EHA Library - The official digital education library of European Hematology Association (EHA)

COMPARISONS OF PATIENT MANAGEMENT IN MYELOPROLIFERATIVE NEOPLASM PATIENTS IN THE UK VS REST OF WORLD: ANALYSIS FROM THE INTERNATIONAL LANDMARK SURVEY
Author(s): ,
Claire Harrison
Affiliations:
Guy's and St Thomas' NHS Foundation Trust,Guy's Hospital,London,United Kingdom
,
Zack Pemberton-Whiteley
Affiliations:
Head of Campaigns and Advocacy,Leukaemia CARE,Worcester,United Kingdom
,
Adam Mead
Affiliations:
Weatherall Institute of Molecular Medicine,University of Oxford,Oxford,United Kingdom
,
Sahra Ali
Affiliations:
Queens Centre,Castle Hill Hospital,Cottingham,United Kingdom
,
Jonathan Mathias
Affiliations:
MPN Voice,London,United Kingdom
,
Caroline Thomas
Affiliations:
MPN Voice,London,United Kingdom
,
Maz Campbell-Drew
Affiliations:
MPN Voice,London,United Kingdom
,
Gavin Taylor-Stokes
Affiliations:
Adelphi Real World,Bollington,United Kingdom
,
John Waller
Affiliations:
Adelphi Real World,Bollington,United Kingdom
,
Aurelie Duces
Affiliations:
Haematology Franchise,Novartis Pharmaceuticals,Camberley,United Kingdom
Barbara Taylor
Affiliations:
Haematology Franchise,Novartis Pharmaceuticals,Camberley,United Kingdom
(Abstract release date: 05/18/17) EHA Library. Harrison C. 05/18/17; 182759; PB2045
Prof. Dr. Claire Harrison
Prof. Dr. Claire Harrison
Contributions
Abstract

Abstract: PB2045

Type: Publication Only

Background
Patient (Pts) with myeloproliferative neoplasms (MPNs), including myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET), experience a substantial disease burden. The international MPN LANDMARK survey evaluated the patient-reported impact of MPNs in pts across 6 countries and identified current treatment strategies in these pts.

Aims
To analyze differences in treatment strategies used by physicians and pts to manage their MPN between the UK and the Rest of Surveyed World (ROSW).

Methods
A cross-sectional survey was conducted in Australia, Canada, Germany, Italy, Japan, and the UK. The Internet-based survey was administered separately to MPN patients and treating physicians (the two samples were not linked). Observed differences between the UK and ROSW are described in terms of treatment patterns and patient physician communication.

Results

A total of 699 pts (UK, n=286; ROSW, n=413) and 219 physicians (UK, n=31; ROSW, n=188) completed the survey. UK physicians were more likely to start treatment rather than delay at diagnosis of PV or ET. A greater proportion of ROSW physicians reported they would observe >25% of patients at diagnosis (UK - 54% MF, 30% PV, 37% ET; ROSW – 51% MF, 48% PV, 50% ET). No difference was observed in the most commonly received treatments for each disease, but a greater proportion of UK patients reported receiving treatments than ROSW. This difference was greater in PV and ET than MF. For MF the most commonly received treatments were ruxolitinib (UK 55%, ROSW 50%), aspirin (UK 53%, ROSW 37%), hydroxyurea (HU) (UK 31%, ROSW 28%) and transfusion (UK 27%, ROSW 23%), for PV they were aspirin (UK 83%, ROSW 58%), phlebotomy (UK 76%, ROSW 67%) and HU (UK 63%, ROSW 36%) and for ET they were aspirin (UK 94%, ROSW 52%), HU (UK 62%, 30% ROSW) and anagrelide (UK 14%, ROSW 18%). Physician reported data on treatments prescribed demonstrated a similar pattern as a greater proportion of UK physicians reported using treatments than ROSW.
UK physicians reported that their patients were more likely to ‘often’ disagree with their primary treatment recommendation than ROSW (16% vs 7%) but despite this UK patients were more likely to be ‘completely’ satisfied with their physicians understanding and support of their treatment goals (UK, 51%; ROSW 35%). Patients rated who they thought should be the main decision maker on a scale of 1 (the patient) to 10 (physician). UK patients were slightly more inclined to want to be involved in treatment decisions (mean: UK, 6.25; ROSW, 7.01). UK physicians supported this as more ‘agreed strongly’ with the statement ‘I involve my MPN patients in treatment decisions’’ (UK, 39%; ROSW 28%).

