DONOR AND RECIPIENT TOLL-LIKE RECEPTOR 1 VARIATIONS COMPARABLY PREDICT TRANSPLANT-RELATED MORTALITY AFTER UNRELATED BONE MARROW TRANSPLANTATION.
(Abstract release date: 05/19/16)
EHA Library. Uchino K. 06/12/16; 135316; S822
Dr. Kaori Uchino
Contributions
Contributions
Abstract
Abstract: S822
Type: Oral Presentation
Presentation during EHA21: On Sunday, June 12, 2016 from 09:00 - 09:15
Location: Hall C15
Background
Toll-like receptor 1 (TLR1), the most ubiquitous among the TLR family, plays an essential role in the innate immunity system through initiating the production of inflammatory cytokines. Its genetic variant (rs5743551, -7202 A>G), which resides in the promoter region, has been reported to be associated with susceptibility to various infectious diseases and the mortality and morbidity.
Aims
To investigate the impact of TLR1 variation on transplant outcomes of bone marrow transplantation (BMT).
Methods
TLR1 genotyping was performed on 333 patients who underwent unrelated HLA-matched BMT for hematologic malignancies through the Japan Marrow Donor Program between May 2006 and April 2009 and their donors, and its association with the transplant outcomes was retrospectively examined.
Results
The genotype frequencies of A/A, A/G, and G/G were 10%, 39% and 50% in the recipients and 11%, 36% and 51% in the donors (P=0.82), respectively. The A/A genotype vs. A/G or G/G genotype both in the donors (37% vs. 18%, respectively; P=0.0042) and the recipients (39% vs. 17%, respectively; P=0.021) was associated with a significantly higher 3-year transplant-related mortality (TRM). The A/A genotype in the donors (hazard ratio [HR], 3.4; 95% confidence interval [CI], 1.6-7.2; P=0.0017) and the recipients (HR, 2.6; 95% CI, 1.3-5.4; P=0.0093 ) remained statistically significant in the multivariate analysis for 3-year TRM.
Conclusion
These results suggest an association of the donor and recipient TLR1 A/A genotype with increased TRM after unrelated BMT. An analysis of the TLR1 genotype could therefore be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent TRM after hematopoietic stem cell transplantation.
Session topic: Stem cell transplantation - Clinical 2
Keyword(s): SNP
Type: Oral Presentation
Presentation during EHA21: On Sunday, June 12, 2016 from 09:00 - 09:15
Location: Hall C15
Background
Toll-like receptor 1 (TLR1), the most ubiquitous among the TLR family, plays an essential role in the innate immunity system through initiating the production of inflammatory cytokines. Its genetic variant (rs5743551, -7202 A>G), which resides in the promoter region, has been reported to be associated with susceptibility to various infectious diseases and the mortality and morbidity.
Aims
To investigate the impact of TLR1 variation on transplant outcomes of bone marrow transplantation (BMT).
Methods
TLR1 genotyping was performed on 333 patients who underwent unrelated HLA-matched BMT for hematologic malignancies through the Japan Marrow Donor Program between May 2006 and April 2009 and their donors, and its association with the transplant outcomes was retrospectively examined.
Results
The genotype frequencies of A/A, A/G, and G/G were 10%, 39% and 50% in the recipients and 11%, 36% and 51% in the donors (P=0.82), respectively. The A/A genotype vs. A/G or G/G genotype both in the donors (37% vs. 18%, respectively; P=0.0042) and the recipients (39% vs. 17%, respectively; P=0.021) was associated with a significantly higher 3-year transplant-related mortality (TRM). The A/A genotype in the donors (hazard ratio [HR], 3.4; 95% confidence interval [CI], 1.6-7.2; P=0.0017) and the recipients (HR, 2.6; 95% CI, 1.3-5.4; P=0.0093 ) remained statistically significant in the multivariate analysis for 3-year TRM.
