A PRELIMINARY DISCUSSION ON THE RELATIONSHIP BETWEEN SERUM BIOMARKERS AND AGVHD IN PATIENTS WITH ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
(Abstract release date: 05/19/16)
EHA Library. ZHANG C. 06/09/16; 135382; LB2271
Prof. Cheng ZHANG
Contributions
Contributions
Abstract
Abstract: LB2271
Type: Eposter Presentation
Background
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective means for the treatment of a variety of hematologic malignancies. Acute graft versus host disease (aGVHD) is a common complication after allo-HSCT. And it seriously affects the quality of life and survival rate of patients and is also the main cause of non relapse mortality in allo-HSCT patients. The diagnosis of aGVHD mainly depends on the clinical manifestations and pathological examination of the damaged target organs. But its clinical symptoms are changeable and lack of specificity, the pathological examination often in clinical diagnosis and treatment because of various reasons can not be carried out.
Aims
To explore the relationship between serum biomarkers and aGVHD in allo-HSCT patients at different time points, and to provide theoretical basis for early intervention and prognosis evaluation of aGVHD.
Methods
Collection the serum samples of patients with allo-HSCT in November 2014 to November 2015 in the Department of Hematology, Xinqiao Hospital, Third Military Medical University . 10 patients with aGVHD were selected as the case group, and 10 patients without aGVHD were randomly selected as the control group. Protein chip technology was used to detect the content of IL-1β、IL-7、IL-8、ST2、vWF in plasma of the two groups patients in 7 days before transplantion and 7 days、14 days、28 days、56 days、100 days after transplantation.
Results
Compared aGVHD group and non-aGVHD group, 7 days and 56 days after transplantion, the level of ST2 in serum were significantly increased (P<0.05); 28 days、56 days and 100 days after transplantion, the level of IL-7 in plasma were significantly increased (P<0.05); 56 days after transplantion, the level of IL-1β in plasma were significantly increased (P<0.05); Serum IL-8 and vWF were not significantly different between two groups in every time points.
Conclusion
The content of IL-1β、IL-7、ST2 in serum of patients with aGVHD after transplantation is higher than that of patients who were not aGVHD, and they can be used as the auxiliary diagnosis index of aGVHD and is helpful to early diagnosis and intervention of aGVHD. Monitoring of serum biomarkers for aGVHD immune targeted therapy provides a new direction.
Session topic: E-poster
Keyword(s): Acute graft-versus-host disease, Allogeneic hematopoietic stem cell transplant
Type: Eposter Presentation
Background
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective means for the treatment of a variety of hematologic malignancies. Acute graft versus host disease (aGVHD) is a common complication after allo-HSCT. And it seriously affects the quality of life and survival rate of patients and is also the main cause of non relapse mortality in allo-HSCT patients. The diagnosis of aGVHD mainly depends on the clinical manifestations and pathological examination of the damaged target organs. But its clinical symptoms are changeable and lack of specificity, the pathological examination often in clinical diagnosis and treatment because of various reasons can not be carried out.
Aims
To explore the relationship between serum biomarkers and aGVHD in allo-HSCT patients at different time points, and to provide theoretical basis for early intervention and prognosis evaluation of aGVHD.
Methods
Collection the serum samples of patients with allo-HSCT in November 2014 to November 2015 in the Department of Hematology, Xinqiao Hospital, Third Military Medical University . 10 patients with aGVHD were selected as the case group, and 10 patients without aGVHD were randomly selected as the control group. Protein chip technology was used to detect the content of IL-1β、IL-7、IL-8、ST2、vWF in plasma of the two groups patients in 7 days before transplantion and 7 days、14 days、28 days、56 days、100 days after transplantation.
Results
Compared aGVHD group and non-aGVHD group, 7 days and 56 days after transplantion, the level of ST2 in serum were significantly increased (P<0.05); 28 days、56 days and 100 days after transplantion, the level of IL-7 in plasma were significantly increased (P<0.05); 56 days after transplantion, the level of IL-1β in plasma were significantly increased (P<0.05); Serum IL-8 and vWF were not significantly different between two groups in every time points.
Conclusion
The content of IL-1β、IL-7、ST2 in serum of patients with aGVHD after transplantation is higher than that of patients who were not aGVHD, and they can be used as the auxiliary diagnosis index of aGVHD and is helpful to early diagnosis and intervention of aGVHD. Monitoring of serum biomarkers for aGVHD immune targeted therapy provides a new direction.
