Contributions
Abstract: PB2098
Type: Publication Only
Background
Primary immune thrombocytopenia (ITP) is an immune disorder with varied course. According the duration of the disease, it is distinguished in newly diagnosed (<3 months), persistent (3-12 months) and chronic (> 12 months). International studies have highlighted prognostic factors for each form of ITP in children, but similar studies have yet to be been performed in Greece.
Aims
The evaluation of clinical and laboratory parameters and the identification of prognostic markers for the three forms of the disease in children with ITP from an academic reference center in Greece.
Methods
Results
39 children had newly diagnosed, 4 had persistent and 14 had chronic disease. Due to the small number of children with persistent form they were incorporated in the group of children with newly diagnosed ITP. In chronic ITP children are more likely be above 10 years of age (p=0.015)and to have gradual initiation of the disease (p=0.001) compared with newly diagnosed/persistent group (57% vs 21% and 79% vs 9%, respectively). Recent history of infection was found mainly in newly diagnosed/persistent group (79% vs 21%, p=0.013). Platelet count below 10 x 109/L at diagnosis was found more frequently in newly diagnosed/persistent group (79% vs 36%, p=0.01). Similar, but not statistically significant difference, was found with mucosal bleedings (70% vs 50%, p=0.81). Children with newly diagnosed/persistent disease had less frequently impaired immunological markers (12% vs 65%, p <0.003) and received more frequent intravenous gamma globulin and/or corticosteroids (p>0.05). None of the children exhibited severe spontaneous bleeding.
Conclusion
Even though ITP in children is usually a self-limited disease, with rare serious bleeding complications, the newly diagnosed/persistent and the chronic form of the disease are characterized by different predictive parameters that can be used in clinical practice.
Session topic: 32. Platelets disorders
Keyword(s): Prognostic factor, Pediatric, Immune thrombocytopenia (ITP)
Abstract: PB2098
Type: Publication Only
Background
Primary immune thrombocytopenia (ITP) is an immune disorder with varied course. According the duration of the disease, it is distinguished in newly diagnosed (<3 months), persistent (3-12 months) and chronic (> 12 months). International studies have highlighted prognostic factors for each form of ITP in children, but similar studies have yet to be been performed in Greece.
Aims
The evaluation of clinical and laboratory parameters and the identification of prognostic markers for the three forms of the disease in children with ITP from an academic reference center in Greece.
Methods
Results
39 children had newly diagnosed, 4 had persistent and 14 had chronic disease. Due to the small number of children with persistent form they were incorporated in the group of children with newly diagnosed ITP. In chronic ITP children are more likely be above 10 years of age (p=0.015)and to have gradual initiation of the disease (p=0.001) compared with newly diagnosed/persistent group (57% vs 21% and 79% vs 9%, respectively). Recent history of infection was found mainly in newly diagnosed/persistent group (79% vs 21%, p=0.013). Platelet count below 10 x 109/L at diagnosis was found more frequently in newly diagnosed/persistent group (79% vs 36%, p=0.01). Similar, but not statistically significant difference, was found with mucosal bleedings (70% vs 50%, p=0.81). Children with newly diagnosed/persistent disease had less frequently impaired immunological markers (12% vs 65%, p <0.003) and received more frequent intravenous gamma globulin and/or corticosteroids (p>0.05). None of the children exhibited severe spontaneous bleeding.
Conclusion
Even though ITP in children is usually a self-limited disease, with rare serious bleeding complications, the newly diagnosed/persistent and the chronic form of the disease are characterized by different predictive parameters that can be used in clinical practice.
Session topic: 32. Platelets disorders
Keyword(s): Prognostic factor, Pediatric, Immune thrombocytopenia (ITP)