Contributions
Abstract: P06
Type: Poster presentation
Presentation during EHA Scientific Conference on Bleeding Disorders:
On Friday, September 16, 2016 from 14:00 - 15:30
Location: Cristal + Coral
Objective
To assess the frequency of inherited bleeding disorders in women with endometriosisand to establish if there is an association between coagulation parameters and severity of endometriosis.
Design
A case-control study including women with endometriosis and age-matched controls
Setting
Conducted at the Royal Free Hospital (RFH), north London from July 2013 until July 2014
Population
Case participants were women with a surgically confirmed diagnosis of endometriosis (n=84). Control participants were staff members of the RFH matched by age and ethnicity (n=30).
Methods
All participants were interviewed to complete pain impact questionnaire (PIQ), pictorial blood assessment chart (PBAC), and grade of endometriosis (cases only).Laparoscopic revised American Society of Reproductive Medicine (rASRM) stage ofendometriosis was documented where recorded. Laboratory investigations ofhaemostasis included platelet aggregation testing, and coagulation factor levels (VIII, IX, XI, XIII, von Willebrand factor [VWF]).
Main outcome measure
Frequency of platelet aggregation defects or factor deficiency in women withendometriosis compared to controls. Correlation of factor levels with laparoscopic staging and PIQ score.
Results
Women with endometriosis had significantly more defects of platelet aggregation to one and multiple agonist compared to controls (31% vs 4%, p = 0.005 and 15% vs 4%, p < 0.05, respectively). VWF level demonstrated a significant downward trend with increasing laparoscopic stage (r = -0.35, p = 0.01). Five women with severe endometriosis had a VWF level < 50 IU dL-1.
Conclusion
Endometriosis is associated with platelet aggregation defects. This may have important implications in the treatment of endometriosis.
References
1. Rai P, Shivaji S. The role of DJ-1 in the pathogenesis of endometriosis. PLoS One. 2011;6(3):e18074.
2. Braun DP, Ding J, Dmowski WP. Peritoneal fluid-mediated enhancement of eutopic and ectopic endometrial cell proliferation is dependent on tumor necrosis factor-alpha in women with endometriosis. Fertility and sterility. 2002 Oct;78(4):727
3. Kadir RA, Economides DL, Sabin CA, Pollard D, Lee CA. Assessment of menstrual blood loss and gynaecological problems in patients with inherited bleeding disorders. Haemophilia: the official journal of the World Federation of Hemophilia. 1999 Jan;5(1):40-8.
Abstract: P06
Type: Poster presentation
Presentation during EHA Scientific Conference on Bleeding Disorders:
On Friday, September 16, 2016 from 14:00 - 15:30
Location: Cristal + Coral
Objective
To assess the frequency of inherited bleeding disorders in women with endometriosisand to establish if there is an association between coagulation parameters and severity of endometriosis.
Design
A case-control study including women with endometriosis and age-matched controls
Setting
Conducted at the Royal Free Hospital (RFH), north London from July 2013 until July 2014
Population
Case participants were women with a surgically confirmed diagnosis of endometriosis (n=84). Control participants were staff members of the RFH matched by age and ethnicity (n=30).
Methods
All participants were interviewed to complete pain impact questionnaire (PIQ), pictorial blood assessment chart (PBAC), and grade of endometriosis (cases only).Laparoscopic revised American Society of Reproductive Medicine (rASRM) stage ofendometriosis was documented where recorded. Laboratory investigations ofhaemostasis included platelet aggregation testing, and coagulation factor levels (VIII, IX, XI, XIII, von Willebrand factor [VWF]).
Main outcome measure
Frequency of platelet aggregation defects or factor deficiency in women withendometriosis compared to controls. Correlation of factor levels with laparoscopic staging and PIQ score.
Results
Women with endometriosis had significantly more defects of platelet aggregation to one and multiple agonist compared to controls (31% vs 4%, p = 0.005 and 15% vs 4%, p < 0.05, respectively). VWF level demonstrated a significant downward trend with increasing laparoscopic stage (r = -0.35, p = 0.01). Five women with severe endometriosis had a VWF level < 50 IU dL-1.
Conclusion
Endometriosis is associated with platelet aggregation defects. This may have important implications in the treatment of endometriosis.
References
1. Rai P, Shivaji S. The role of DJ-1 in the pathogenesis of endometriosis. PLoS One. 2011;6(3):e18074.
2. Braun DP, Ding J, Dmowski WP. Peritoneal fluid-mediated enhancement of eutopic and ectopic endometrial cell proliferation is dependent on tumor necrosis factor-alpha in women with endometriosis. Fertility and sterility. 2002 Oct;78(4):727
3. Kadir RA, Economides DL, Sabin CA, Pollard D, Lee CA. Assessment of menstrual blood loss and gynaecological problems in patients with inherited bleeding disorders. Haemophilia: the official journal of the World Federation of Hemophilia. 1999 Jan;5(1):40-8.