Contributions
Abstract: PB2016
Type: Publication Only
Background
Sarawak, is the largest state of Malaysia situated on the island of Borneo. Sarawak General Hospital is the tertiary referral center of Sarawak (serving a population about 1 million people). It is 980 km away from its main hematology/transplant referral center in Kuala Lumpur, Malaysia, which is accessible only by airplane. Hence, treatment of patients with multiple myeloma in this part of the state is a big challenge due to its geographical constraint.
Aims
To identify demographics and clinical characteristics of patients with multiple myeloma; To establish treatment and outcome of patients with multiple myeloma.
Methods
This is a retrospective study examining basic characteristics and clinical outcomes of patients diagnosed with multiple myeloma between 2010 and 2016 in Sarawak General Hospital. Patients’ case notes were traced and the relevant information was entered into a pre-designed data collection form. Data was analysed and interpreted via IBM SPSS Statistics version 24.0.
Results
There were a total of 63 patients with the male to female ratio of 3:2. The median age for patient was 61 years old (range 31 to 86 years old). Majority of them are local natives of Iban or Bidayuh descendants (n=32, 50.8%) followed by Chinese (n=20, 31.7%) and Malays (n=11, 17.5%). Most common type of multiple myeloma is of IgG variant (n=27, 42.9%). The most common myeloma related organ or tissue impairment (ROTI) are anaemia (n=54, 85.7%) followed by bone lesion (n=48, 77.8%), renal impairment (n=27, 42.9%) and hypercalcaemia (n= 18, 28.6%). More than half presented late with Durie Salmon stage III disease (n=34, 54%). Majority of patients were treated with dexamethasone/thalidomide (n=25, 39.7%). Sixteen patients (25%) received bortezomib based treatment. Three patients (n=3, 4.8%) undergone bone marrow transplant.
Conclusion
Baseline characteristics of patients with multiple myeloma in Borneo Sarawak are similar to the rest of Asia. However, our median overall survival was comparatively lower to our counterparts. Limitation wise, due to logistic and economic reasons, we do not have good access to cytogenetic and genetic profiling that enables us to prognosticate patients accordingly.
Session topic: 14. Myeloma and other monoclonal gammopathies - Clinical
Keyword(s): Outcome, Myeloma
Abstract: PB2016
Type: Publication Only
Background
Sarawak, is the largest state of Malaysia situated on the island of Borneo. Sarawak General Hospital is the tertiary referral center of Sarawak (serving a population about 1 million people). It is 980 km away from its main hematology/transplant referral center in Kuala Lumpur, Malaysia, which is accessible only by airplane. Hence, treatment of patients with multiple myeloma in this part of the state is a big challenge due to its geographical constraint.
Aims
To identify demographics and clinical characteristics of patients with multiple myeloma; To establish treatment and outcome of patients with multiple myeloma.
Methods
This is a retrospective study examining basic characteristics and clinical outcomes of patients diagnosed with multiple myeloma between 2010 and 2016 in Sarawak General Hospital. Patients’ case notes were traced and the relevant information was entered into a pre-designed data collection form. Data was analysed and interpreted via IBM SPSS Statistics version 24.0.
Results
There were a total of 63 patients with the male to female ratio of 3:2. The median age for patient was 61 years old (range 31 to 86 years old). Majority of them are local natives of Iban or Bidayuh descendants (n=32, 50.8%) followed by Chinese (n=20, 31.7%) and Malays (n=11, 17.5%). Most common type of multiple myeloma is of IgG variant (n=27, 42.9%). The most common myeloma related organ or tissue impairment (ROTI) are anaemia (n=54, 85.7%) followed by bone lesion (n=48, 77.8%), renal impairment (n=27, 42.9%) and hypercalcaemia (n= 18, 28.6%). More than half presented late with Durie Salmon stage III disease (n=34, 54%). Majority of patients were treated with dexamethasone/thalidomide (n=25, 39.7%). Sixteen patients (25%) received bortezomib based treatment. Three patients (n=3, 4.8%) undergone bone marrow transplant.
Conclusion
Baseline characteristics of patients with multiple myeloma in Borneo Sarawak are similar to the rest of Asia. However, our median overall survival was comparatively lower to our counterparts. Limitation wise, due to logistic and economic reasons, we do not have good access to cytogenetic and genetic profiling that enables us to prognosticate patients accordingly.
Session topic: 14. Myeloma and other monoclonal gammopathies - Clinical
Keyword(s): Outcome, Myeloma