Contributions
Abstract: PB1638
Type: Publication Only
Background
Cure rates for childhood acute lymphoblastic leukemia (ALL) have approached 90% with therapeutic advances over the last several decades. Many treatment related long-term complications including impaired physical growth, neurocognitive dysfunction, emotional and occupational difficulties, cardiac abnormalities, hypertension, secondary neoplasms, decreased bone mineral density (BMD) and osteonecrosis have been observed as the number of survivors increased. Bone infiltration of leukemic cells, corticosteroids exposure, poor nutrition, low vitamin D levels, poor muscle mass, genetic predispositions contribute to the development or worsening of bone pathology during therapy that may result in osteoporosis, fracture and osteonecrosis.
Aims
In this study, we aimed to investigate whether vitamin D receptor and collagen protein gene polymorphisms, which are important in bone mineral and matrix formation, have effects on bone turnover in patients with ALL.
Methods
Results
The distribution of Fok1 and Col1A1 gene polymorphisms was similar both in the patient group and healthy control group. The frequency of gene polymorhisms in the patient group were 8% ff, 46%Ff and 46%FF for the Fok1 genotype and 62%GG, 26%GT and 12%TT for the Col1A1 genotype. Out of 50 patients, 16 (32%) patients were found to have skeletal diseases like osteopenia (16%), osteoporosis (12%) and osteonecrosis (8%). The Fok1 genotype and Col1A1 genotype polymorhisms were similar in both group of patients with or without skeletal diseases. The frequency of osteopenia was signicanly higher in the male group (p=0.049) and the frequency of osteonecrosis was signicanly higher in patients older than 10 years old (p=0.001). There was no significant association between Fok1 and Col1A1 gene polymorphisms and leukemia subtype, risk group or relapse rate.
Conclusion
It has recently become more important to prevent treatment-related complications that we see as a consequence of high cure rates in ALL. In this context we have investigated whether there is a relationship between gene polymorhisms and treatment related skeletal diseases like osteopenia, osteoporosis and osteonecrosis. We haven’t detected a significant association between Fok1 and Col1A1 gene polymorphisms and frequency of skeletal complications. Studies investigating the possible underlying genetic susceptibilites to certain complications are important not only for better management of complications but also for development of new individual patient-specific treatment modalities.
Session topic: 2. Acute lymphoblastic leukemia - Clinical
Keyword(s): Genetic polymorphism, Acute lymphoblastic leukemia, Osteoporosis, Osteonecrosis
Abstract: PB1638
Type: Publication Only
Background
Cure rates for childhood acute lymphoblastic leukemia (ALL) have approached 90% with therapeutic advances over the last several decades. Many treatment related long-term complications including impaired physical growth, neurocognitive dysfunction, emotional and occupational difficulties, cardiac abnormalities, hypertension, secondary neoplasms, decreased bone mineral density (BMD) and osteonecrosis have been observed as the number of survivors increased. Bone infiltration of leukemic cells, corticosteroids exposure, poor nutrition, low vitamin D levels, poor muscle mass, genetic predispositions contribute to the development or worsening of bone pathology during therapy that may result in osteoporosis, fracture and osteonecrosis.
Aims
In this study, we aimed to investigate whether vitamin D receptor and collagen protein gene polymorphisms, which are important in bone mineral and matrix formation, have effects on bone turnover in patients with ALL.
Methods
Results
The distribution of Fok1 and Col1A1 gene polymorphisms was similar both in the patient group and healthy control group. The frequency of gene polymorhisms in the patient group were 8% ff, 46%Ff and 46%FF for the Fok1 genotype and 62%GG, 26%GT and 12%TT for the Col1A1 genotype. Out of 50 patients, 16 (32%) patients were found to have skeletal diseases like osteopenia (16%), osteoporosis (12%) and osteonecrosis (8%). The Fok1 genotype and Col1A1 genotype polymorhisms were similar in both group of patients with or without skeletal diseases. The frequency of osteopenia was signicanly higher in the male group (p=0.049) and the frequency of osteonecrosis was signicanly higher in patients older than 10 years old (p=0.001). There was no significant association between Fok1 and Col1A1 gene polymorphisms and leukemia subtype, risk group or relapse rate.
Conclusion
It has recently become more important to prevent treatment-related complications that we see as a consequence of high cure rates in ALL. In this context we have investigated whether there is a relationship between gene polymorhisms and treatment related skeletal diseases like osteopenia, osteoporosis and osteonecrosis. We haven’t detected a significant association between Fok1 and Col1A1 gene polymorphisms and frequency of skeletal complications. Studies investigating the possible underlying genetic susceptibilites to certain complications are important not only for better management of complications but also for development of new individual patient-specific treatment modalities.
Session topic: 2. Acute lymphoblastic leukemia - Clinical
Keyword(s): Genetic polymorphism, Acute lymphoblastic leukemia, Osteoporosis, Osteonecrosis