Contributions
Abstract: PB1874
Type: Publication Only
Background
Follicular lymphoma (FL) is an indolent lymphoid B neoplasm corresponding to 20-25% of non-Hodgkin lymphomas (NHL). Bone marrow biopsy (BMB) is part of standard work-up in indolent NHL since up to 40-70% of cases have bone marrow infiltration. This fact is important, so advance stage is one factor considered in the FLIPI-1 and FLIPI-2 prognostic index. Positron emission tomography/computed tomography (PET-CT) is a noninvasive technique that shows high sensitivity of detecting nodal and extranodal lymphoma involvement. specially in aggressive subtypes. Some studies have described a high sensitivity (62-100%) and specificity (96-100%) in the detection of bone marrow involvement in agressive NHL. However, its role in low-grade indolent lymphoma such as folicular lymphoma remains controversial.
Aims
To analyze retrospectively the diagnostic accuracy of PET-CT in comparision with BMB in the initial staging of new FL in a single centre in daily practice.
Methods
Results
Thirty-five male and 29 female were included. The median age at diagnosis: 58 years (range 23-84 ). Thirty-four patients had grade 1-2 FL and 30 grade 3a FL. Bone marrow involvement was diagnosed in 33 of 64 patients (51.1%) by BMB. Out of the 17 patients with positive PET-CT, 4 had negative BMB. Out of 33 patients with positive BMB, 13 had a positive PET-CT (Table 1). The sensitivity and specificity of PET-CT was 39% and 87%, respectively. The positive predictive value and negative predictive value was 76.5% and 57%, respectively.
Conclusion
Session topic: 19. Indolent Non-Hodgkin lymphoma - Clinical
Keyword(s): PET, Follicular lymphoma, Bone marrow biopsy, Staging
Abstract: PB1874
Type: Publication Only
Background
Follicular lymphoma (FL) is an indolent lymphoid B neoplasm corresponding to 20-25% of non-Hodgkin lymphomas (NHL). Bone marrow biopsy (BMB) is part of standard work-up in indolent NHL since up to 40-70% of cases have bone marrow infiltration. This fact is important, so advance stage is one factor considered in the FLIPI-1 and FLIPI-2 prognostic index. Positron emission tomography/computed tomography (PET-CT) is a noninvasive technique that shows high sensitivity of detecting nodal and extranodal lymphoma involvement. specially in aggressive subtypes. Some studies have described a high sensitivity (62-100%) and specificity (96-100%) in the detection of bone marrow involvement in agressive NHL. However, its role in low-grade indolent lymphoma such as folicular lymphoma remains controversial.
Aims
To analyze retrospectively the diagnostic accuracy of PET-CT in comparision with BMB in the initial staging of new FL in a single centre in daily practice.
Methods
Results
Thirty-five male and 29 female were included. The median age at diagnosis: 58 years (range 23-84 ). Thirty-four patients had grade 1-2 FL and 30 grade 3a FL. Bone marrow involvement was diagnosed in 33 of 64 patients (51.1%) by BMB. Out of the 17 patients with positive PET-CT, 4 had negative BMB. Out of 33 patients with positive BMB, 13 had a positive PET-CT (Table 1). The sensitivity and specificity of PET-CT was 39% and 87%, respectively. The positive predictive value and negative predictive value was 76.5% and 57%, respectively.
Conclusion
Session topic: 19. Indolent Non-Hodgkin lymphoma - Clinical
Keyword(s): PET, Follicular lymphoma, Bone marrow biopsy, Staging