Contributions
Abstract: PB1693
Type: Publication Only
Background
Aims
Methods
Patients diagnosed with BPDCN at the National Hematology Hospital between 2010 and 2016 were retrieved from the database. The diagnosis was confirmed by morphology and immunophenotying by flow cytometry and/or immunohistochemistry, according to 2008 WHO Classification of Hematopoietic Neoplasms. The relevant clinicopathologic features were reviewed.
Results
We identified 8 adult patients at a median age of 70 years (range: 37-84 years) with a male:female ratio of 6:2 (75%:25%) and only 1 child. Mean values of blood cell counts were as follows: WBC 5.109/L; hemoglobin 99 g/L; platelets 116.109/L. LDH was generally elevated with a mean of 962.8 U/L. At diagnosis the skin was invoved in 5/9 patients. Five patients developed leukemic presentation with 40-95% of bone marrow infiltration. Interestingly, in 4 pts (50% of adult pts) the initial presentation affected other tissues and organs such as testis, bronchial wall, stomach and periorbital soft tissues, however, only the latter one case presented with a leukemic picture. Biopsies revealed diffuse, monomorphous infiltrate of medium-sized blast cells with irregular nuclei, fine chromatin with ≥1 nucleoli, scant and agranular cytoplasm, without angioinvasion or coagulation necrosis. Immunophenotype generally demonstrated CD45+, CD4+, CD56+, CD123+. No standard therapies were applied. Patients received CHOP or HyperCVAD or AML-induction therapy. However, response rates in adult patients were low and the mean OS was 2.6 months (ranging from early deaths before any treatment could be initiated to 10 months).
Conclusion
Session topic: 4. Acute myeloid leukemia - Clinical
Keyword(s): Leukemia, Dendritic cell, CD56, CD4
Abstract: PB1693
Type: Publication Only
Background
Aims
Methods
Patients diagnosed with BPDCN at the National Hematology Hospital between 2010 and 2016 were retrieved from the database. The diagnosis was confirmed by morphology and immunophenotying by flow cytometry and/or immunohistochemistry, according to 2008 WHO Classification of Hematopoietic Neoplasms. The relevant clinicopathologic features were reviewed.
Results
We identified 8 adult patients at a median age of 70 years (range: 37-84 years) with a male:female ratio of 6:2 (75%:25%) and only 1 child. Mean values of blood cell counts were as follows: WBC 5.109/L; hemoglobin 99 g/L; platelets 116.109/L. LDH was generally elevated with a mean of 962.8 U/L. At diagnosis the skin was invoved in 5/9 patients. Five patients developed leukemic presentation with 40-95% of bone marrow infiltration. Interestingly, in 4 pts (50% of adult pts) the initial presentation affected other tissues and organs such as testis, bronchial wall, stomach and periorbital soft tissues, however, only the latter one case presented with a leukemic picture. Biopsies revealed diffuse, monomorphous infiltrate of medium-sized blast cells with irregular nuclei, fine chromatin with ≥1 nucleoli, scant and agranular cytoplasm, without angioinvasion or coagulation necrosis. Immunophenotype generally demonstrated CD45+, CD4+, CD56+, CD123+. No standard therapies were applied. Patients received CHOP or HyperCVAD or AML-induction therapy. However, response rates in adult patients were low and the mean OS was 2.6 months (ranging from early deaths before any treatment could be initiated to 10 months).
Conclusion
Session topic: 4. Acute myeloid leukemia - Clinical
Keyword(s): Leukemia, Dendritic cell, CD56, CD4