RED CELL PHENOTYPING AMONG MULTITRANSFUSED EGYPTIAN THALASSEMIC PATIENTS
(Abstract release date: 05/19/16)
EHA Library. Sarhan M. 06/09/16; 135131; PB2231
Prof. Mohamed Sarhan
Contributions
Contributions
Abstract
Abstract: PB2231
Type: Publication Only
Background
Thalassemia is an inherited hemolytic disorder caused by partial or complete deficiency of α or β-globin chain synthesis. Regular transfusions are essential for patients with thalassemia to maintain growth and development during childhood and to sustain good quality of life during adulthood. The development of hemolytic alloantibodies and red blood cell (RBC) autoantibodies complicates transfusion therapy in patients with thalassemia.
Aims
of this research is to determine the prevalence of red blood cells antigens among multitransfused thalassemic patients attending Mansoura University Children Hospital, Mansoura, Egypt and a sample of blood donors, as an approach for prevention of alloimmunization.
Methods
The present study comprised 70 mulitransfused thalassemic patients. They were 38 males and 32 females and in addition 65 adult male donors. All were subjected to Laboratory tests for blood group antigens (ABO), and (Rh system, Kell system), using ID-cards, Also a CBC was done.
Results
1) Blood group O is the most prevalent blood group in our patients but B group is the most prevalent in our donors.
2) Kell negative group is prevalent in the patients compared to the donors.
3) There is significant difference between the patients and the donors in Rosenfield : (1,2,3,4,5) and (1-2-3,4,5),More prevalent in the donors, But Rh (1,2-3-4,5) is prevalent in the patients versus the donors.
4) There is significant increase in (c), (E) and marginal increase of (k) antigens in donors versus the patients.
5) Patients below five years old showed significant increase of negative kell group and Rosenfield Rh (1,2-3-4,5).
6) No relation between sex and blood group phenotypes of the patients.
7) Significant increase of kell negative group and Rosenfield Rh (1, 2-3-4,5) in patients who were younger in age of first transfusion and who received frequent transfusions .
8) High incidence of pallor in patients with blood group O. Also patients with Rosenfield Rh (1,2-3-4,5).
9) Splenectomizd patients had significantly higher incidence of negative kell group and Rosenfield Rh (1,2-3-4,5).
Conclusion
From the present study, in order to minimize the hazards of blood transfusion, especially the immunological reactions the following could be done: 1) Pre transfusion matching of blood for ABO and Rh D antigens is important as a routine work, which helps in determining the true blood groups and it assists in the identification of suspected alloantibodies and selection of antigen-negative RBCs for transfusion. 2) Extended phenotype matching of blood for Rh (other than D) and Kell have been proposed as effective method which could reduce morbidity in thalassemic patients.
Session topic: E-poster
Keyword(s): Phenotype, Red blood cell, Thalassemia
Type: Publication Only
Background
Thalassemia is an inherited hemolytic disorder caused by partial or complete deficiency of α or β-globin chain synthesis. Regular transfusions are essential for patients with thalassemia to maintain growth and development during childhood and to sustain good quality of life during adulthood. The development of hemolytic alloantibodies and red blood cell (RBC) autoantibodies complicates transfusion therapy in patients with thalassemia.
Aims
of this research is to determine the prevalence of red blood cells antigens among multitransfused thalassemic patients attending Mansoura University Children Hospital, Mansoura, Egypt and a sample of blood donors, as an approach for prevention of alloimmunization.
Methods
The present study comprised 70 mulitransfused thalassemic patients. They were 38 males and 32 females and in addition 65 adult male donors. All were subjected to Laboratory tests for blood group antigens (ABO), and (Rh system, Kell system), using ID-cards, Also a CBC was done.
Results
1) Blood group O is the most prevalent blood group in our patients but B group is the most prevalent in our donors.
2) Kell negative group is prevalent in the patients compared to the donors.
3) There is significant difference between the patients and the donors in Rosenfield : (1,2,3,4,5) and (1-2-3,4,5),More prevalent in the donors, But Rh (1,2-3-4,5) is prevalent in the patients versus the donors.
4) There is significant increase in (c), (E) and marginal increase of (k) antigens in donors versus the patients.
5) Patients below five years old showed significant increase of negative kell group and Rosenfield Rh (1,2-3-4,5).
6) No relation between sex and blood group phenotypes of the patients.
7) Significant increase of kell negative group and Rosenfield Rh (1, 2-3-4,5) in patients who were younger in age of first transfusion and who received frequent transfusions .
8) High incidence of pallor in patients with blood group O. Also patients with Rosenfield Rh (1,2-3-4,5).
9) Splenectomizd patients had significantly higher incidence of negative kell group and Rosenfield Rh (1,2-3-4,5).
Conclusion
From the present study, in order to minimize the hazards of blood transfusion, especially the immunological reactions the following could be done: 1) Pre transfusion matching of blood for ABO and Rh D antigens is important as a routine work, which helps in determining the true blood groups and it assists in the identification of suspected alloantibodies and selection of antigen-negative RBCs for transfusion. 2) Extended phenotype matching of blood for Rh (other than D) and Kell have been proposed as effective method which could reduce morbidity in thalassemic patients.