Conclusion
These results suggest an association of the donor and recipient TLR1 A/A genotype with increased TRM after unrelated BMT. An analysis of the TLR1 genotype could therefore be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent TRM after hematopoietic stem cell transplantation.
Session topic: Stem cell transplantation - Clinical 2
Keyword(s): SNP
Abstract: S822
Type: Oral Presentation
Presentation during EHA21: On Sunday, June 12, 2016 from 09:00 - 09:15
Location: Hall C15
Background
Toll-like receptor 1 (TLR1), the most ubiquitous among the TLR family, plays an essential role in the innate immunity system through initiating the production of inflammatory cytokines. Its genetic variant (rs5743551, -7202 A>G), which resides in the promoter region, has been reported to be associated with susceptibility to various infectious diseases and the mortality and morbidity.
Aims
To investigate the impact of TLR1 variation on transplant outcomes of bone marrow transplantation (BMT).
Methods
TLR1 genotyping was performed on 333 patients who underwent unrelated HLA-matched BMT for hematologic malignancies through the Japan Marrow Donor Program between May 2006 and April 2009 and their donors, and its association with the transplant outcomes was retrospectively examined.
Results
The genotype frequencies of A/A, A/G, and G/G were 10%, 39% and 50% in the recipients and 11%, 36% and 51% in the donors (P=0.82), respectively. The A/A genotype vs. A/G or G/G genotype both in the donors (37% vs. 18%, respectively; P=0.0042) and the recipients (39% vs. 17%, respectively; P=0.021) was associated with a significantly higher 3-year transplant-related mortality (TRM). The A/A genotype in the donors (hazard ratio [HR], 3.4; 95% confidence interval [CI], 1.6-7.2; P=0.0017) and the recipients (HR, 2.6; 95% CI, 1.3-5.4; P=0.0093 ) remained statistically significant in the multivariate analysis for 3-year TRM.
Conclusion
These results suggest an association of the donor and recipient TLR1 A/A genotype with increased TRM after unrelated BMT. An analysis of the TLR1 genotype could therefore be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent TRM after hematopoietic stem cell transplantation.
Session topic: Stem cell transplantation - Clinical 2
Keyword(s): SNP
Type: Oral Presentation
Presentation during EHA21: On Sunday, June 12, 2016 from 09:00 - 09:15
Location: Hall C15
Background
Toll-like receptor 1 (TLR1), the most ubiquitous among the TLR family, plays an essential role in the innate immunity system through initiating the production of inflammatory cytokines. Its genetic variant (rs5743551, -7202 A>G), which resides in the promoter region, has been reported to be associated with susceptibility to various infectious diseases and the mortality and morbidity.
Aims
To investigate the impact of TLR1 variation on transplant outcomes of bone marrow transplantation (BMT).
Methods
TLR1 genotyping was performed on 333 patients who underwent unrelated HLA-matched BMT for hematologic malignancies through the Japan Marrow Donor Program between May 2006 and April 2009 and their donors, and its association with the transplant outcomes was retrospectively examined.
Results
The genotype frequencies of A/A, A/G, and G/G were 10%, 39% and 50% in the recipients and 11%, 36% and 51% in the donors (P=0.82), respectively. The A/A genotype vs. A/G or G/G genotype both in the donors (37% vs. 18%, respectively; P=0.0042) and the recipients (39% vs. 17%, respectively; P=0.021) was associated with a significantly higher 3-year transplant-related mortality (TRM). The A/A genotype in the donors (hazard ratio [HR], 3.4; 95% confidence interval [CI], 1.6-7.2; P=0.0017) and the recipients (HR, 2.6; 95% CI, 1.3-5.4; P=0.0093 ) remained statistically significant in the multivariate analysis for 3-year TRM.
Conclusion
These results suggest an association of the donor and recipient TLR1 A/A genotype with increased TRM after unrelated BMT. An analysis of the TLR1 genotype could therefore be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent TRM after hematopoietic stem cell transplantation.
Session topic: Stem cell transplantation - Clinical 2
Keyword(s): SNP
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