Contributions
Abstract: PB2120
Type: Publication Only
Background
Aims
We wanted to investigate the impact of gestational age by determining variations in platelet volume parametres according to gestational weeks.
Methods
Medical records were prospectively reviewed in preterm infants admitted to Firat University Hospital from January 2001 to December 2007. Study group consisted of only one-hour-old newborns delivered in the clinics of Department of Gynecology, and Obstetrics of our hospital. The exclusion criteria included those with maternal history of antepartum haemorrhage, chorioamnionitis, fever, sepsis, preeclampsia and hypertension; and perinatal history of twin-to-twin transfusion syndrome, feto-maternal transfusion, injury and infection. A hundred and ninety-three newborns with apparent health problems were excluded from our study. Study group comprised 398 preterm infants born between 26-37 gestational weeks, and 63 healthy term (38 gestational weeks) infants. Blood samples from all cases were obtained within the first hours after birth. Blood samples were placed into tubes with EDTA, and analyzed in ADVIA 120® (Japan) hematology analyzer using suitable kits. Data were expressed as mean ± standard deviation. Platelet counts, and volume were indicated for each gestational week, and groups of 24-31, 32-36, 37, and 38 weeks. One-way analysis of variance (ANOVA) was used for statistical analysis, and p<0.05 was accepted as the level of statistical significance.We established the reference ranges of platelet and platelet index in Turkish preterm and term infants. Platelet counts, and platelet volumes continually change as gestational age increases. Increases in platelet counts, and PCT, while decreases in MPV and PDW were detected. The gestational age-related changes in PLT patterns may reflect maturation of platelet regulation.
Results
Platelet counts increased beginning from the 26th up to 28th weeks. They did not change between 29th and 33rd weeks, while their levels rised again conspicuosly between 34th and 37th weeks. At 38th week a dramatic increase occurred at 38th week. MPV, and PDW values slightly decreased, while PCT values increased dependent on the gestational age. When we classified newborns in groups of 24th-31th, 32th-36th, and 37th, and 38th weeks, prominent, and statistically significant variations were observed between groups (Table 1).
Conclusion
We established the reference ranges of platelet and platelet index in Turkish preterm and term infants. Platelet counts, and platelet volumes continually change as gestational age increases. Increases in platelet counts, and PCT, while decreases in MPV and PDW were detected. The gestational age-related changes in PLT patterns may reflect maturation of platelet regulation.
Session topic: 32. Platelets disorders
Keyword(s): Platelet count
Abstract: PB2120
Type: Publication Only
Background
Aims
We wanted to investigate the impact of gestational age by determining variations in platelet volume parametres according to gestational weeks.
Methods
Medical records were prospectively reviewed in preterm infants admitted to Firat University Hospital from January 2001 to December 2007. Study group consisted of only one-hour-old newborns delivered in the clinics of Department of Gynecology, and Obstetrics of our hospital. The exclusion criteria included those with maternal history of antepartum haemorrhage, chorioamnionitis, fever, sepsis, preeclampsia and hypertension; and perinatal history of twin-to-twin transfusion syndrome, feto-maternal transfusion, injury and infection. A hundred and ninety-three newborns with apparent health problems were excluded from our study. Study group comprised 398 preterm infants born between 26-37 gestational weeks, and 63 healthy term (38 gestational weeks) infants. Blood samples from all cases were obtained within the first hours after birth. Blood samples were placed into tubes with EDTA, and analyzed in ADVIA 120® (Japan) hematology analyzer using suitable kits. Data were expressed as mean ± standard deviation. Platelet counts, and volume were indicated for each gestational week, and groups of 24-31, 32-36, 37, and 38 weeks. One-way analysis of variance (ANOVA) was used for statistical analysis, and p<0.05 was accepted as the level of statistical significance.We established the reference ranges of platelet and platelet index in Turkish preterm and term infants. Platelet counts, and platelet volumes continually change as gestational age increases. Increases in platelet counts, and PCT, while decreases in MPV and PDW were detected. The gestational age-related changes in PLT patterns may reflect maturation of platelet regulation.
Results
Platelet counts increased beginning from the 26th up to 28th weeks. They did not change between 29th and 33rd weeks, while their levels rised again conspicuosly between 34th and 37th weeks. At 38th week a dramatic increase occurred at 38th week. MPV, and PDW values slightly decreased, while PCT values increased dependent on the gestational age. When we classified newborns in groups of 24th-31th, 32th-36th, and 37th, and 38th weeks, prominent, and statistically significant variations were observed between groups (Table 1).
Conclusion
We established the reference ranges of platelet and platelet index in Turkish preterm and term infants. Platelet counts, and platelet volumes continually change as gestational age increases. Increases in platelet counts, and PCT, while decreases in MPV and PDW were detected. The gestational age-related changes in PLT patterns may reflect maturation of platelet regulation.
Session topic: 32. Platelets disorders
Keyword(s): Platelet count