VITAMIN D RECEPTOR GENE POLYMORPHISMS IN ADULT PRIMARY IMMUNE THROMBOCYTOPENIA
(Abstract release date: 05/18/17)
EHA Library. Sakr M. 05/18/17; 182817; PB2103
Mohamed Sakr
Contributions
Contributions
Abstract
Abstract: PB2103
Type: Publication Only
Background
Recently, several studies have demonstrated the role of vitamin D receptor (VDR) polymorphisms in the development of autoimmune diseases. Vitamin D affect both innate and adaptive immune responses that have been blamed in immune thrombocytopenia (ITP) pathogenesis.
Aims
The aim of this study is to assess the association of vitamin D receptor gene polymorphism BsmI in cases of adult primary immune thrombocytopenia.
Methods
Vitamin D receptor polymorphism BsmI (rs1544410) was detected by Polymerase Chain Reaction followed by Restriction Fragment Length Polymorphism (PCR–RFLP). Deoxyribonucleic acid (DNA) samples were extracted from peripheral blood of 40 ITP patients and 60 geographically and ethnically matched healthy controls.
Results
Statistically significant difference was found in the BsmI polymorphism between ITP patients and controls (χ2 = 8.77, P value=0.01). The BsmI polymorphism B allele was higher in ITP group than that in controls but in statistically insignificant difference (χ2 = 2.125, P = 0.145). bb genotype played a protective role in ITP incidence.
Conclusion
This is the first published report on VDR gene polymorphisms in adult primary ITP patients. The BsmI genotype was associated with increased risk for ITP incidence with no obvious effect on bleeding severity, platelet count nor site of bleeding.
Session topic: 32. Platelets disorders
Keyword(s): Polymorphism, Immune thrombocytopenia (ITP)
Abstract: PB2103
Type: Publication Only
Background
Recently, several studies have demonstrated the role of vitamin D receptor (VDR) polymorphisms in the development of autoimmune diseases. Vitamin D affect both innate and adaptive immune responses that have been blamed in immune thrombocytopenia (ITP) pathogenesis.
Aims
The aim of this study is to assess the association of vitamin D receptor gene polymorphism BsmI in cases of adult primary immune thrombocytopenia.
Methods
Vitamin D receptor polymorphism BsmI (rs1544410) was detected by Polymerase Chain Reaction followed by Restriction Fragment Length Polymorphism (PCR–RFLP). Deoxyribonucleic acid (DNA) samples were extracted from peripheral blood of 40 ITP patients and 60 geographically and ethnically matched healthy controls.
Results
Statistically significant difference was found in the BsmI polymorphism between ITP patients and controls (χ2 = 8.77, P value=0.01). The BsmI polymorphism B allele was higher in ITP group than that in controls but in statistically insignificant difference (χ2 = 2.125, P = 0.145). bb genotype played a protective role in ITP incidence.
Conclusion
This is the first published report on VDR gene polymorphisms in adult primary ITP patients. The BsmI genotype was associated with increased risk for ITP incidence with no obvious effect on bleeding severity, platelet count nor site of bleeding.
Session topic: 32. Platelets disorders
Keyword(s): Polymorphism, Immune thrombocytopenia (ITP)
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