ARTERIAL HYPERTENSION IN LONG-TERM SURVIVORS AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
(Abstract release date: 05/19/16)
EHA Library. Arranto C. 06/09/16; 135080; PB2180
Dr. Christian Arranto
Contributions
Contributions
Abstract
Abstract: PB2180
Type: Publication Only
Background
Improvement of transplantation techniques and supportive care lead to an increasing number of long-term survivors after allogeneic hematopoietic stem cell transplantation (HSCT). Recipients of allogeneic HSCT have a higher prevalence of cardiovascular risk factors.
Aims
To determine the prevalence of ambulatory hypertension in patients after HSCT.
Methods
Patients ≥1 year after allogeneic HSCT were included during their annual hematological check at University Hospital Basel, Switzerland. Blood pressure (BP) was measured on both arms in the office after 5 minutes rest. Arterial hypertension (HT) was defined as BP ≥140/90 mmHg. 24h ambulatory BP measurement (ABPM) was performed with a device for noninvasive continuous BP monitoring on the same day. 24h-, day- and nighttime HT was defined as ≥130/80, ≥135/85 and ≥120/70mmHg, respectively. Non-dipping was defined as a nocturnal BP decrease of <10%.
Results
66 patients were enrolled between April 2015 and December 2015. Median age at study entry was 56 (range 22-73) with median 9 (range 1-29) years after transplantation. 47% of the patients were female. Nine (14%) patients had a BMI ≥30kg/m2, 19 (29%) patients had a sedentary lifestyle and 12 (18%) patients were current smokers. Fifteen (23%) patients had treatment with calcineurin inhibitors and 4 (6%) patients had cortison. Thirty patients (45%) had office HT: Isolated systolic, isolated diastolic and combined HT was documented in 17, 2, and 11 patients, respectively. Systolic BP difference between arms of ≥20mmHg was measured in 3 patients. 24h- HT was documented in 41 patients (62%) with 6 systolic, 8 diastolic and 27 systolic and diastolic HT patterns. 32 (48%) patients had day-time HT and 54 (82%) patients had nighttime HT. 48 (73%) patients were non-dippers. White-coat HT and masked HT was diagnosed in 2 (3%) and 12 patients (18%), respectively. 32 (48%) had treatment with antihypertensive drugs. However, 23 patients were still hypertensive, 17 patients detected with office BP and further 6 patients were hypertensive on ABPM.
Conclusion
Arterial hypertension is common in patients after allogeneic HSCT and is often missed by office BP measurements only. ABPM detects patients with relevant night-time hypertension. ABPM may lead to better treatment of hypertension.
Session topic: E-poster
Keyword(s): Hematopoietic cell transplantation, Long-term follow-up
Type: Publication Only
Background
Improvement of transplantation techniques and supportive care lead to an increasing number of long-term survivors after allogeneic hematopoietic stem cell transplantation (HSCT). Recipients of allogeneic HSCT have a higher prevalence of cardiovascular risk factors.
Aims
To determine the prevalence of ambulatory hypertension in patients after HSCT.
Methods
Patients ≥1 year after allogeneic HSCT were included during their annual hematological check at University Hospital Basel, Switzerland. Blood pressure (BP) was measured on both arms in the office after 5 minutes rest. Arterial hypertension (HT) was defined as BP ≥140/90 mmHg. 24h ambulatory BP measurement (ABPM) was performed with a device for noninvasive continuous BP monitoring on the same day. 24h-, day- and nighttime HT was defined as ≥130/80, ≥135/85 and ≥120/70mmHg, respectively. Non-dipping was defined as a nocturnal BP decrease of <10%.
Results
66 patients were enrolled between April 2015 and December 2015. Median age at study entry was 56 (range 22-73) with median 9 (range 1-29) years after transplantation. 47% of the patients were female. Nine (14%) patients had a BMI ≥30kg/m2, 19 (29%) patients had a sedentary lifestyle and 12 (18%) patients were current smokers. Fifteen (23%) patients had treatment with calcineurin inhibitors and 4 (6%) patients had cortison. Thirty patients (45%) had office HT: Isolated systolic, isolated diastolic and combined HT was documented in 17, 2, and 11 patients, respectively. Systolic BP difference between arms of ≥20mmHg was measured in 3 patients. 24h- HT was documented in 41 patients (62%) with 6 systolic, 8 diastolic and 27 systolic and diastolic HT patterns. 32 (48%) patients had day-time HT and 54 (82%) patients had nighttime HT. 48 (73%) patients were non-dippers. White-coat HT and masked HT was diagnosed in 2 (3%) and 12 patients (18%), respectively. 32 (48%) had treatment with antihypertensive drugs. However, 23 patients were still hypertensive, 17 patients detected with office BP and further 6 patients were hypertensive on ABPM.
Conclusion
Arterial hypertension is common in patients after allogeneic HSCT and is often missed by office BP measurements only. ABPM detects patients with relevant night-time hypertension. ABPM may lead to better treatment of hypertension.
