Contributions
Abstract: PB1795
Type: Publication Only
Background
The specific determining factors for malignant progression in Chronic lymphocytic leukemia (CLL ), remaining unknown.
Aims
To investigat the potential existence of unique cytogenetic profiles associated with specific IGHV repertoires that could be associated with an increased risk of progression in CLL.
Methods
For this purpose, molecular analysis of well-established cytogenetic alterations of chromosomes 11, 12, 13, 14 and 17 together with the pattern of rearrangement of the IGHV genes were performed in 100 CLL cases.
Results
Our results based on molecular analysis from 100 subjects living in the same geographical area, show the presence of three major groups of clones with distinct but partially overlying configurations of IGHV gene usage, IGHV mutational status and cytogenetic alterations. These included a group which mainly consisted of clinical advanced stage CLL with a skewed but different CLL-associated IGHV gene repertoire
Conclusion
These findings suggest that the specific IGHV repertoire and IGHV mutational status of CLL B-cell clones may adjust the type of cytogenetic alterations acquired and their clinical significances. Further long-term follow-up studies investigating the IGHV gene repertoire of CLL clones in distinct geographic areas and microenvironments are required to validate our findings and discard or confirm the potential role of some antigen-binding BCR specificities contributing to clonal evolution.
Session topic: 6. Chronic lymphocytic leukemia and related disorders - Clinical
Keyword(s): prognosis, Mutation status, Genetic, B cell chronic lymphocytic leukemia
Abstract: PB1795
Type: Publication Only
Background
The specific determining factors for malignant progression in Chronic lymphocytic leukemia (CLL ), remaining unknown.
Aims
To investigat the potential existence of unique cytogenetic profiles associated with specific IGHV repertoires that could be associated with an increased risk of progression in CLL.
Methods
For this purpose, molecular analysis of well-established cytogenetic alterations of chromosomes 11, 12, 13, 14 and 17 together with the pattern of rearrangement of the IGHV genes were performed in 100 CLL cases.
Results
Our results based on molecular analysis from 100 subjects living in the same geographical area, show the presence of three major groups of clones with distinct but partially overlying configurations of IGHV gene usage, IGHV mutational status and cytogenetic alterations. These included a group which mainly consisted of clinical advanced stage CLL with a skewed but different CLL-associated IGHV gene repertoire
Conclusion
These findings suggest that the specific IGHV repertoire and IGHV mutational status of CLL B-cell clones may adjust the type of cytogenetic alterations acquired and their clinical significances. Further long-term follow-up studies investigating the IGHV gene repertoire of CLL clones in distinct geographic areas and microenvironments are required to validate our findings and discard or confirm the potential role of some antigen-binding BCR specificities contributing to clonal evolution.
Session topic: 6. Chronic lymphocytic leukemia and related disorders - Clinical
Keyword(s): prognosis, Mutation status, Genetic, B cell chronic lymphocytic leukemia