OUTCOME OF PATIENTS WITH HIGH RISK ACUTE LYMPHOBLASTIC LEUKEMIA IN HAPLOID-MATCHED VS SIBLING-MATCHED ALLOGENEIC STEM CELL TRANSPLANTATION
(Abstract release date: 05/19/16)
EHA Library. ZHANG C. 06/09/16; 135351; LB2240
Prof. Cheng ZHANG
Contributions
Contributions
Abstract
Abstract: LB2240
Type: Eposter Presentation
Background
The efficacy of allogeneic stem cell transplantation in patients with high risk acute lymphoblastic leukemia ( ALL) is unclea, and the relevant prognostic factors are not well-known.
Aims
To explore the efficacy of allogeneic stem cell transplantation in patients with high risk acute lymphoblastic leukemia ( ALL) and investigate its relevant prognostic factors
Methods
A total of 69 patients with ALL who were treated with allo-HSCT in our hospital from July 2007 to August 2013,all patients were followed up more than two years.They were divided into haploid-matched (haploidentical allogeneic stem cell transplantation) group (n=42) and sibling-matched(HLA sibling-matched allogeneic stem cell transplantation) group ( n= 27).Clinical characteristics of two groups were retrospectively analyzed.Survival date were analyzed by the Kaplan?Meier method and the prognostic factors were analyzed with the COX regression model.
Results
2 years over-all survival(OS) is 63.4% in haploid-matched group,53.9% in sibling-matched group, difference was not statistically significant(P=0.197);and 2 year LFS(leukemia?free survival) is 59.4% and 53.7% in haploid-matched group and sibling-matched group respectively,difference was not statistically significant(P=0.17).2 years RR(relapse rate) of sibling-matched group(39.5%) is higher than that of haploid-matched group(19.5%)(P=0.014).In hematopoietic reconstruction,Neutrophils reconstruction of the haploid-matched group later than sibling-matched group(P=0.002),and platelet reconstruction in two group is similar(P=0.072). Grade I-II aGVHD( acute graft-versus-host disease)in haploid-matched group is higher than sibling-matched group(P=0.008),then grade III-IV aGVHD and chronic GVHD are similar(P=0.726,P=0.81 respectively) in two group. We collected the early(six months) infection after HSCT, infection rate of haploid-matched group is higher than sibling-matched group(P=0.02).2 year NRM(non-relapse mortality) rate of sibling-matched group is 11.1%, NRM rate of haploid-matched group is 26.2%,the difference was not statistically significant(P=0.519). The Cox regression analysis showed that disease status before transplant ( not CR1) were main risk factors affecting LFS of patients(P=0.001), relative risks is 7.581.limtited GVHD (P=0.013)and shorter time from first diagnosed to transplantation (P=0.012)is protective factors,relative risks is 0.178 and 0.688 respectively.
Conclusion
In high-risk patients with ALL,haploid-matched and sibling-matched HSCT are similar in total outcome. haploid-matched donor can be suitable source of allogeneic stem cell transplantation.
Session topic: E-poster
Keyword(s): Acute lymphoblastic leukemia, Allo-SCT, Haploidentical stem cell transplantation
Type: Eposter Presentation
Background
The efficacy of allogeneic stem cell transplantation in patients with high risk acute lymphoblastic leukemia ( ALL) is unclea, and the relevant prognostic factors are not well-known.
Aims
To explore the efficacy of allogeneic stem cell transplantation in patients with high risk acute lymphoblastic leukemia ( ALL) and investigate its relevant prognostic factors
Methods
A total of 69 patients with ALL who were treated with allo-HSCT in our hospital from July 2007 to August 2013,all patients were followed up more than two years.They were divided into haploid-matched (haploidentical allogeneic stem cell transplantation) group (n=42) and sibling-matched(HLA sibling-matched allogeneic stem cell transplantation) group ( n= 27).Clinical characteristics of two groups were retrospectively analyzed.Survival date were analyzed by the Kaplan?Meier method and the prognostic factors were analyzed with the COX regression model.
Results
2 years over-all survival(OS) is 63.4% in haploid-matched group,53.9% in sibling-matched group, difference was not statistically significant(P=0.197);and 2 year LFS(leukemia?free survival) is 59.4% and 53.7% in haploid-matched group and sibling-matched group respectively,difference was not statistically significant(P=0.17).2 years RR(relapse rate) of sibling-matched group(39.5%) is higher than that of haploid-matched group(19.5%)(P=0.014).In hematopoietic reconstruction,Neutrophils reconstruction of the haploid-matched group later than sibling-matched group(P=0.002),and platelet reconstruction in two group is similar(P=0.072). Grade I-II aGVHD( acute graft-versus-host disease)in haploid-matched group is higher than sibling-matched group(P=0.008),then grade III-IV aGVHD and chronic GVHD are similar(P=0.726,P=0.81 respectively) in two group. We collected the early(six months) infection after HSCT, infection rate of haploid-matched group is higher than sibling-matched group(P=0.02).2 year NRM(non-relapse mortality) rate of sibling-matched group is 11.1%, NRM rate of haploid-matched group is 26.2%,the difference was not statistically significant(P=0.519). The Cox regression analysis showed that disease status before transplant ( not CR1) were main risk factors affecting LFS of patients(P=0.001), relative risks is 7.581.limtited GVHD (P=0.013)and shorter time from first diagnosed to transplantation (P=0.012)is protective factors,relative risks is 0.178 and 0.688 respectively.
Conclusion
In high-risk patients with ALL,haploid-matched and sibling-matched HSCT are similar in total outcome. haploid-matched donor can be suitable source of allogeneic stem cell transplantation.
