SHOULD WE ALWAYS USE THE MCV TO DEFINE ANAEMIA?
(Abstract release date: 05/19/16)
EHA Library. Thomas W. 06/09/16; 135045; PB2145
Dr. Wayne Thomas
Contributions
Contributions
Abstract
Abstract: PB2145
Type: Publication Only
Background
How reliable is it to base testing serum ferritin on the presence of a microcytic anaemia? Traditional use of the term ‘hypochromic microcytic anaemia’ has fallen from favour. Most publications now concentrate on the ‘microcytic anaemias’.
Aims
The aim of this study was to ascertain in a large regional teaching Hospital whether MCH or MCV is better at predicting for a low serum ferritin (SF) indicative of iron deficiency.
Methods
This study was based upon data extracted from our Hospital’s laboratory information and results management system. Our large combined laboratory uses Sysmex XE2100 analysers. The majority of UK haematology labs use Sysmex analysers.We collected a year’s worth of full blood count (FBC) data and paired the results with serum ferritin values that were just below the lower limit of normal range. The request for SF had to be made within 4 weeks of the FBC.
Results
Of the 501 patient samples that could be paired, a greater proportion of serum ferritin levels between 10 and 12 mcg/l inclusive, showed hypochromia in comparison to microcytosis (72% vs 31% respectively). The median results were: Haemoglobin 117g/l, MCV 83.6fl, MCH 26.6pg (men and women combined).Over a four day period by analysis of 100 consecutive samples microcytosis was observed to be the greater trigger for a serum ferritin request compared to hypochromia (39% vs 28% respectively). Over the same 4 day period, of approximately 7000 samples, hypochromia was seen in 6% and microcytosis in 3%.
Conclusion
In conclusion, although in the literature and in practice microcytosis is the predominant trigger for serum ferritin testing, it is hypochromia that has the better predictive capacity in our laboratory for the presence of iron deficiency. Clinicians need to look at the MCH and consider iron deficiency when the value is low, even in the presence of a normal MCV.
Session topic: E-poster
Keyword(s): Iron deficiency
Type: Publication Only
Background
How reliable is it to base testing serum ferritin on the presence of a microcytic anaemia? Traditional use of the term ‘hypochromic microcytic anaemia’ has fallen from favour. Most publications now concentrate on the ‘microcytic anaemias’.
Aims
The aim of this study was to ascertain in a large regional teaching Hospital whether MCH or MCV is better at predicting for a low serum ferritin (SF) indicative of iron deficiency.
Methods
This study was based upon data extracted from our Hospital’s laboratory information and results management system. Our large combined laboratory uses Sysmex XE2100 analysers. The majority of UK haematology labs use Sysmex analysers.We collected a year’s worth of full blood count (FBC) data and paired the results with serum ferritin values that were just below the lower limit of normal range. The request for SF had to be made within 4 weeks of the FBC.
Results
Of the 501 patient samples that could be paired, a greater proportion of serum ferritin levels between 10 and 12 mcg/l inclusive, showed hypochromia in comparison to microcytosis (72% vs 31% respectively). The median results were: Haemoglobin 117g/l, MCV 83.6fl, MCH 26.6pg (men and women combined).Over a four day period by analysis of 100 consecutive samples microcytosis was observed to be the greater trigger for a serum ferritin request compared to hypochromia (39% vs 28% respectively). Over the same 4 day period, of approximately 7000 samples, hypochromia was seen in 6% and microcytosis in 3%.
Conclusion
In conclusion, although in the literature and in practice microcytosis is the predominant trigger for serum ferritin testing, it is hypochromia that has the better predictive capacity in our laboratory for the presence of iron deficiency. Clinicians need to look at the MCH and consider iron deficiency when the value is low, even in the presence of a normal MCV.
Session topic: E-poster
Keyword(s): Iron deficiency
Abstract: PB2145
Type: Publication Only
Background
How reliable is it to base testing serum ferritin on the presence of a microcytic anaemia? Traditional use of the term ‘hypochromic microcytic anaemia’ has fallen from favour. Most publications now concentrate on the ‘microcytic anaemias’.
Aims
The aim of this study was to ascertain in a large regional teaching Hospital whether MCH or MCV is better at predicting for a low serum ferritin (SF) indicative of iron deficiency.
Methods
This study was based upon data extracted from our Hospital’s laboratory information and results management system. Our large combined laboratory uses Sysmex XE2100 analysers. The majority of UK haematology labs use Sysmex analysers.We collected a year’s worth of full blood count (FBC) data and paired the results with serum ferritin values that were just below the lower limit of normal range. The request for SF had to be made within 4 weeks of the FBC.
Results
Of the 501 patient samples that could be paired, a greater proportion of serum ferritin levels between 10 and 12 mcg/l inclusive, showed hypochromia in comparison to microcytosis (72% vs 31% respectively). The median results were: Haemoglobin 117g/l, MCV 83.6fl, MCH 26.6pg (men and women combined).Over a four day period by analysis of 100 consecutive samples microcytosis was observed to be the greater trigger for a serum ferritin request compared to hypochromia (39% vs 28% respectively). Over the same 4 day period, of approximately 7000 samples, hypochromia was seen in 6% and microcytosis in 3%.
Conclusion
In conclusion, although in the literature and in practice microcytosis is the predominant trigger for serum ferritin testing, it is hypochromia that has the better predictive capacity in our laboratory for the presence of iron deficiency. Clinicians need to look at the MCH and consider iron deficiency when the value is low, even in the presence of a normal MCV.
Session topic: E-poster
Keyword(s): Iron deficiency
Type: Publication Only
Background
How reliable is it to base testing serum ferritin on the presence of a microcytic anaemia? Traditional use of the term ‘hypochromic microcytic anaemia’ has fallen from favour. Most publications now concentrate on the ‘microcytic anaemias’.
Aims
The aim of this study was to ascertain in a large regional teaching Hospital whether MCH or MCV is better at predicting for a low serum ferritin (SF) indicative of iron deficiency.
Methods
This study was based upon data extracted from our Hospital’s laboratory information and results management system. Our large combined laboratory uses Sysmex XE2100 analysers. The majority of UK haematology labs use Sysmex analysers.We collected a year’s worth of full blood count (FBC) data and paired the results with serum ferritin values that were just below the lower limit of normal range. The request for SF had to be made within 4 weeks of the FBC.
Results
Of the 501 patient samples that could be paired, a greater proportion of serum ferritin levels between 10 and 12 mcg/l inclusive, showed hypochromia in comparison to microcytosis (72% vs 31% respectively). The median results were: Haemoglobin 117g/l, MCV 83.6fl, MCH 26.6pg (men and women combined).Over a four day period by analysis of 100 consecutive samples microcytosis was observed to be the greater trigger for a serum ferritin request compared to hypochromia (39% vs 28% respectively). Over the same 4 day period, of approximately 7000 samples, hypochromia was seen in 6% and microcytosis in 3%.
Conclusion
In conclusion, although in the literature and in practice microcytosis is the predominant trigger for serum ferritin testing, it is hypochromia that has the better predictive capacity in our laboratory for the presence of iron deficiency. Clinicians need to look at the MCH and consider iron deficiency when the value is low, even in the presence of a normal MCV.
Session topic: E-poster
Keyword(s): Iron deficiency
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