Contributions
Abstract: PB1873
Type: Publication Only
Background
FL represents 70% of all indolent non-Hodgkin lymphomas, and it is widely recognized that FL is a heterogeneous disease, with patients presenting with differing amounts of tumor burden and prognostic indicators. The NCCN guideline recommends using rituximab as a single agent or in combination with other chemotherapies as first-line therapy (1LT) or second-line therapy (2LT). No recommendations are provided beyond 2LT.
Aims
To evaluate treatment patterns and associated response in patients with newly diagnosed FL in routine care in the US.
Methods
Newly diagnosed FL patients aged ≥18 years were selected from Humedica, a large, national US EMR database, between 01/01/08 and 07/31/15 if they had ≥1 inpatient record or ≥2 outpatient records with FL diagnosis codes. The date of the first FL record was the index date. Patients were followed from index until end of continuous activity, progression to diffuse large B-cell lymphoma (DLBCL), death, or end of study period (09/30/15) and were evaluated for FL treatment patterns and treatment response. Possible remission was defined as no additional chemotherapy and no supportive care use or receipt of supportive care <30 days after end of line of therapy (LOT) for <30 days. Lack of remission was defined as receipt of supportive care <30 days after end of LOT for >30 days. Progression was defined as initiation of another LOT, transition to DLBCL, or evidence of supportive care >30 days after end of LOT.
Results
Conclusion
Session topic: 19. Indolent Non-Hodgkin lymphoma - Clinical
Keyword(s): Treatment, Outcome, Follicular lymphoma
Abstract: PB1873
Type: Publication Only
Background
FL represents 70% of all indolent non-Hodgkin lymphomas, and it is widely recognized that FL is a heterogeneous disease, with patients presenting with differing amounts of tumor burden and prognostic indicators. The NCCN guideline recommends using rituximab as a single agent or in combination with other chemotherapies as first-line therapy (1LT) or second-line therapy (2LT). No recommendations are provided beyond 2LT.
Aims
To evaluate treatment patterns and associated response in patients with newly diagnosed FL in routine care in the US.
Methods
Newly diagnosed FL patients aged ≥18 years were selected from Humedica, a large, national US EMR database, between 01/01/08 and 07/31/15 if they had ≥1 inpatient record or ≥2 outpatient records with FL diagnosis codes. The date of the first FL record was the index date. Patients were followed from index until end of continuous activity, progression to diffuse large B-cell lymphoma (DLBCL), death, or end of study period (09/30/15) and were evaluated for FL treatment patterns and treatment response. Possible remission was defined as no additional chemotherapy and no supportive care use or receipt of supportive care <30 days after end of line of therapy (LOT) for <30 days. Lack of remission was defined as receipt of supportive care <30 days after end of LOT for >30 days. Progression was defined as initiation of another LOT, transition to DLBCL, or evidence of supportive care >30 days after end of LOT.
Results
Conclusion
Session topic: 19. Indolent Non-Hodgkin lymphoma - Clinical
Keyword(s): Treatment, Outcome, Follicular lymphoma