Contributions
Abstract: PB1801
Type: Publication Only
Background
Monoclonal B-cell lymphocytosis (MBL) is a recently recognized entity characterized by the presence, in the peripheral blood, of a monoclonal B-cell population lower than 5000/µl, in the absence of any type of clinical features. MBL clones may have: a) chronic lymphocytic leukemia (CLL-like) phenotype (CD5+, CD19+, CD23+, CD20 dim); b) atypical CLL phenotype (CD5+, CD19+, CD23- or CD20 bright); c) non-CLL phenotype (CD5-). MBL can be also distinguished in “low-count” (<500/µl) and “high-count” (>500/µl) subtypes. High-count MBL frequently shows typical CLL phenotypic/genetic features and require adequate follow-up in order to detect their possible evolution into symptomatic CLL. MBL showing a clonal B-cell count higher than 1000-1500/µl are usually defined “clinical” MBL.
Aims
To study prospectively the frequency of CLL-like MBL clones in patients affected by PC compared to healthy males of the same ages, after our previous occasional observation of an apparently increased MBL incidence at baseline in a cohort of patients with PC originally studied to detect lymphocyte abnormalities possibly induced by radiotherapy (RT).
Methods
Results
Median (range) absolute counts of white blood cells (WBC), total lymphocytes and B-cells, as well as absolute single values of MBL clones are reported in Table 1.
Conclusion
The preliminary results of our prospective study, performed using a routine, not highly sensitive flow cytometry approach, highlight a possible association between (clinical?) MBL and PC, never described before and probably warranting further investigation in a larger number of patients.
Session topic: 6. Chronic lymphocytic leukemia and related disorders - Clinical
Keyword(s): Prostate, B cell subsets
Abstract: PB1801
Type: Publication Only
Background
Monoclonal B-cell lymphocytosis (MBL) is a recently recognized entity characterized by the presence, in the peripheral blood, of a monoclonal B-cell population lower than 5000/µl, in the absence of any type of clinical features. MBL clones may have: a) chronic lymphocytic leukemia (CLL-like) phenotype (CD5+, CD19+, CD23+, CD20 dim); b) atypical CLL phenotype (CD5+, CD19+, CD23- or CD20 bright); c) non-CLL phenotype (CD5-). MBL can be also distinguished in “low-count” (<500/µl) and “high-count” (>500/µl) subtypes. High-count MBL frequently shows typical CLL phenotypic/genetic features and require adequate follow-up in order to detect their possible evolution into symptomatic CLL. MBL showing a clonal B-cell count higher than 1000-1500/µl are usually defined “clinical” MBL.
Aims
To study prospectively the frequency of CLL-like MBL clones in patients affected by PC compared to healthy males of the same ages, after our previous occasional observation of an apparently increased MBL incidence at baseline in a cohort of patients with PC originally studied to detect lymphocyte abnormalities possibly induced by radiotherapy (RT).
Methods
Results
Median (range) absolute counts of white blood cells (WBC), total lymphocytes and B-cells, as well as absolute single values of MBL clones are reported in Table 1.
Conclusion
The preliminary results of our prospective study, performed using a routine, not highly sensitive flow cytometry approach, highlight a possible association between (clinical?) MBL and PC, never described before and probably warranting further investigation in a larger number of patients.
Session topic: 6. Chronic lymphocytic leukemia and related disorders - Clinical
Keyword(s): Prostate, B cell subsets