Contributions
Abstract: PB1715
Type: Publication Only
Background
Growing evidences suggest the close relationship between inflammation,
host immunity, and tumor cells. The neutrophil to lymphocyte ratio (NLR) has been
known to predict the prognosis in patients with diffuse large B-cell lymphoma (DLBCL).
Aims
This study was planned to confirm the prognostic and predictive value of NLR and to make a model to predict the prognosis more precisely in patients with DLBCL.
Methods
Data of 192 DLBCL patients treated with R-CHOP from 2004 to 2016 were retrospectively assessed.
Patients with NLR ≥ 4 and < 4 were determined as the high and low NLR groups, respectively. Treatment response and survival were compared according to the NLR status and using the model including NLR and other variable interacting with NLR.
Results
High NLR group was associated with old age, poor performance status (PS), elevated lactate
dehydrogenase, and more advanced prognostic indices than low NLR group. High NLR group had a low complete response (CR) rate compared to low NLR group (57.5% vs. 81.4%, p = 0.004). However, the role of NLR as prognostic factor was not demonstrated on multivariate analysis, which showed strong interaction between NLR and PS. The model composed of NLR and PS could stratify the patients into low-, intermediate-, and high-risk groups for overall survival (OS). On multivariate analysis, compared to low risk group, the hazard ratios of intermediate and high risk groups on OS were 1.871 (p = 0.019) and 2.733 (p = 0.004).
Conclusion
High NLR is associated with poor treatment response and unfavorable clinical features in DLBCL.
The prognostic model using NLR and PS can predict more precisely the prognosis of this population and needs to be validated in the independent cohort.
Session topic: 20. Aggressive Non-Hodgkin lymphoma - Clinical
Keyword(s): Neutrophil, Lymphocyte, Diffuse large B cell lymphoma, prognosis
Abstract: PB1715
Type: Publication Only
Background
Growing evidences suggest the close relationship between inflammation,
host immunity, and tumor cells. The neutrophil to lymphocyte ratio (NLR) has been
known to predict the prognosis in patients with diffuse large B-cell lymphoma (DLBCL).
Aims
This study was planned to confirm the prognostic and predictive value of NLR and to make a model to predict the prognosis more precisely in patients with DLBCL.
Methods
Data of 192 DLBCL patients treated with R-CHOP from 2004 to 2016 were retrospectively assessed.
Patients with NLR ≥ 4 and < 4 were determined as the high and low NLR groups, respectively. Treatment response and survival were compared according to the NLR status and using the model including NLR and other variable interacting with NLR.
Results
High NLR group was associated with old age, poor performance status (PS), elevated lactate
dehydrogenase, and more advanced prognostic indices than low NLR group. High NLR group had a low complete response (CR) rate compared to low NLR group (57.5% vs. 81.4%, p = 0.004). However, the role of NLR as prognostic factor was not demonstrated on multivariate analysis, which showed strong interaction between NLR and PS. The model composed of NLR and PS could stratify the patients into low-, intermediate-, and high-risk groups for overall survival (OS). On multivariate analysis, compared to low risk group, the hazard ratios of intermediate and high risk groups on OS were 1.871 (p = 0.019) and 2.733 (p = 0.004).
Conclusion
High NLR is associated with poor treatment response and unfavorable clinical features in DLBCL.
The prognostic model using NLR and PS can predict more precisely the prognosis of this population and needs to be validated in the independent cohort.
Session topic: 20. Aggressive Non-Hodgkin lymphoma - Clinical
Keyword(s): Neutrophil, Lymphocyte, Diffuse large B cell lymphoma, prognosis