Contributions
Abstract: PB1793
Type: Publication Only
Background
In recent times, several powerful prognostic scores have been developed in order to predict time to first treatment (TTFT) and overall survival (OS) of patients with chronic lymphocytic leukemia (CLL). The international prognostic index for chronic lymphocytic leukemia (CLL-IPI) developed by The International CLL-IPI working group was found to predict OS and TTFT, while the rest of two scores- progression-risk score (PRS) and MD Anderson Cancer Center Score 2011 (MDACC 2011) have been developed for prediction of TTFT in early stage CLL patients.
Aims
The aim of this study was to compare CLL-IPI, PRS and MDACC 2011 prognostic scores based on their impact on TTFT, treatment response (TR), progression-free survival (PFS) and OS of 54 treated CLL patients.
Methods
We retrospectively analyzed data from 54 consecutive CLL patients diagnosed and treated at Clinic for Hematology, Clinical Center of Serbia from 2003 to 2013. Blood samples were prospectively collected and analyzed for biological and molecular features (IGHV, FISH and TP53), as well as standard laboratory parameters. The three scores were retrospectively calculated using formulas from the original articles (International CLL-IPI working group, Lancet Oncol 2016, for CLL-IPI; Gentile et al, Leukemia 2016, for PRS; and Wierda et al, J Clin Oncol 2011, for MDACC 2011 score), and, than, correlated with TTFT, TR, PFS and OS of patients from the studied cohort.
Results
Median age at diagnosis was 57 years (range 38-75). All patients were treated with fludarabin-based chemotherapy, 45 (83%) in the first treatment line. Overall response rate to the first line therapy was 81%, equally distributed on complete and partial responses. Most of the patients (42, 78%) relapsed during the follow up. At the time of the last follow up 14 (26%) patients were still alive, 35 (65%) were dead, and 5 (9%) were lost to follow up. Median overal survival was 76 months.
Conclusion
CLL-IPI and PRS were identified as significant predictors of TTFT, as well as of duration of TR and OS. Further studies are warranted to confirm these findings.
Session topic: 6. Chronic lymphocytic leukemia and related disorders - Clinical
Keyword(s): International prognostic index, Fludarabine, Chronic Lymphocytic Leukemia
Abstract: PB1793
Type: Publication Only
Background
In recent times, several powerful prognostic scores have been developed in order to predict time to first treatment (TTFT) and overall survival (OS) of patients with chronic lymphocytic leukemia (CLL). The international prognostic index for chronic lymphocytic leukemia (CLL-IPI) developed by The International CLL-IPI working group was found to predict OS and TTFT, while the rest of two scores- progression-risk score (PRS) and MD Anderson Cancer Center Score 2011 (MDACC 2011) have been developed for prediction of TTFT in early stage CLL patients.
Aims
The aim of this study was to compare CLL-IPI, PRS and MDACC 2011 prognostic scores based on their impact on TTFT, treatment response (TR), progression-free survival (PFS) and OS of 54 treated CLL patients.
Methods
We retrospectively analyzed data from 54 consecutive CLL patients diagnosed and treated at Clinic for Hematology, Clinical Center of Serbia from 2003 to 2013. Blood samples were prospectively collected and analyzed for biological and molecular features (IGHV, FISH and TP53), as well as standard laboratory parameters. The three scores were retrospectively calculated using formulas from the original articles (International CLL-IPI working group, Lancet Oncol 2016, for CLL-IPI; Gentile et al, Leukemia 2016, for PRS; and Wierda et al, J Clin Oncol 2011, for MDACC 2011 score), and, than, correlated with TTFT, TR, PFS and OS of patients from the studied cohort.
Results
Median age at diagnosis was 57 years (range 38-75). All patients were treated with fludarabin-based chemotherapy, 45 (83%) in the first treatment line. Overall response rate to the first line therapy was 81%, equally distributed on complete and partial responses. Most of the patients (42, 78%) relapsed during the follow up. At the time of the last follow up 14 (26%) patients were still alive, 35 (65%) were dead, and 5 (9%) were lost to follow up. Median overal survival was 76 months.
Conclusion
CLL-IPI and PRS were identified as significant predictors of TTFT, as well as of duration of TR and OS. Further studies are warranted to confirm these findings.
Session topic: 6. Chronic lymphocytic leukemia and related disorders - Clinical
Keyword(s): International prognostic index, Fludarabine, Chronic Lymphocytic Leukemia