Contributions
Abstract: PB1909
Type: Publication Only
Background
soluble transferrin receptor (sTfR) is an early marker of tissue iron deficiency before onset of anaemia. sTfR is one of the noninvasive tools for early diagnosis of iron deficiency anaemia, which is one of the most prevalent causes of anaemia in our environment. However, there is not established reference range of this diagnostic marker sTfR in our environment. There is an important need to devise a screening tool for early detection of iron deficiency before onset of anaemia.
Aims
To determine the sTfR levels of apparently healthy adults in Port Harcourt, Nigeria, determine the reference range of sTfR in the study population.
Methods
This is a descriptive cross sectional study conducted at the University of Port Harcourt Teaching Hospital. one hundred and fifty participants (107 males and 43 females) who satisfied the inclusion criteria were enrolled in this study. The ages of the study population were grouped into four: 21-30, 31-40, 41-50, 51-60. Full blood count and sTfR concentration were assyed on anticoagulated blood samples using a 3- part autoanalyser (sysmex -KX2IN) and Human ELISA kit by biovendor respectively. The results were analysed using SPSS version 21. P value of <0.05 was considered significant.
Results
The mean sTfR concentration of the study population was 0.89±0.46ug/mL with a range of 0.3- 3.05ug/ml. The mean value of sTfR for males and females were 0.92±0.49ug/ml and 0.82±0.37ug/ml. The mean sTfR for age group 21-30 was 0.88+/-0.48ug/ml and 0.80+/-0.47ug/ml for males and females respectively, while the mean sTfR for age group 51- 60 was 0.98+/- 0.53 ug/ml and 0.97+/-0.13ug/ml for males and females respectively. The mean sTfR levels did not differ significantly for age and sex.
Conclusion
This is the first cross sectional study in our environment to determine reference value of sTfR levels in healthy adults in Port harcourt. This reference value was established as 0.3-3-05ug/ml. This study found no statistically significant relationship between different ages and sexes.
Session topic: 28. Iron metabolism, deficiency and overload
Keyword(s): Transferrin receptor, Screening, iron deficiency, Healthy individuals
Abstract: PB1909
Type: Publication Only
Background
soluble transferrin receptor (sTfR) is an early marker of tissue iron deficiency before onset of anaemia. sTfR is one of the noninvasive tools for early diagnosis of iron deficiency anaemia, which is one of the most prevalent causes of anaemia in our environment. However, there is not established reference range of this diagnostic marker sTfR in our environment. There is an important need to devise a screening tool for early detection of iron deficiency before onset of anaemia.
Aims
To determine the sTfR levels of apparently healthy adults in Port Harcourt, Nigeria, determine the reference range of sTfR in the study population.
Methods
This is a descriptive cross sectional study conducted at the University of Port Harcourt Teaching Hospital. one hundred and fifty participants (107 males and 43 females) who satisfied the inclusion criteria were enrolled in this study. The ages of the study population were grouped into four: 21-30, 31-40, 41-50, 51-60. Full blood count and sTfR concentration were assyed on anticoagulated blood samples using a 3- part autoanalyser (sysmex -KX2IN) and Human ELISA kit by biovendor respectively. The results were analysed using SPSS version 21. P value of <0.05 was considered significant.
Results
The mean sTfR concentration of the study population was 0.89±0.46ug/mL with a range of 0.3- 3.05ug/ml. The mean value of sTfR for males and females were 0.92±0.49ug/ml and 0.82±0.37ug/ml. The mean sTfR for age group 21-30 was 0.88+/-0.48ug/ml and 0.80+/-0.47ug/ml for males and females respectively, while the mean sTfR for age group 51- 60 was 0.98+/- 0.53 ug/ml and 0.97+/-0.13ug/ml for males and females respectively. The mean sTfR levels did not differ significantly for age and sex.
Conclusion
This is the first cross sectional study in our environment to determine reference value of sTfR levels in healthy adults in Port harcourt. This reference value was established as 0.3-3-05ug/ml. This study found no statistically significant relationship between different ages and sexes.
Session topic: 28. Iron metabolism, deficiency and overload
Keyword(s): Transferrin receptor, Screening, iron deficiency, Healthy individuals