Contributions
Abstract: PB2018
Type: Publication Only
Background
The cast nephropathy with cylinders is the most frequent renal complication of the myeloma, which results from a catabolism of the light chains by the tubular cells and can lead a tubular chronic suffering showing itself by a syndrome of acquired Toni-Debré-Fanconi marked by a glycosuria, a phosphaturia, an aminoaciduria, a sometimes severe and sometimes revealing hypokalemia.
Aims
We reporting some observations informed by Multiple Myeloma complicated with a Fanconi syndrome.
Methods
From January 2000 till December 2010: 78 cases of Multiple Myeloma were brought together, whose circumstance of discovery 22 cases with renal failure, it’s was a evolutes complications in 12 cases; and in 10 cases it’s discovered at diagnosis. The renal achievement is dominated by Tubule disease in 11 cases, Randall syndrome 8 cases, and Nephrotic syndrome in 3 cases. The tubule disease of Fanconi is suspected at only 8 patients: in front of the presence of a renal glycosuria (without associated diabetes) and a frank proteinuria in the majority of the cases, with a hypophosphatemia and a fickle hypokalemia.
Results
The clinico-epidemiological and immuno-biological characters of these 8 patients are the following ones:
Conclusion
The Syndrome of Fanconi is a frequent and often formidable complication during Myeloma, observed to 30-40% of the patients in an autopsique series. It is necessary to think to it in front of any renal achievement in myeloma of kappa light chain with renal glycosuria, a generalized amino-aciduria and a hypophosphatemia resulting respectively from a defect of the transport of the glucose, from amino acids and from phosphates by the renal proximal tubule. To improve the osseous and renal appearances, it is necessary to realize a calcic supplementation, phosphorous and by the vitamin D active, as well as the correction of the acidose and a specific treatment reducing the excretion renal of the light chains.
Session topic: 14. Myeloma and other monoclonal gammopathies - Clinical
Keyword(s): Multiple Myeloma
Abstract: PB2018
Type: Publication Only
Background
The cast nephropathy with cylinders is the most frequent renal complication of the myeloma, which results from a catabolism of the light chains by the tubular cells and can lead a tubular chronic suffering showing itself by a syndrome of acquired Toni-Debré-Fanconi marked by a glycosuria, a phosphaturia, an aminoaciduria, a sometimes severe and sometimes revealing hypokalemia.
Aims
We reporting some observations informed by Multiple Myeloma complicated with a Fanconi syndrome.
Methods
From January 2000 till December 2010: 78 cases of Multiple Myeloma were brought together, whose circumstance of discovery 22 cases with renal failure, it’s was a evolutes complications in 12 cases; and in 10 cases it’s discovered at diagnosis. The renal achievement is dominated by Tubule disease in 11 cases, Randall syndrome 8 cases, and Nephrotic syndrome in 3 cases. The tubule disease of Fanconi is suspected at only 8 patients: in front of the presence of a renal glycosuria (without associated diabetes) and a frank proteinuria in the majority of the cases, with a hypophosphatemia and a fickle hypokalemia.
Results
The clinico-epidemiological and immuno-biological characters of these 8 patients are the following ones:
Conclusion
The Syndrome of Fanconi is a frequent and often formidable complication during Myeloma, observed to 30-40% of the patients in an autopsique series. It is necessary to think to it in front of any renal achievement in myeloma of kappa light chain with renal glycosuria, a generalized amino-aciduria and a hypophosphatemia resulting respectively from a defect of the transport of the glucose, from amino acids and from phosphates by the renal proximal tubule. To improve the osseous and renal appearances, it is necessary to realize a calcic supplementation, phosphorous and by the vitamin D active, as well as the correction of the acidose and a specific treatment reducing the excretion renal of the light chains.
Session topic: 14. Myeloma and other monoclonal gammopathies - Clinical
Keyword(s): Multiple Myeloma