Session topic: E-poster
Keyword(s): Phenotype, Red blood cell, Thalassemia
Abstract: PB2231
Type: Publication Only
Background
Thalassemia is an inherited hemolytic disorder caused by partial or complete deficiency of α or β-globin chain synthesis. Regular transfusions are essential for patients with thalassemia to maintain growth and development during childhood and to sustain good quality of life during adulthood. The development of hemolytic alloantibodies and red blood cell (RBC) autoantibodies complicates transfusion therapy in patients with thalassemia.
Aims
of this research is to determine the prevalence of red blood cells antigens among multitransfused thalassemic patients attending Mansoura University Children Hospital, Mansoura, Egypt and a sample of blood donors, as an approach for prevention of alloimmunization.
Methods
The present study comprised 70 mulitransfused thalassemic patients. They were 38 males and 32 females and in addition 65 adult male donors. All were subjected to Laboratory tests for blood group antigens (ABO), and (Rh system, Kell system), using ID-cards, Also a CBC was done.
Results
1) Blood group O is the most prevalent blood group in our patients but B group is the most prevalent in our donors.
2) Kell negative group is prevalent in the patients compared to the donors.
3) There is significant difference between the patients and the donors in Rosenfield : (1,2,3,4,5) and (1-2-3,4,5),More prevalent in the donors, But Rh (1,2-3-4,5) is prevalent in the patients versus the donors.
4) There is significant increase in (c), (E) and marginal increase of (k) antigens in donors versus the patients.
5) Patients below five years old showed significant increase of negative kell group and Rosenfield Rh (1,2-3-4,5).
6) No relation between sex and blood group phenotypes of the patients.
7) Significant increase of kell negative group and Rosenfield Rh (1, 2-3-4,5) in patients who were younger in age of first transfusion and who received frequent transfusions .
8) High incidence of pallor in patients with blood group O. Also patients with Rosenfield Rh (1,2-3-4,5).
9) Splenectomizd patients had significantly higher incidence of negative kell group and Rosenfield Rh (1,2-3-4,5).
Conclusion
From the present study, in order to minimize the hazards of blood transfusion, especially the immunological reactions the following could be done: 1) Pre transfusion matching of blood for ABO and Rh D antigens is important as a routine work, which helps in determining the true blood groups and it assists in the identification of suspected alloantibodies and selection of antigen-negative RBCs for transfusion. 2) Extended phenotype matching of blood for Rh (other than D) and Kell have been proposed as effective method which could reduce morbidity in thalassemic patients.
Session topic: E-poster
Keyword(s): Phenotype, Red blood cell, Thalassemia
Type: Publication Only
Background
Thalassemia is an inherited hemolytic disorder caused by partial or complete deficiency of α or β-globin chain synthesis. Regular transfusions are essential for patients with thalassemia to maintain growth and development during childhood and to sustain good quality of life during adulthood. The development of hemolytic alloantibodies and red blood cell (RBC) autoantibodies complicates transfusion therapy in patients with thalassemia.
Aims
of this research is to determine the prevalence of red blood cells antigens among multitransfused thalassemic patients attending Mansoura University Children Hospital, Mansoura, Egypt and a sample of blood donors, as an approach for prevention of alloimmunization.
Methods
The present study comprised 70 mulitransfused thalassemic patients. They were 38 males and 32 females and in addition 65 adult male donors. All were subjected to Laboratory tests for blood group antigens (ABO), and (Rh system, Kell system), using ID-cards, Also a CBC was done.
Results
1) Blood group O is the most prevalent blood group in our patients but B group is the most prevalent in our donors.
2) Kell negative group is prevalent in the patients compared to the donors.
3) There is significant difference between the patients and the donors in Rosenfield : (1,2,3,4,5) and (1-2-3,4,5),More prevalent in the donors, But Rh (1,2-3-4,5) is prevalent in the patients versus the donors.
4) There is significant increase in (c), (E) and marginal increase of (k) antigens in donors versus the patients.
5) Patients below five years old showed significant increase of negative kell group and Rosenfield Rh (1,2-3-4,5).
6) No relation between sex and blood group phenotypes of the patients.
7) Significant increase of kell negative group and Rosenfield Rh (1, 2-3-4,5) in patients who were younger in age of first transfusion and who received frequent transfusions .
8) High incidence of pallor in patients with blood group O. Also patients with Rosenfield Rh (1,2-3-4,5).
9) Splenectomizd patients had significantly higher incidence of negative kell group and Rosenfield Rh (1,2-3-4,5).
Conclusion
From the present study, in order to minimize the hazards of blood transfusion, especially the immunological reactions the following could be done: 1) Pre transfusion matching of blood for ABO and Rh D antigens is important as a routine work, which helps in determining the true blood groups and it assists in the identification of suspected alloantibodies and selection of antigen-negative RBCs for transfusion. 2) Extended phenotype matching of blood for Rh (other than D) and Kell have been proposed as effective method which could reduce morbidity in thalassemic patients.
Session topic: E-poster
Keyword(s): Phenotype, Red blood cell, Thalassemia
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