CAUSES OF IRON DEFICIENCY ANEMIA IN THE HEMATOLOGY CLINIC - SINGLE CENTER EXPERIENCE
(Abstract release date: 05/18/17)
EHA Library. Ionita M. 05/18/17; 182806; PB2092
Mihai Ionita
Contributions
Contributions
Abstract
Abstract: PB2092
Type: Publication Only
Background
Iron deficiency anemia (IDA) is the common nutritional deficiency worldwide. The studies concerning various causes of IDA in adult men are rare, although it is assumed that chronic gastrointestinal blood accounts for the majority.
Aims
of the study is to evaluate retrospectively adult men with IDA that were hospitalized in our Hematology Clinic.
Methods
Two hundred fifteen male with IDA were enlisted at this study from January 2005 to december 2015. Anemia was defined as Hg < 13g/dL using the WHO criteria. IDA was considered present if serum ferritin was 15 ng/mL combined with serum iron concentration < 30ug/dL with a transferrin saturation of < 10%. Complete physical examination, the history of the disease and fecal occult blood test (FOBT) of three spontaneously passed stools was done in all patients. All patients had complete blood count, serum and total iron binding capacity, and a serum ferritin level. Most patients underwent esophagogastroduodenoscopy (EGD). Colonoscopy was performed if lesion that caused IDA was not found, and/or FOBT was positive.The abdominal CT scan were performed according to clinician's recomandation together with other tests related with blood lost.
Results
The median age was 62 ( range 32 to 86 ) years old. 168 of 215 ( 78.13% ) men with IDA had symptoms such as fatigue, dizzines, or digestive complaints. The history of prior gastrectomy, hemorrhoid, that probably had caused IDA were reported in 32 (14,88%), 43 (20.0%), patients, respectively. FOBT was positive in only 65 (30.23%) subjects. 170 (79.06%) patients underwent EGD. The most common findings from EGD were gastritis (48 patients) and peptic ulcer (39 patients). Seventy eight (36.27%) patients were found to have upper gastrointestinal disorders ( 20 patients with erosive gastritis, 19 gastric ulcer, 16 duodenal ulcer, 23 gastric cancer. Eighty-nine (41.39%) patients underwent colonoscopy. That showed 44 clinically important lesions that probably caused IDA ; colon cancer in 17 (7.90%) patients, colon polyp in 10 (4.65%) patients and hemorrhoid in 17 (7,90 %) patients. Concerning malignant lesions which are responsible for IDA, the malignant lesions were found more frequent in patients older than 50 years accounting for 20.45 % (27/132 patients) and patients younger than 50 years 17.80 % (13/73 patients).
Conclusion
This study demonstrated that gastrointestinal blood loss is the main cause of IDA in adult men, and that there is a high rate of malignancy in men older than 50 years.
Session topic: 31. Other Non-malignant hematopoietic disorders
Keyword(s): Iron deficiency anemia, Bleeding
Abstract: PB2092
Type: Publication Only
Background
Iron deficiency anemia (IDA) is the common nutritional deficiency worldwide. The studies concerning various causes of IDA in adult men are rare, although it is assumed that chronic gastrointestinal blood accounts for the majority.
Aims
of the study is to evaluate retrospectively adult men with IDA that were hospitalized in our Hematology Clinic.
Methods
Two hundred fifteen male with IDA were enlisted at this study from January 2005 to december 2015. Anemia was defined as Hg < 13g/dL using the WHO criteria. IDA was considered present if serum ferritin was 15 ng/mL combined with serum iron concentration < 30ug/dL with a transferrin saturation of < 10%. Complete physical examination, the history of the disease and fecal occult blood test (FOBT) of three spontaneously passed stools was done in all patients. All patients had complete blood count, serum and total iron binding capacity, and a serum ferritin level. Most patients underwent esophagogastroduodenoscopy (EGD). Colonoscopy was performed if lesion that caused IDA was not found, and/or FOBT was positive.The abdominal CT scan were performed according to clinician's recomandation together with other tests related with blood lost.
Results
The median age was 62 ( range 32 to 86 ) years old. 168 of 215 ( 78.13% ) men with IDA had symptoms such as fatigue, dizzines, or digestive complaints. The history of prior gastrectomy, hemorrhoid, that probably had caused IDA were reported in 32 (14,88%), 43 (20.0%), patients, respectively. FOBT was positive in only 65 (30.23%) subjects. 170 (79.06%) patients underwent EGD. The most common findings from EGD were gastritis (48 patients) and peptic ulcer (39 patients). Seventy eight (36.27%) patients were found to have upper gastrointestinal disorders ( 20 patients with erosive gastritis, 19 gastric ulcer, 16 duodenal ulcer, 23 gastric cancer. Eighty-nine (41.39%) patients underwent colonoscopy. That showed 44 clinically important lesions that probably caused IDA ; colon cancer in 17 (7.90%) patients, colon polyp in 10 (4.65%) patients and hemorrhoid in 17 (7,90 %) patients. Concerning malignant lesions which are responsible for IDA, the malignant lesions were found more frequent in patients older than 50 years accounting for 20.45 % (27/132 patients) and patients younger than 50 years 17.80 % (13/73 patients).
Conclusion
This study demonstrated that gastrointestinal blood loss is the main cause of IDA in adult men, and that there is a high rate of malignancy in men older than 50 years.
Session topic: 31. Other Non-malignant hematopoietic disorders
Keyword(s): Iron deficiency anemia, Bleeding
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