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RISK OF LUPUS AFTER PRIMARY IMMUNE THROMBOCYTOPENIC PURPURA: A 14 YEAR SINGLE CENTER EXPERIENCE
Author(s):
Mahmoud Ayesh (Haj Yousef)
,
Mahmoud Ayesh (Haj Yousef)
Affiliations:
Medicine,Jordan University of Science and Technology,Irbid,Jordan
Khaldoon Alawneh
,
Khaldoon Alawneh
Affiliations:
Medicine,Jordan University of Science and Technology,Irbid,Jordan
Yousef Khader
,
Yousef Khader
Affiliations:
Public Health,Jordan University of Science and Technology,Irbid,Jordan
Fatima Malkawi
Fatima Malkawi
Affiliations:
Department of Laboratory, Kng Abdullah University Hospital,Irbid,Jordan
(Abstract release date: 05/18/17) EHA Library. Ayesh (Haj Yousef) M. 05/18/17; 182834; PB2121
Assoc. Prof. Mahmoud Ayesh (Haj Yousef)
Assoc. Prof. Mahmoud Ayesh (Haj Yousef)
Contributions
PDF Abstract
Abstract

Abstract: PB2121

Type: Publication Only

Background

Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated platelet destruction and suppressed platelet production. ITP may occur concurrently or precede the occurrence of SLE, which would have great diagnostic significance. ITP may also be the first early sign of the disease. Few studies have addressed the risk of systemic lupus erythematosus (SLE) after ITP.

Aims
To estimate the risk of SLE after ITP in adult Jordanian patients

Methods

All patients diagnosed with ITP and with a platelet count ˂100×109/L, between September 2002 and January 2017 were included in the study. Patients were retrospectively reviewed for diagnosis of SLE, and inclusion criteria included only those patients who had initial ANA screen at the time of the first presentation of ITP .All patents with the diagnosis of SLE at the time and before the presentation of primary ITP were excluded from the study.

Results
This study included a total of 58 patients (43 females and 15 males) who were followed up for a period of 14 years. Their age at the baseline ranged from 16 to 65 years with a mean (SD) of 31.2 (13.3). ANA was positive in 11 (19.0%) patients. Over the period of follow up, 9 (15.5%) patients developed lupus. The incidence was 13.3% among males and 16.3% among females, with no significant difference (p-value = 0.786). There was significant association between ANA and lupus in both genders. Only one patient with negative ANA and 81.8% of patients with positive ANA developed lupus (P<0.005.

Conclusion

SLE developed in patients with primary ITP in with initial positive ANA titer at presentation. The results suggest that patients with initial positive ANA are at risk for development SLE. Thus, follow up after primary ITP diagnosis with positive ANA titer is of great importance as the risk of SLE is significant

Session topic: 32. Platelets disorders

Keyword(s): Lupus, Idiopathic thombocytopenic purpura (ITP)

Abstract: PB2121

Type: Publication Only

Background

Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated platelet destruction and suppressed platelet production. ITP may occur concurrently or precede the occurrence of SLE, which would have great diagnostic significance. ITP may also be the first early sign of the disease. Few studies have addressed the risk of systemic lupus erythematosus (SLE) after ITP.

Aims
To estimate the risk of SLE after ITP in adult Jordanian patients

Methods

All patients diagnosed with ITP and with a platelet count ˂100×109/L, between September 2002 and January 2017 were included in the study. Patients were retrospectively reviewed for diagnosis of SLE, and inclusion criteria included only those patients who had initial ANA screen at the time of the first presentation of ITP .All patents with the diagnosis of SLE at the time and before the presentation of primary ITP were excluded from the study.

Results
This study included a total of 58 patients (43 females and 15 males) who were followed up for a period of 14 years. Their age at the baseline ranged from 16 to 65 years with a mean (SD) of 31.2 (13.3). ANA was positive in 11 (19.0%) patients. Over the period of follow up, 9 (15.5%) patients developed lupus. The incidence was 13.3% among males and 16.3% among females, with no significant difference (p-value = 0.786). There was significant association between ANA and lupus in both genders. Only one patient with negative ANA and 81.8% of patients with positive ANA developed lupus (P<0.005.

Conclusion

SLE developed in patients with primary ITP in with initial positive ANA titer at presentation. The results suggest that patients with initial positive ANA are at risk for development SLE. Thus, follow up after primary ITP diagnosis with positive ANA titer is of great importance as the risk of SLE is significant

Session topic: 32. Platelets disorders

Keyword(s): Lupus, Idiopathic thombocytopenic purpura (ITP)

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