Conclusion
In comparison with ROSW: UK physicians were more likely to prescribe drug treatments for ET/PV. Interestingly, UK patients desired to be more involved in treatment decisions, and this was reflected in the physician’s perspective to involve their patient in treatment decisions more. UK patients were also more likely to disagree with their physician on primary treatment recommendations. However, this had no impact on satisfaction suggesting that UK patients welcome an open discussion on treatment options with their physician. These data highlight the importance of maximizing patient physician communication in order to improve patient satisfaction with treatment in the UK.

Session topic: 16. Myeloproliferative neoplasms - Clinical

Keyword(s): Polycythemia vera, Myelofibrosis, Essential Thrombocytemia

Abstract: PB2045

Type: Publication Only

Background
Patient (Pts) with myeloproliferative neoplasms (MPNs), including myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET), experience a substantial disease burden. The international MPN LANDMARK survey evaluated the patient-reported impact of MPNs in pts across 6 countries and identified current treatment strategies in these pts.

Aims
To analyze differences in treatment strategies used by physicians and pts to manage their MPN between the UK and the Rest of Surveyed World (ROSW).

Methods
A cross-sectional survey was conducted in Australia, Canada, Germany, Italy, Japan, and the UK. The Internet-based survey was administered separately to MPN patients and treating physicians (the two samples were not linked). Observed differences between the UK and ROSW are described in terms of treatment patterns and patient physician communication.

Results

A total of 699 pts (UK, n=286; ROSW, n=413) and 219 physicians (UK, n=31; ROSW, n=188) completed the survey. UK physicians were more likely to start treatment rather than delay at diagnosis of PV or ET. A greater proportion of ROSW physicians reported they would observe >25% of patients at diagnosis (UK - 54% MF, 30% PV, 37% ET; ROSW – 51% MF, 48% PV, 50% ET). No difference was observed in the most commonly received treatments for each disease, but a greater proportion of UK patients reported receiving treatments than ROSW. This difference was greater in PV and ET than MF. For MF the most commonly received treatments were ruxolitinib (UK 55%, ROSW 50%), aspirin (UK 53%, ROSW 37%), hydroxyurea (HU) (UK 31%, ROSW 28%) and transfusion (UK 27%, ROSW 23%), for PV they were aspirin (UK 83%, ROSW 58%), phlebotomy (UK 76%, ROSW 67%) and HU (UK 63%, ROSW 36%) and for ET they were aspirin (UK 94%, ROSW 52%), HU (UK 62%, 30% ROSW) and anagrelide (UK 14%, ROSW 18%). Physician reported data on treatments prescribed demonstrated a similar pattern as a greater proportion of UK physicians reported using treatments than ROSW.
UK physicians reported that their patients were more likely to ‘often’ disagree with their primary treatment recommendation than ROSW (16% vs 7%) but despite this UK patients were more likely to be ‘completely’ satisfied with their physicians understanding and support of their treatment goals (UK, 51%; ROSW 35%). Patients rated who they thought should be the main decision maker on a scale of 1 (the patient) to 10 (physician). UK patients were slightly more inclined to want to be involved in treatment decisions (mean: UK, 6.25; ROSW, 7.01). UK physicians supported this as more ‘agreed strongly’ with the statement ‘I involve my MPN patients in treatment decisions’’ (UK, 39%; ROSW 28%).

Conclusion
In comparison with ROSW: UK physicians were more likely to prescribe drug treatments for ET/PV. Interestingly, UK patients desired to be more involved in treatment decisions, and this was reflected in the physician’s perspective to involve their patient in treatment decisions more. UK patients were also more likely to disagree with their physician on primary treatment recommendations. However, this had no impact on satisfaction suggesting that UK patients welcome an open discussion on treatment options with their physician. These data highlight the importance of maximizing patient physician communication in order to improve patient satisfaction with treatment in the UK.

Session topic: 16. Myeloproliferative neoplasms - Clinical

Keyword(s): Polycythemia vera, Myelofibrosis, Essential Thrombocytemia

By clicking “Accept Terms & all Cookies” or by continuing to browse, you agree to the storing of third-party cookies on your device to enhance your user experience and agree to the user terms and conditions of this learning management system (LMS).

Cookie Settings
Accept Terms & all Cookies