (2) 2011-2014 and compared the sleep data with subsequent neuropsychological assessment.

Results
Worse performance was found for processing speed: PSI (p< 0.01) and general intelligence (p<0.05) compared to control siblings. SDB, measured as apnea and hypoxia index (i.e. AHI >3%: Apnoeas and hypopnoeas with more than ≥ 3% desaturation), was found to impact executive function, as measured with the Tower test, (p<0.05) and PSI (p<0.05). Mean oxygen saturation during total sleep time was significantly associated with lower PSI (p<0.05). Additionally, participants who showed a worsening of their SDB symptoms in their second sleep study had lower cognitive scores (i.e., executive function, p<0.05 and PSI, p<0.05).

Conclusion

SDB symptoms seem to worsen into adolescence and therefore, might have a neurodevelopmental impact if left untreated; appropriate intervention might improve cognition and quality of life.

Session topic: 25. Sickle cell disease

Keyword(s): Children, Treatment, Sickle cell patient, Development

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