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THE ROLE OF MEAN PLATELET VOLUME IN NEONATAL SEPSIS: A RETROSPECTIVE CASE CONTROL STUDY IN A LEVEL III NEONATAL INTENSIVE CARE UNIT.
Author(s):
Anand Srinivasan
,
Anand Srinivasan
Affiliations:
Pediatrics,Harlem Hospital Center,New York,United States
Xavier Ameer
,
Xavier Ameer
Affiliations:
Pediatrics,Harlem Hospital Center,New York,United States
Mary Marron-Corwin
Mary Marron-Corwin
Affiliations:
Pediatrics,Harlem Hospital Center,New York,United States
(Abstract release date: 05/18/17) EHA Library. Srinivasan A. 05/18/17; 182814; PB2100
Anand Srinivasan
Anand Srinivasan
Contributions
PDF Abstract
Abstract

Abstract: PB2100

Type: Publication Only

Background
Sepsis is a relatively common diagnosis in the neonatal period. Apart from blood cultures which are the gold standard, C-reactive protein (CRP), total white blood cell count (WBC) and the ratio of immature to mature neutrophils (I:T) are considered to be useful markers of sepsis in the neonatal period. There are a few studies that show that mean platelet volume (MPV) is elevated in infectious disease processes.

Aims
The aim of this study was to investigate whether mean platelet volume is increased in neonates with sepsis.

Methods
Only term neonates were included in the study. Exclusion criteria included: (a) Any neonate born with a genetic defect, (b) Any neonate with suspected immunodeficiency, (c) Any neonate requiring surgery in the post-natal period, (d) Neonates admitted to NICU for hyperbilirubinemia, (e) Neonates requiring extensive resuscitation at birth resulting in documented Hypoxic Ischemic Encephalopathy or requiring transfer to a Regional Perinatal Center.

Medical records were reviewed from March 2015 to June 2016 and a total of 114 eligible neonates were included in the study and they were divided into 2 groups: 39 neonates with clinical sepsis (as defined by either culture positivity and/or clinical features plus treatment with antibiotics exceeding 48 hours) and 75 healthy controls (as defined by neonates in whom antibiotics were never started or discontinued when cultures were negative for 48 hours and the absence of clinical features of sepsis). Total white blood cell count, C-reactive protein, immature to total neutrophil count and mean platelet volume drawn on two occasions (first within 24 hours and the second between 24 to 48 hours after delivery) were compared between the two groups.

Results
There was no statistically significant difference in the mean platelet volume between the study group and the control group (p value 0.9 in the first 24 hours and p value of 1 in the 24-48 hour sample). There was however, a statistically significant difference between immature to total neutrophil count and C-reactive protein on both samples (p value <0.0001).

Conclusion

In our study there was no statistically significant difference in the mean platelet volume values between neonates with sepsis and healthy controls. C-reactive protein and immature to total neutrophil count continue to be reliable markers of neonatal sepsis.

Session topic: 32. Platelets disorders

Abstract: PB2100

Type: Publication Only

Background
Sepsis is a relatively common diagnosis in the neonatal period. Apart from blood cultures which are the gold standard, C-reactive protein (CRP), total white blood cell count (WBC) and the ratio of immature to mature neutrophils (I:T) are considered to be useful markers of sepsis in the neonatal period. There are a few studies that show that mean platelet volume (MPV) is elevated in infectious disease processes.

Aims
The aim of this study was to investigate whether mean platelet volume is increased in neonates with sepsis.

Methods
Only term neonates were included in the study. Exclusion criteria included: (a) Any neonate born with a genetic defect, (b) Any neonate with suspected immunodeficiency, (c) Any neonate requiring surgery in the post-natal period, (d) Neonates admitted to NICU for hyperbilirubinemia, (e) Neonates requiring extensive resuscitation at birth resulting in documented Hypoxic Ischemic Encephalopathy or requiring transfer to a Regional Perinatal Center.

Medical records were reviewed from March 2015 to June 2016 and a total of 114 eligible neonates were included in the study and they were divided into 2 groups: 39 neonates with clinical sepsis (as defined by either culture positivity and/or clinical features plus treatment with antibiotics exceeding 48 hours) and 75 healthy controls (as defined by neonates in whom antibiotics were never started or discontinued when cultures were negative for 48 hours and the absence of clinical features of sepsis). Total white blood cell count, C-reactive protein, immature to total neutrophil count and mean platelet volume drawn on two occasions (first within 24 hours and the second between 24 to 48 hours after delivery) were compared between the two groups.

Results
There was no statistically significant difference in the mean platelet volume between the study group and the control group (p value 0.9 in the first 24 hours and p value of 1 in the 24-48 hour sample). There was however, a statistically significant difference between immature to total neutrophil count and C-reactive protein on both samples (p value <0.0001).

Conclusion

In our study there was no statistically significant difference in the mean platelet volume values between neonates with sepsis and healthy controls. C-reactive protein and immature to total neutrophil count continue to be reliable markers of neonatal sepsis.

Session topic: 32. Platelets disorders

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