RED CELL AND HAEMOGLOBIN ABNORMALITIES ARE POTENTIAL BARRIERS TO BLOOD DONATION IN PERSONS OF SUB-SAHARAN ETHNICITY
(Abstract release date: 05/19/16)
EHA Library. Berzuini A. 06/09/16; 135385; LB2274
Dr. Alessandra Berzuini
Contributions
Contributions
Abstract
Abstract: LB2274
Type: Eposter Presentation
Background
A substantial increase of persons affected by Sickle Cell Disease (SCD) is expected in European countries, due to migratory flows from Sub-Saharan (SSA) and other endemic areas. Blood transfusion is the essential treatment for people affected by SCD but, due to an intrinsic susceptibility, at least 1/3 of them develop red blood cell (RBC) alloimmunization, which is also favoured by the peculiar antigen patterns found in SSA. For these reasons SCD patients should receive fully matched blood starting from early childhood, and the only way to reach this objective is to include in the donor pool persons of the same ethnicity, who are also at risk of having congenital red cell and haemoglobin (Hb) defects. The conditions are potentially harmful for blood recipient due to increased risk of hemolysis and/or veno-occlusive crises after transfusion.
Aims
The aim of this study was to assess the prevalence of RBC and Hb defects in an apparently healthy population of first generation foreign citizens native of SSA areas.
Methods
In March 2014 we started a 24-months program for the recruitment of foreign citizens to become blood donors in the area of Lecco, Italy. Of 450 potentially eligible persons, 175 (65 f, 110 m), gave their informed consent to undergo clinical and behavioural pre donation assessments according to the European regulation, as well as to the glucose-6-phosphate dehydrogenase (G6PDH) concentration and Hb electrophoresis.
Results
G6PDH concentration could be determined in 169 persons, allowing us to identify 55 (33%) with reduced enzyme concentration, including 25 (15%) with severe deficiency (i.e. <5 u/gHb). Despite the X-linked transmission, 8% of females had severe deficiency. Hb electrophoresis could be assessed in 173 persons. The overall prevalence of Hb variants was 32%: 28 subjects (21% f, 12% m), were carriers of HbS; 19 (11%) had beta thalassemia trait, and 8 (5%) were HbC carriers. Coexpression of G6PDH deficiency and HbS was found in 5% of subjects.
Conclusion
Despite the clinicians expectations of an increased availability of donors from SSA to provide a better matched blood supply for SSD patients, a substantial proportion of candidate donors will be carrier of RBC and/or Hb abnormalities, representing a major contraindication to blood components preparation.
Session topic: E-poster
Keyword(s): Hemoglobin variants, Transfusion
Type: Eposter Presentation
Background
A substantial increase of persons affected by Sickle Cell Disease (SCD) is expected in European countries, due to migratory flows from Sub-Saharan (SSA) and other endemic areas. Blood transfusion is the essential treatment for people affected by SCD but, due to an intrinsic susceptibility, at least 1/3 of them develop red blood cell (RBC) alloimmunization, which is also favoured by the peculiar antigen patterns found in SSA. For these reasons SCD patients should receive fully matched blood starting from early childhood, and the only way to reach this objective is to include in the donor pool persons of the same ethnicity, who are also at risk of having congenital red cell and haemoglobin (Hb) defects. The conditions are potentially harmful for blood recipient due to increased risk of hemolysis and/or veno-occlusive crises after transfusion.
Aims
The aim of this study was to assess the prevalence of RBC and Hb defects in an apparently healthy population of first generation foreign citizens native of SSA areas.
Methods
In March 2014 we started a 24-months program for the recruitment of foreign citizens to become blood donors in the area of Lecco, Italy. Of 450 potentially eligible persons, 175 (65 f, 110 m), gave their informed consent to undergo clinical and behavioural pre donation assessments according to the European regulation, as well as to the glucose-6-phosphate dehydrogenase (G6PDH) concentration and Hb electrophoresis.
Results
G6PDH concentration could be determined in 169 persons, allowing us to identify 55 (33%) with reduced enzyme concentration, including 25 (15%) with severe deficiency (i.e. <5 u/gHb). Despite the X-linked transmission, 8% of females had severe deficiency. Hb electrophoresis could be assessed in 173 persons. The overall prevalence of Hb variants was 32%: 28 subjects (21% f, 12% m), were carriers of HbS; 19 (11%) had beta thalassemia trait, and 8 (5%) were HbC carriers. Coexpression of G6PDH deficiency and HbS was found in 5% of subjects.
Conclusion
Despite the clinicians expectations of an increased availability of donors from SSA to provide a better matched blood supply for SSD patients, a substantial proportion of candidate donors will be carrier of RBC and/or Hb abnormalities, representing a major contraindication to blood components preparation.
