HTLV-1 INFECTION INCREASED THE RISK OF OTHER MALIGNANCY
(Abstract release date: 05/18/17)
EHA Library. Nakaya A. 05/18/17; 182425; PB1711
Dr. Aya Nakaya
Contributions
Contributions
Abstract
Abstract: PB1711
Type: Publication Only
Background
The correlation between HTLV-1 infection and malignant neoplasm other than ATL remains unknown. Some previous studies have indicated that the frequency of primary malignant neoplasms in patients with HTLV-1 seropositive is higher than HTLV-1 seronegative.
Aims
To clarify the correlations between HTLV-1 infection and malignant neoplasms other than ATL.
Methods
We retrospectively analyzed 203 patients with HTLV-1 seropositive who were diagnosed between 2006 and 2015 at Kansai Medical University Hospital.
Results
Among 203 patients (median age 62 years: range 19 to 86 years), 43% was carrier and 57% was diagnosed with ATL. According to clinical subtype, 5% was chronic, 38% was smoldering, 28% was acute, 29 % was lymphoma type. Median overall survival was 30 months in carrier, 10 months in acute, 8 months in lymphoma, and smoldering was not available. In all HTLV-1 seropositive patients, the occurrence of primary malignant neoplasm was 32%, they were all carrier or smoldering. Among them, 53% was hematology malignancy (T cell lymphoma; 41%, B cell lymphoma; 29%, MPN; 18%, MDS; 12%). Solid tumor was 47% (lung cancer; 33%, prostate cancer 13%, colon cancer; 13%, renal cell cancer; 13%). Four patients with HTLV-1 carrier who developed primary malignant neoplasm received standard chemotherapy for the neoplasm, and after the chemotherapy they developed 3 acute type and 1 smoldering type ATL.
Conclusion
In our cohort, the occurrence of primary malignant neoplasm with HTLV-1 seropositive patients was significantly high. Chronic HTLV-1 infection might associate with reduction of cytotoxic T cells and an increased risk of developing other malignancy. Furthermore, cytotoxic chemotherapy for primary malignant neoplasm might reduce cytotoxic T cells for HTLV-1 and exacerbate ATL conditions.
Session topic: 20. Aggressive Non-Hodgkin lymphoma - Clinical
Keyword(s): Malignancy, HTLV-1, ATL
Abstract: PB1711
Type: Publication Only
Background
The correlation between HTLV-1 infection and malignant neoplasm other than ATL remains unknown. Some previous studies have indicated that the frequency of primary malignant neoplasms in patients with HTLV-1 seropositive is higher than HTLV-1 seronegative.
Aims
To clarify the correlations between HTLV-1 infection and malignant neoplasms other than ATL.
Methods
We retrospectively analyzed 203 patients with HTLV-1 seropositive who were diagnosed between 2006 and 2015 at Kansai Medical University Hospital.
Results
Among 203 patients (median age 62 years: range 19 to 86 years), 43% was carrier and 57% was diagnosed with ATL. According to clinical subtype, 5% was chronic, 38% was smoldering, 28% was acute, 29 % was lymphoma type. Median overall survival was 30 months in carrier, 10 months in acute, 8 months in lymphoma, and smoldering was not available. In all HTLV-1 seropositive patients, the occurrence of primary malignant neoplasm was 32%, they were all carrier or smoldering. Among them, 53% was hematology malignancy (T cell lymphoma; 41%, B cell lymphoma; 29%, MPN; 18%, MDS; 12%). Solid tumor was 47% (lung cancer; 33%, prostate cancer 13%, colon cancer; 13%, renal cell cancer; 13%). Four patients with HTLV-1 carrier who developed primary malignant neoplasm received standard chemotherapy for the neoplasm, and after the chemotherapy they developed 3 acute type and 1 smoldering type ATL.
Conclusion
In our cohort, the occurrence of primary malignant neoplasm with HTLV-1 seropositive patients was significantly high. Chronic HTLV-1 infection might associate with reduction of cytotoxic T cells and an increased risk of developing other malignancy. Furthermore, cytotoxic chemotherapy for primary malignant neoplasm might reduce cytotoxic T cells for HTLV-1 and exacerbate ATL conditions.
Session topic: 20. Aggressive Non-Hodgkin lymphoma - Clinical
Keyword(s): Malignancy, HTLV-1, ATL
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