Contributions
Abstract: PB1899
Type: Publication Only
Background
The intense chemotherapic regimens and hypometilant agents to treat acute leukemia induce prolonged neutropenia with high risk of infections.
Aims
To analize local microbial epidemiology we studied patients admitted to our ward.
Methods
All 100 cases of Acute Leukemia (AL) admitted in our ward from august 2013 to February 2017 received prophylactic antibacterial therapy with fluoroquinolones and were analized for weekly routine tissue colture screening and serial blood colture for fever.
Results
We found 28 patients (28%) bacterial septic shock during fever, of which 20 cases gram negative (71%) in particular 65% E.Coli, 15% Enterobacter, 10% Klembsiella, 5% Stenotrophomonas, 5% Pseudomonas; while 8 patients(29%) had a gram positive septic shock (S.Haemoliticus 38%, S.capitis 25%, S. hominis 25%, S epidermidis 12%). During intensive chemotherapy and prolonged severe neutropenia we took over the major incidence of septic shock (23 patients 82%) than hypometilant treatment in particular decitabine (5 patients 18%). During 2014 we had 3 mortal septic shock for multiresistant gram- klembsiella and Pseudomonas. Since than we adopted in our ward, isolation of patients with gram negative (klembsiella or pseudomonas )tissue colture positive, hygenic and sanitary practices with closing room for 48 hours and hand disinfection before entering and after leaving any patients room.We noticed a change of bacterial infections incidence in these 3 years in our ward.:reduction klembsiella /pseudomonas multiresistant infections and emergency of E.coli and Staphilococcus septic shock not multiresistant.
Conclusion
More epidemiological analysis in several haematological ward are necessary to understand if it is a changing local microbial epidemiology or is the different management of neutropenic patients with acute leukemia and /or a different antimicrobial strategy to determine this changing trend.
Session topic: 29. Infectious diseases, supportive care
Abstract: PB1899
Type: Publication Only
Background
The intense chemotherapic regimens and hypometilant agents to treat acute leukemia induce prolonged neutropenia with high risk of infections.
Aims
To analize local microbial epidemiology we studied patients admitted to our ward.
Methods
All 100 cases of Acute Leukemia (AL) admitted in our ward from august 2013 to February 2017 received prophylactic antibacterial therapy with fluoroquinolones and were analized for weekly routine tissue colture screening and serial blood colture for fever.
Results
We found 28 patients (28%) bacterial septic shock during fever, of which 20 cases gram negative (71%) in particular 65% E.Coli, 15% Enterobacter, 10% Klembsiella, 5% Stenotrophomonas, 5% Pseudomonas; while 8 patients(29%) had a gram positive septic shock (S.Haemoliticus 38%, S.capitis 25%, S. hominis 25%, S epidermidis 12%). During intensive chemotherapy and prolonged severe neutropenia we took over the major incidence of septic shock (23 patients 82%) than hypometilant treatment in particular decitabine (5 patients 18%). During 2014 we had 3 mortal septic shock for multiresistant gram- klembsiella and Pseudomonas. Since than we adopted in our ward, isolation of patients with gram negative (klembsiella or pseudomonas )tissue colture positive, hygenic and sanitary practices with closing room for 48 hours and hand disinfection before entering and after leaving any patients room.We noticed a change of bacterial infections incidence in these 3 years in our ward.:reduction klembsiella /pseudomonas multiresistant infections and emergency of E.coli and Staphilococcus septic shock not multiresistant.
Conclusion
More epidemiological analysis in several haematological ward are necessary to understand if it is a changing local microbial epidemiology or is the different management of neutropenic patients with acute leukemia and /or a different antimicrobial strategy to determine this changing trend.
Session topic: 29. Infectious diseases, supportive care