Session topic: E-poster
Keyword(s): Hemoglobin variants, Transfusion
Abstract: LB2274
Type: Eposter Presentation
Background
A substantial increase of persons affected by Sickle Cell Disease (SCD) is expected in European countries, due to migratory flows from Sub-Saharan (SSA) and other endemic areas. Blood transfusion is the essential treatment for people affected by SCD but, due to an intrinsic susceptibility, at least 1/3 of them develop red blood cell (RBC) alloimmunization, which is also favoured by the peculiar antigen patterns found in SSA. For these reasons SCD patients should receive fully matched blood starting from early childhood, and the only way to reach this objective is to include in the donor pool persons of the same ethnicity, who are also at risk of having congenital red cell and haemoglobin (Hb) defects. The conditions are potentially harmful for blood recipient due to increased risk of hemolysis and/or veno-occlusive crises after transfusion.
Aims
The aim of this study was to assess the prevalence of RBC and Hb defects in an apparently healthy population of first generation foreign citizens native of SSA areas.
Methods
In March 2014 we started a 24-months program for the recruitment of foreign citizens to become blood donors in the area of Lecco, Italy. Of 450 potentially eligible persons, 175 (65 f, 110 m), gave their informed consent to undergo clinical and behavioural pre donation assessments according to the European regulation, as well as to the glucose-6-phosphate dehydrogenase (G6PDH) concentration and Hb electrophoresis.
Results
G6PDH concentration could be determined in 169 persons, allowing us to identify 55 (33%) with reduced enzyme concentration, including 25 (15%) with severe deficiency (i.e. <5 u/gHb). Despite the X-linked transmission, 8% of females had severe deficiency. Hb electrophoresis could be assessed in 173 persons. The overall prevalence of Hb variants was 32%: 28 subjects (21% f, 12% m), were carriers of HbS; 19 (11%) had beta thalassemia trait, and 8 (5%) were HbC carriers. Coexpression of G6PDH deficiency and HbS was found in 5% of subjects.
Conclusion
Despite the clinicians expectations of an increased availability of donors from SSA to provide a better matched blood supply for SSD patients, a substantial proportion of candidate donors will be carrier of RBC and/or Hb abnormalities, representing a major contraindication to blood components preparation.
Session topic: E-poster
Keyword(s): Hemoglobin variants, Transfusion
Type: Eposter Presentation
Background
A substantial increase of persons affected by Sickle Cell Disease (SCD) is expected in European countries, due to migratory flows from Sub-Saharan (SSA) and other endemic areas. Blood transfusion is the essential treatment for people affected by SCD but, due to an intrinsic susceptibility, at least 1/3 of them develop red blood cell (RBC) alloimmunization, which is also favoured by the peculiar antigen patterns found in SSA. For these reasons SCD patients should receive fully matched blood starting from early childhood, and the only way to reach this objective is to include in the donor pool persons of the same ethnicity, who are also at risk of having congenital red cell and haemoglobin (Hb) defects. The conditions are potentially harmful for blood recipient due to increased risk of hemolysis and/or veno-occlusive crises after transfusion.
Aims
The aim of this study was to assess the prevalence of RBC and Hb defects in an apparently healthy population of first generation foreign citizens native of SSA areas.
Methods
In March 2014 we started a 24-months program for the recruitment of foreign citizens to become blood donors in the area of Lecco, Italy. Of 450 potentially eligible persons, 175 (65 f, 110 m), gave their informed consent to undergo clinical and behavioural pre donation assessments according to the European regulation, as well as to the glucose-6-phosphate dehydrogenase (G6PDH) concentration and Hb electrophoresis.
Results
G6PDH concentration could be determined in 169 persons, allowing us to identify 55 (33%) with reduced enzyme concentration, including 25 (15%) with severe deficiency (i.e. <5 u/gHb). Despite the X-linked transmission, 8% of females had severe deficiency. Hb electrophoresis could be assessed in 173 persons. The overall prevalence of Hb variants was 32%: 28 subjects (21% f, 12% m), were carriers of HbS; 19 (11%) had beta thalassemia trait, and 8 (5%) were HbC carriers. Coexpression of G6PDH deficiency and HbS was found in 5% of subjects.
Conclusion
Despite the clinicians expectations of an increased availability of donors from SSA to provide a better matched blood supply for SSD patients, a substantial proportion of candidate donors will be carrier of RBC and/or Hb abnormalities, representing a major contraindication to blood components preparation.
Session topic: E-poster
Keyword(s): Hemoglobin variants, Transfusion
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