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THE RELATIONSHIP ENDOTHELIAL MICROPARTICLES AND ASYMMETRIC DIMETIL ARGININE IN CHILDREN WITH IRON DEFICIENCY AND IRON DEFICIENCY ANEMIA
Author(s):
Emine Kaygı Tartıcı
,
Emine Kaygı Tartıcı
Affiliations:
Pediatrics,Medical Health University,Kayseri,Turkey
Yasemin Altuner Torun
,
Yasemin Altuner Torun
Affiliations:
Pediatric Hematology,Medical Health University,Kayseri,Turkey
Cigdem Karakukucu
,
Cigdem Karakukucu
Affiliations:
Biochemistry,Medical Health University,Kayseri,Turkey
Serkan Celik
,
Serkan Celik
Affiliations:
Pediatric Cardiology,Medical Health University,Kayseri,Turkey
Hatice Tuna Hormet Oz
Hatice Tuna Hormet Oz
Affiliations:
Microbiology,Medical Health University,Kayseri,Turkey
(Abstract release date: 05/18/17) EHA Library. ALTUNER TORUN Y. 05/18/17; 182621; PB1907
Yasemin ALTUNER TORUN
Yasemin ALTUNER TORUN
Contributions
PDF Abstract
Abstract

Abstract: PB1907

Type: Publication Only

Background
Iron deficiency anemia and iron deficiency without anemia increase the risk of atherosclerosis by increasing oxidative stress and inflammation. Endothelial dysfunction is an important factor of the pathogenesis of atherosclerosis.

Aims

Endothelial micro particles (EMPs) are considered as markers of endothelial dysfunction. Asymmetric dimetil arginine (ADMA) is known as another marker of endothelial dysfunction. In this study; we aimed to evaluate circulating EMPs and ADMA in children with iron deficiency and iron deficiency anemia and to disclose iron deficiency with the strongest relation with EMPs, ADMA and carotid atherosclerosis.

Methods

This study included 30 children with iron deficiency anemia, 30 children with iron deficiency without anemia and 30 healthy children whose anthropometrics measurements were recorded. Hemoglobin, serum iron level, iron binding capacity, ferritin, and lipid profile were studied. Circulating EMPs (CD144, CD146, and CD105) were measured by flow cytometry. ADMA was measured by ELİSA. The carotid artery intima media thickness (CIMT) and left ventricular mass index (LVMI) were measured using echocardiography.

Results
CD144 and CD105 EMP levels were lower in the iron deficiency without anemia group than in the control group and statically lower than in the iron deficiency anemia group (p<0.05). There were no significant differences in ADMA level between groups. Any significant variety in ADMA level was not observed between groups. CIMT was negative correlated with ferritin and high density lipoprotein and positive correlated with body weight.

Conclusion

In this study, endothelial dysfunction which occurs as a result of iron deficiency were observed. According to our result, CD144 and CD105 EMP levels in the iron deficiency without anemia group were lower than the iron deficiency anemia and control group; these levels in iron deficiency anemia group were higher than control group. In addition, when the level of ferritin has decreased, CIMT has increased. This study show that CD144 and CD105 may be related to endothelial dysfunction which occurs by iron deficiency.

Session topic: 28. Iron metabolism, deficiency and overload

Keyword(s): Microparticles, iron deficiency

Abstract: PB1907

Type: Publication Only

Background
Iron deficiency anemia and iron deficiency without anemia increase the risk of atherosclerosis by increasing oxidative stress and inflammation. Endothelial dysfunction is an important factor of the pathogenesis of atherosclerosis.

Aims

Endothelial micro particles (EMPs) are considered as markers of endothelial dysfunction. Asymmetric dimetil arginine (ADMA) is known as another marker of endothelial dysfunction. In this study; we aimed to evaluate circulating EMPs and ADMA in children with iron deficiency and iron deficiency anemia and to disclose iron deficiency with the strongest relation with EMPs, ADMA and carotid atherosclerosis.

Methods

This study included 30 children with iron deficiency anemia, 30 children with iron deficiency without anemia and 30 healthy children whose anthropometrics measurements were recorded. Hemoglobin, serum iron level, iron binding capacity, ferritin, and lipid profile were studied. Circulating EMPs (CD144, CD146, and CD105) were measured by flow cytometry. ADMA was measured by ELİSA. The carotid artery intima media thickness (CIMT) and left ventricular mass index (LVMI) were measured using echocardiography.

Results
CD144 and CD105 EMP levels were lower in the iron deficiency without anemia group than in the control group and statically lower than in the iron deficiency anemia group (p<0.05). There were no significant differences in ADMA level between groups. Any significant variety in ADMA level was not observed between groups. CIMT was negative correlated with ferritin and high density lipoprotein and positive correlated with body weight.

Conclusion

In this study, endothelial dysfunction which occurs as a result of iron deficiency were observed. According to our result, CD144 and CD105 EMP levels in the iron deficiency without anemia group were lower than the iron deficiency anemia and control group; these levels in iron deficiency anemia group were higher than control group. In addition, when the level of ferritin has decreased, CIMT has increased. This study show that CD144 and CD105 may be related to endothelial dysfunction which occurs by iron deficiency.

Session topic: 28. Iron metabolism, deficiency and overload

Keyword(s): Microparticles, iron deficiency

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