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MULTIPLE NEOPLASMS CONSIST OF SOLID CANCER AND NON-HODGKIN LYMPHOMA
Author(s): ,
Kazuhiko Natori
Affiliations:
hematology and Oncology,Toho University Medical Center,Oota city,Japan
,
Daisuke Nagase
Affiliations:
hematology and Oncology,Toho University Medical Center,Oota city,Japan
,
Susumu Ishihara
Affiliations:
hematology and Oncology,Toho University Medical Center,Oota city,Japan
,
Akiko Shibuya
Affiliations:
hematology and Oncology,Toho University Medical Center,Oota city,Japan
,
Yurika Mitsui
Affiliations:
hematology and Oncology,Toho University Medical Center,Oota city,Japan
,
Yasunobu Kuraishi
Affiliations:
hematology and Oncology,Toho University Medical Center,Oota city,Japan
Haruka Izumi
Affiliations:
hematology and Oncology,Toho University Medical Center,Oota city,Japan
(Abstract release date: 05/18/17) EHA Library. Natori K. 05/18/17; 182445; PB1731
K Natori
K Natori
Contributions
Abstract

Abstract: PB1731

Type: Publication Only

Background
Malignant lymphoma is a nineth cause of death in Japan. And non-Hodgkin lymphoma(NHL) occupied more than 90%. We experienced cases and will report that we reviewed multiple neoplasms consisting non-Hodgkin lymphoma. We experienced 176 cases.

Aims
We aimed for epidemiology and prognosis improvement of malignant neoplasms including NHL. We want to look for a hint of the early detection.

Methods
We intended for multiple neoplasms 340 cases including hematological malignancy. We reviewed 190 cases of multiple neoplasms including malignant lymphoma. In 190 cases, NHL case were 176 cases. The examination factors are type of the hematological malignancy, gender, the age at onset of the first cancer, interval with the second cancer, treatment strategy. The definition of multiple neoplasms followed Warren & Gates theory. And as for the definition of synchronous type, a diagnosis interval is less than 6 months, metachronous type interval is more than 6 months. About statistical examination, we used SPSS statistics ver21.

Results
All cases are 176 cases, consist of male 108 cases, female 68 cases, synchronous type 45 cases, metachronous type 131 cases. Double neoplasms 149 cases, triple neoplasms 25 cases, quadple neoplasms 2 cases. The median age was 71yrs (ranged51-93yrs), the synchronous type 70yrs(ranged 51-88years), the metachronous type was 73yrs(ranged 57-93yrs). The counterpart of malignancies, Hodgkin’s lymphoma 1 case, myelodysplastic syndrome 3 cases, acute myeloid leukemia 8 cases, multiple myeloma 4 cases, gastric cancer 38 cases, colon cancer 32 cases, lung cancer 26 cases, renal cell carcinoma 6 cases, prostate cancer 12 cases, breast cancer 14 cases, urinal bladder cancer 5 cases, uterin cancer 7 cases, esophangeal cancer 9 cases, hepatocellar carcinoma 12 cases.

In double neoplasms was 149 cases, metachronous type was 112 cases. The median age of first diagnosis, 68yrs (ranged43-85yrs), the second cancer were 74yrs (ranged57-89yrs), About interval between solid cancer and NHL, median interval time was 58M, solid cancer precedence case was 53 cases, interval was 81M (ranged 7-564M), hematological malignancy precedence case was 59 cases interval was 55M (ranged 8-364M). The cause of death was that 15 cases were solid cancer, 72 cases were hematological malignancy and 6 cases were accident. The median overall survival was 18M( ranged 1-211M), synchronous type 14M(ranged 2-132M), metachronous type 22M (ranged1-116M).

Conclusion
In the case of a double cancer including solid cancer and NHL, the first cancer occurs in elderly. Diagnosis of malignant neoplasms within 3 years were 48 cases out of 149 cases(32.2%). The important point is that 3 years are required for careful observation at the time of malignancy diagnosis. It is nessessary to discover at the early stage. So it could be a lot of treatment options formalignant neoplasms. We think that a prognosis is improved.

Session topic: 20. Aggressive Non-Hodgkin lymphoma - Clinical

Keyword(s): NHL

Abstract: PB1731

Type: Publication Only

Background
Malignant lymphoma is a nineth cause of death in Japan. And non-Hodgkin lymphoma(NHL) occupied more than 90%. We experienced cases and will report that we reviewed multiple neoplasms consisting non-Hodgkin lymphoma. We experienced 176 cases.

Aims
We aimed for epidemiology and prognosis improvement of malignant neoplasms including NHL. We want to look for a hint of the early detection.

Methods
We intended for multiple neoplasms 340 cases including hematological malignancy. We reviewed 190 cases of multiple neoplasms including malignant lymphoma. In 190 cases, NHL case were 176 cases. The examination factors are type of the hematological malignancy, gender, the age at onset of the first cancer, interval with the second cancer, treatment strategy. The definition of multiple neoplasms followed Warren & Gates theory. And as for the definition of synchronous type, a diagnosis interval is less than 6 months, metachronous type interval is more than 6 months. About statistical examination, we used SPSS statistics ver21.

Results
All cases are 176 cases, consist of male 108 cases, female 68 cases, synchronous type 45 cases, metachronous type 131 cases. Double neoplasms 149 cases, triple neoplasms 25 cases, quadple neoplasms 2 cases. The median age was 71yrs (ranged51-93yrs), the synchronous type 70yrs(ranged 51-88years), the metachronous type was 73yrs(ranged 57-93yrs). The counterpart of malignancies, Hodgkin’s lymphoma 1 case, myelodysplastic syndrome 3 cases, acute myeloid leukemia 8 cases, multiple myeloma 4 cases, gastric cancer 38 cases, colon cancer 32 cases, lung cancer 26 cases, renal cell carcinoma 6 cases, prostate cancer 12 cases, breast cancer 14 cases, urinal bladder cancer 5 cases, uterin cancer 7 cases, esophangeal cancer 9 cases, hepatocellar carcinoma 12 cases.

In double neoplasms was 149 cases, metachronous type was 112 cases. The median age of first diagnosis, 68yrs (ranged43-85yrs), the second cancer were 74yrs (ranged57-89yrs), About interval between solid cancer and NHL, median interval time was 58M, solid cancer precedence case was 53 cases, interval was 81M (ranged 7-564M), hematological malignancy precedence case was 59 cases interval was 55M (ranged 8-364M). The cause of death was that 15 cases were solid cancer, 72 cases were hematological malignancy and 6 cases were accident. The median overall survival was 18M( ranged 1-211M), synchronous type 14M(ranged 2-132M), metachronous type 22M (ranged1-116M).

Conclusion
In the case of a double cancer including solid cancer and NHL, the first cancer occurs in elderly. Diagnosis of malignant neoplasms within 3 years were 48 cases out of 149 cases(32.2%). The important point is that 3 years are required for careful observation at the time of malignancy diagnosis. It is nessessary to discover at the early stage. So it could be a lot of treatment options formalignant neoplasms. We think that a prognosis is improved.

Session topic: 20. Aggressive Non-Hodgkin lymphoma - Clinical

Keyword(s): NHL

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