Session topic: E-poster
Keyword(s): Hematopoietic cell transplantation, Long-term follow-up
Abstract: PB2180
Type: Publication Only
Background
Improvement of transplantation techniques and supportive care lead to an increasing number of long-term survivors after allogeneic hematopoietic stem cell transplantation (HSCT). Recipients of allogeneic HSCT have a higher prevalence of cardiovascular risk factors.
Aims
To determine the prevalence of ambulatory hypertension in patients after HSCT.
Methods
Patients ≥1 year after allogeneic HSCT were included during their annual hematological check at University Hospital Basel, Switzerland. Blood pressure (BP) was measured on both arms in the office after 5 minutes rest. Arterial hypertension (HT) was defined as BP ≥140/90 mmHg. 24h ambulatory BP measurement (ABPM) was performed with a device for noninvasive continuous BP monitoring on the same day. 24h-, day- and nighttime HT was defined as ≥130/80, ≥135/85 and ≥120/70mmHg, respectively. Non-dipping was defined as a nocturnal BP decrease of <10%.
Results
66 patients were enrolled between April 2015 and December 2015. Median age at study entry was 56 (range 22-73) with median 9 (range 1-29) years after transplantation. 47% of the patients were female. Nine (14%) patients had a BMI ≥30kg/m2, 19 (29%) patients had a sedentary lifestyle and 12 (18%) patients were current smokers. Fifteen (23%) patients had treatment with calcineurin inhibitors and 4 (6%) patients had cortison. Thirty patients (45%) had office HT: Isolated systolic, isolated diastolic and combined HT was documented in 17, 2, and 11 patients, respectively. Systolic BP difference between arms of ≥20mmHg was measured in 3 patients. 24h- HT was documented in 41 patients (62%) with 6 systolic, 8 diastolic and 27 systolic and diastolic HT patterns. 32 (48%) patients had day-time HT and 54 (82%) patients had nighttime HT. 48 (73%) patients were non-dippers. White-coat HT and masked HT was diagnosed in 2 (3%) and 12 patients (18%), respectively. 32 (48%) had treatment with antihypertensive drugs. However, 23 patients were still hypertensive, 17 patients detected with office BP and further 6 patients were hypertensive on ABPM.
Conclusion
Arterial hypertension is common in patients after allogeneic HSCT and is often missed by office BP measurements only. ABPM detects patients with relevant night-time hypertension. ABPM may lead to better treatment of hypertension.
Session topic: E-poster
Keyword(s): Hematopoietic cell transplantation, Long-term follow-up
Type: Publication Only
Background
Improvement of transplantation techniques and supportive care lead to an increasing number of long-term survivors after allogeneic hematopoietic stem cell transplantation (HSCT). Recipients of allogeneic HSCT have a higher prevalence of cardiovascular risk factors.
Aims
To determine the prevalence of ambulatory hypertension in patients after HSCT.
Methods
Patients ≥1 year after allogeneic HSCT were included during their annual hematological check at University Hospital Basel, Switzerland. Blood pressure (BP) was measured on both arms in the office after 5 minutes rest. Arterial hypertension (HT) was defined as BP ≥140/90 mmHg. 24h ambulatory BP measurement (ABPM) was performed with a device for noninvasive continuous BP monitoring on the same day. 24h-, day- and nighttime HT was defined as ≥130/80, ≥135/85 and ≥120/70mmHg, respectively. Non-dipping was defined as a nocturnal BP decrease of <10%.
Results
66 patients were enrolled between April 2015 and December 2015. Median age at study entry was 56 (range 22-73) with median 9 (range 1-29) years after transplantation. 47% of the patients were female. Nine (14%) patients had a BMI ≥30kg/m2, 19 (29%) patients had a sedentary lifestyle and 12 (18%) patients were current smokers. Fifteen (23%) patients had treatment with calcineurin inhibitors and 4 (6%) patients had cortison. Thirty patients (45%) had office HT: Isolated systolic, isolated diastolic and combined HT was documented in 17, 2, and 11 patients, respectively. Systolic BP difference between arms of ≥20mmHg was measured in 3 patients. 24h- HT was documented in 41 patients (62%) with 6 systolic, 8 diastolic and 27 systolic and diastolic HT patterns. 32 (48%) patients had day-time HT and 54 (82%) patients had nighttime HT. 48 (73%) patients were non-dippers. White-coat HT and masked HT was diagnosed in 2 (3%) and 12 patients (18%), respectively. 32 (48%) had treatment with antihypertensive drugs. However, 23 patients were still hypertensive, 17 patients detected with office BP and further 6 patients were hypertensive on ABPM.
Conclusion
Arterial hypertension is common in patients after allogeneic HSCT and is often missed by office BP measurements only. ABPM detects patients with relevant night-time hypertension. ABPM may lead to better treatment of hypertension.
Session topic: E-poster
Keyword(s): Hematopoietic cell transplantation, Long-term follow-up
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