
Contributions
Abstract: PB1933
Type: Publication Only
Background
Aims
Methods
Results
We observed a decrease of apoptosis of MM plasma cells when are in co-culture with pathological MSCs at short-term (24h, 7AAD positive cells MM alone: 4.8%, MM in co-culture: 0.4%) and mid-term (72h, 7AAD positive cells MM alone: 16.4%, MM in co-culture: 10.7%) compared with MM plasma cells alone. However MM plasma cells not decreases the level of apoptosis at mid-term with healthy MSCs in co-cultures (72h, 7AAD positive cells MM alone: 16.4%, MM in co-culture: 18.0%). The molecular analysis showed a correlation between MSC lack of protection over MM plasma cells and the decrease in the levels of expression of VCAM-1 (CD106).
Conclusion
Session topic: 13. Myeloma and other monoclonal gammopathies - Biology
Keyword(s): Mesenchymal stem cell, VCAM-1, Myeloma
Abstract: PB1933
Type: Publication Only
Background
Aims
Methods
Results
We observed a decrease of apoptosis of MM plasma cells when are in co-culture with pathological MSCs at short-term (24h, 7AAD positive cells MM alone: 4.8%, MM in co-culture: 0.4%) and mid-term (72h, 7AAD positive cells MM alone: 16.4%, MM in co-culture: 10.7%) compared with MM plasma cells alone. However MM plasma cells not decreases the level of apoptosis at mid-term with healthy MSCs in co-cultures (72h, 7AAD positive cells MM alone: 16.4%, MM in co-culture: 18.0%). The molecular analysis showed a correlation between MSC lack of protection over MM plasma cells and the decrease in the levels of expression of VCAM-1 (CD106).
Conclusion
Session topic: 13. Myeloma and other monoclonal gammopathies - Biology
Keyword(s): Mesenchymal stem cell, VCAM-1, Myeloma