Session topic: E-poster
Keyword(s): Acute lymphoblastic leukemia, Allo-SCT, Haploidentical stem cell transplantation
Abstract: LB2240
Type: Eposter Presentation
Background
The efficacy of allogeneic stem cell transplantation in patients with high risk acute lymphoblastic leukemia ( ALL) is unclea, and the relevant prognostic factors are not well-known.
Aims
To explore the efficacy of allogeneic stem cell transplantation in patients with high risk acute lymphoblastic leukemia ( ALL) and investigate its relevant prognostic factors
Methods
A total of 69 patients with ALL who were treated with allo-HSCT in our hospital from July 2007 to August 2013,all patients were followed up more than two years.They were divided into haploid-matched (haploidentical allogeneic stem cell transplantation) group (n=42) and sibling-matched(HLA sibling-matched allogeneic stem cell transplantation) group ( n= 27).Clinical characteristics of two groups were retrospectively analyzed.Survival date were analyzed by the Kaplan?Meier method and the prognostic factors were analyzed with the COX regression model.
Results
2 years over-all survival(OS) is 63.4% in haploid-matched group,53.9% in sibling-matched group, difference was not statistically significant(P=0.197);and 2 year LFS(leukemia?free survival) is 59.4% and 53.7% in haploid-matched group and sibling-matched group respectively,difference was not statistically significant(P=0.17).2 years RR(relapse rate) of sibling-matched group(39.5%) is higher than that of haploid-matched group(19.5%)(P=0.014).In hematopoietic reconstruction,Neutrophils reconstruction of the haploid-matched group later than sibling-matched group(P=0.002),and platelet reconstruction in two group is similar(P=0.072). Grade I-II aGVHD( acute graft-versus-host disease)in haploid-matched group is higher than sibling-matched group(P=0.008),then grade III-IV aGVHD and chronic GVHD are similar(P=0.726,P=0.81 respectively) in two group. We collected the early(six months) infection after HSCT, infection rate of haploid-matched group is higher than sibling-matched group(P=0.02).2 year NRM(non-relapse mortality) rate of sibling-matched group is 11.1%, NRM rate of haploid-matched group is 26.2%,the difference was not statistically significant(P=0.519). The Cox regression analysis showed that disease status before transplant ( not CR1) were main risk factors affecting LFS of patients(P=0.001), relative risks is 7.581.limtited GVHD (P=0.013)and shorter time from first diagnosed to transplantation (P=0.012)is protective factors,relative risks is 0.178 and 0.688 respectively.
Conclusion
In high-risk patients with ALL,haploid-matched and sibling-matched HSCT are similar in total outcome. haploid-matched donor can be suitable source of allogeneic stem cell transplantation.
Session topic: E-poster
Keyword(s): Acute lymphoblastic leukemia, Allo-SCT, Haploidentical stem cell transplantation
Type: Eposter Presentation
Background
The efficacy of allogeneic stem cell transplantation in patients with high risk acute lymphoblastic leukemia ( ALL) is unclea, and the relevant prognostic factors are not well-known.
Aims
To explore the efficacy of allogeneic stem cell transplantation in patients with high risk acute lymphoblastic leukemia ( ALL) and investigate its relevant prognostic factors
Methods
A total of 69 patients with ALL who were treated with allo-HSCT in our hospital from July 2007 to August 2013,all patients were followed up more than two years.They were divided into haploid-matched (haploidentical allogeneic stem cell transplantation) group (n=42) and sibling-matched(HLA sibling-matched allogeneic stem cell transplantation) group ( n= 27).Clinical characteristics of two groups were retrospectively analyzed.Survival date were analyzed by the Kaplan?Meier method and the prognostic factors were analyzed with the COX regression model.
Results
2 years over-all survival(OS) is 63.4% in haploid-matched group,53.9% in sibling-matched group, difference was not statistically significant(P=0.197);and 2 year LFS(leukemia?free survival) is 59.4% and 53.7% in haploid-matched group and sibling-matched group respectively,difference was not statistically significant(P=0.17).2 years RR(relapse rate) of sibling-matched group(39.5%) is higher than that of haploid-matched group(19.5%)(P=0.014).In hematopoietic reconstruction,Neutrophils reconstruction of the haploid-matched group later than sibling-matched group(P=0.002),and platelet reconstruction in two group is similar(P=0.072). Grade I-II aGVHD( acute graft-versus-host disease)in haploid-matched group is higher than sibling-matched group(P=0.008),then grade III-IV aGVHD and chronic GVHD are similar(P=0.726,P=0.81 respectively) in two group. We collected the early(six months) infection after HSCT, infection rate of haploid-matched group is higher than sibling-matched group(P=0.02).2 year NRM(non-relapse mortality) rate of sibling-matched group is 11.1%, NRM rate of haploid-matched group is 26.2%,the difference was not statistically significant(P=0.519). The Cox regression analysis showed that disease status before transplant ( not CR1) were main risk factors affecting LFS of patients(P=0.001), relative risks is 7.581.limtited GVHD (P=0.013)and shorter time from first diagnosed to transplantation (P=0.012)is protective factors,relative risks is 0.178 and 0.688 respectively.
Conclusion
In high-risk patients with ALL,haploid-matched and sibling-matched HSCT are similar in total outcome. haploid-matched donor can be suitable source of allogeneic stem cell transplantation.
Session topic: E-poster
Keyword(s): Acute lymphoblastic leukemia, Allo-SCT, Haploidentical stem cell transplantation
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