Session topic: E-poster
Keyword(s): Acute graft-versus-host disease, Allogeneic hematopoietic stem cell transplant
Abstract: LB2271
Type: Eposter Presentation
Background
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective means for the treatment of a variety of hematologic malignancies. Acute graft versus host disease (aGVHD) is a common complication after allo-HSCT. And it seriously affects the quality of life and survival rate of patients and is also the main cause of non relapse mortality in allo-HSCT patients. The diagnosis of aGVHD mainly depends on the clinical manifestations and pathological examination of the damaged target organs. But its clinical symptoms are changeable and lack of specificity, the pathological examination often in clinical diagnosis and treatment because of various reasons can not be carried out.
Aims
To explore the relationship between serum biomarkers and aGVHD in allo-HSCT patients at different time points, and to provide theoretical basis for early intervention and prognosis evaluation of aGVHD.
Methods
Collection the serum samples of patients with allo-HSCT in November 2014 to November 2015 in the Department of Hematology, Xinqiao Hospital, Third Military Medical University . 10 patients with aGVHD were selected as the case group, and 10 patients without aGVHD were randomly selected as the control group. Protein chip technology was used to detect the content of IL-1β、IL-7、IL-8、ST2、vWF in plasma of the two groups patients in 7 days before transplantion and 7 days、14 days、28 days、56 days、100 days after transplantation.
Results
Compared aGVHD group and non-aGVHD group, 7 days and 56 days after transplantion, the level of ST2 in serum were significantly increased (P<0.05); 28 days、56 days and 100 days after transplantion, the level of IL-7 in plasma were significantly increased (P<0.05); 56 days after transplantion, the level of IL-1β in plasma were significantly increased (P<0.05); Serum IL-8 and vWF were not significantly different between two groups in every time points.
Conclusion
The content of IL-1β、IL-7、ST2 in serum of patients with aGVHD after transplantation is higher than that of patients who were not aGVHD, and they can be used as the auxiliary diagnosis index of aGVHD and is helpful to early diagnosis and intervention of aGVHD. Monitoring of serum biomarkers for aGVHD immune targeted therapy provides a new direction.
Session topic: E-poster
Keyword(s): Acute graft-versus-host disease, Allogeneic hematopoietic stem cell transplant
Type: Eposter Presentation
Background
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective means for the treatment of a variety of hematologic malignancies. Acute graft versus host disease (aGVHD) is a common complication after allo-HSCT. And it seriously affects the quality of life and survival rate of patients and is also the main cause of non relapse mortality in allo-HSCT patients. The diagnosis of aGVHD mainly depends on the clinical manifestations and pathological examination of the damaged target organs. But its clinical symptoms are changeable and lack of specificity, the pathological examination often in clinical diagnosis and treatment because of various reasons can not be carried out.
Aims
To explore the relationship between serum biomarkers and aGVHD in allo-HSCT patients at different time points, and to provide theoretical basis for early intervention and prognosis evaluation of aGVHD.
Methods
Collection the serum samples of patients with allo-HSCT in November 2014 to November 2015 in the Department of Hematology, Xinqiao Hospital, Third Military Medical University . 10 patients with aGVHD were selected as the case group, and 10 patients without aGVHD were randomly selected as the control group. Protein chip technology was used to detect the content of IL-1β、IL-7、IL-8、ST2、vWF in plasma of the two groups patients in 7 days before transplantion and 7 days、14 days、28 days、56 days、100 days after transplantation.
Results
Compared aGVHD group and non-aGVHD group, 7 days and 56 days after transplantion, the level of ST2 in serum were significantly increased (P<0.05); 28 days、56 days and 100 days after transplantion, the level of IL-7 in plasma were significantly increased (P<0.05); 56 days after transplantion, the level of IL-1β in plasma were significantly increased (P<0.05); Serum IL-8 and vWF were not significantly different between two groups in every time points.
Conclusion
The content of IL-1β、IL-7、ST2 in serum of patients with aGVHD after transplantation is higher than that of patients who were not aGVHD, and they can be used as the auxiliary diagnosis index of aGVHD and is helpful to early diagnosis and intervention of aGVHD. Monitoring of serum biomarkers for aGVHD immune targeted therapy provides a new direction.
Session topic: E-poster
Keyword(s): Acute graft-versus-host disease, Allogeneic hematopoietic stem cell transplant
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