PRIMARY ADRENAL LYMPHOMA: A SINGLE-CENTER EXPERIENCE
(Abstract release date: 05/18/17)
EHA Library. YUAN L. 05/18/17; 182435; PB1721
LEI YUAN
Contributions
Contributions
Abstract
Abstract: PB1721
Type: Publication Only
Background
Primary adrenal lymphoma (PAL) is rare, with slightly more than 250 cases currently described in the English-language literature. In current classifications, there is not yet a consensual definition of PAL.
Aims
The aim of this study was to report a large single-center clinical case series of primary adrenal lymphoma (PAL) in terms of clinical presentation, pathological and imaging features, and treatment outcome.
Methods
We performed a retrospective analysis of 21 patients diagnosed with PAL who presented to our center between January 2005 and January 2014.
Results
Median age at presentation was 48 years (range: 27–73) with a male-to-female ratio of 5:2. Bilateral and right-sided adrenal involvement were seen in 12/21 and 7/21 patients, respectively. Adrenal insufficiency (AI) was seen in 6/10 evaluated patients. Computed tomography scans showed slight to moderate contrast enhancement of adrenal masses in 4/5 patients (80%), and magnetic resonance imaging identified a normal T1 and longer T2 phase. Diffuse large B cell lymphoma (DLBCL) was the most common immunophenotype (85.6%). Two patients died due to rapid disease progression before treatment. Three patients were treated with chemotherapy ± external beam radiotherapy. Two patients received autologous stem cell transplantation as consolidation therapy. Five-year overall survival and progression-free survival were 54.2% and 51.0%, respectively.
Conclusion
These findings suggest that PAL should always be considered in differential diagnosis of adrenal mass with AI. Moreover, DLBCL was observed as the most common histological subtype of PAL. Despite the contrasting previous reports, long-term prognosis of PAL is not necessarily inferior to that of non-Hodgkin lymphoma in general.
Session topic: 20. Aggressive Non-Hodgkin lymphoma - Clinical
Abstract: PB1721
Type: Publication Only
Background
Primary adrenal lymphoma (PAL) is rare, with slightly more than 250 cases currently described in the English-language literature. In current classifications, there is not yet a consensual definition of PAL.
Aims
The aim of this study was to report a large single-center clinical case series of primary adrenal lymphoma (PAL) in terms of clinical presentation, pathological and imaging features, and treatment outcome.
Methods
We performed a retrospective analysis of 21 patients diagnosed with PAL who presented to our center between January 2005 and January 2014.
Results
Median age at presentation was 48 years (range: 27–73) with a male-to-female ratio of 5:2. Bilateral and right-sided adrenal involvement were seen in 12/21 and 7/21 patients, respectively. Adrenal insufficiency (AI) was seen in 6/10 evaluated patients. Computed tomography scans showed slight to moderate contrast enhancement of adrenal masses in 4/5 patients (80%), and magnetic resonance imaging identified a normal T1 and longer T2 phase. Diffuse large B cell lymphoma (DLBCL) was the most common immunophenotype (85.6%). Two patients died due to rapid disease progression before treatment. Three patients were treated with chemotherapy ± external beam radiotherapy. Two patients received autologous stem cell transplantation as consolidation therapy. Five-year overall survival and progression-free survival were 54.2% and 51.0%, respectively.
Conclusion
These findings suggest that PAL should always be considered in differential diagnosis of adrenal mass with AI. Moreover, DLBCL was observed as the most common histological subtype of PAL. Despite the contrasting previous reports, long-term prognosis of PAL is not necessarily inferior to that of non-Hodgkin lymphoma in general.
Session topic: 20. Aggressive Non-Hodgkin lymphoma - Clinical
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