IRON STATUS IN BETA THALASSAEMIA TRAIT
(Abstract release date: 05/19/16)
EHA Library. Yousafzai Y. 06/09/16; 135037; PB2137
Yasar M Yousafzai
Contributions
Contributions
Abstract
Abstract: PB2137
Type: Publication Only
Background
Iron overload remains the cause of morbidity and mortality in patients with beta thalassaemia major. Repeated transfusions and ineffective erythropoiesis lead to excessive iron stores in the body. However, not much is known about the status of iron in carriers of beta thalassaemia mutation. In Pakistan nearly 1/3rd population has iron deficiency and the policymakers have suggested global flour fortification with iron. This may have implications for the nearly 7% BTT population. Without knowing whether the BTT individuals are prone to develop iron overload or deficiency, this may be potentially harmful to such individuals.
Aims
The aim of this study was to determine whether carriers of beta thalassaemia trait could develop iron deficiency or iron overload.
Methods
Beta thalassaemia trait was diagnosed with HPLC (HbA2> 3%) and serum Ferritin levels were measured using sandwitch ELISA method. A total of 101 individuals (50 males and 51 females) with BTT were assessed for serum ferritin levels. None of these subjects were on oral or injectable iron therapy or has any recent inflammatory event.
Results
Overall, 93% carriers of beta thalassaemia trait were anaemic whereas 7% had Hb within the normal range. Serum ferritin levels of 18.8% were low (mean serum ferritin while 8.3±4.25 ng/ml) while 75.2% individuals were iron replete. Interestingly, 6% individuals had serum ferritin levels higher (mean 911 ± 788 ng/ml) than the reference range. This iron overload was more common in adults (4%) and males (4%). The results imply that iron deficiency a common occuring in beta thalassaemia trait individuals in Pakistan. However, a smaller proportion of carriers may also develop iron overload.
Conclusion
This pilot study was carried out to determine the status of iron balance in beta thalassaemia trait individuals. Both iron deficiency and overload were observed. These findings are significant and provide a rationale for more robust epidemiological studies.
Session topic: E-poster
Keyword(s): Beta thalassemia, Iron deficiency, Iron overload, Thalassemia
Type: Publication Only
Background
Iron overload remains the cause of morbidity and mortality in patients with beta thalassaemia major. Repeated transfusions and ineffective erythropoiesis lead to excessive iron stores in the body. However, not much is known about the status of iron in carriers of beta thalassaemia mutation. In Pakistan nearly 1/3rd population has iron deficiency and the policymakers have suggested global flour fortification with iron. This may have implications for the nearly 7% BTT population. Without knowing whether the BTT individuals are prone to develop iron overload or deficiency, this may be potentially harmful to such individuals.
Aims
The aim of this study was to determine whether carriers of beta thalassaemia trait could develop iron deficiency or iron overload.
Methods
Beta thalassaemia trait was diagnosed with HPLC (HbA2> 3%) and serum Ferritin levels were measured using sandwitch ELISA method. A total of 101 individuals (50 males and 51 females) with BTT were assessed for serum ferritin levels. None of these subjects were on oral or injectable iron therapy or has any recent inflammatory event.
Results
Overall, 93% carriers of beta thalassaemia trait were anaemic whereas 7% had Hb within the normal range. Serum ferritin levels of 18.8% were low (mean serum ferritin while 8.3±4.25 ng/ml) while 75.2% individuals were iron replete. Interestingly, 6% individuals had serum ferritin levels higher (mean 911 ± 788 ng/ml) than the reference range. This iron overload was more common in adults (4%) and males (4%). The results imply that iron deficiency a common occuring in beta thalassaemia trait individuals in Pakistan. However, a smaller proportion of carriers may also develop iron overload.
Conclusion
This pilot study was carried out to determine the status of iron balance in beta thalassaemia trait individuals. Both iron deficiency and overload were observed. These findings are significant and provide a rationale for more robust epidemiological studies.
Session topic: E-poster
Keyword(s): Beta thalassemia, Iron deficiency, Iron overload, Thalassemia
Abstract: PB2137
Type: Publication Only
Background
Iron overload remains the cause of morbidity and mortality in patients with beta thalassaemia major. Repeated transfusions and ineffective erythropoiesis lead to excessive iron stores in the body. However, not much is known about the status of iron in carriers of beta thalassaemia mutation. In Pakistan nearly 1/3rd population has iron deficiency and the policymakers have suggested global flour fortification with iron. This may have implications for the nearly 7% BTT population. Without knowing whether the BTT individuals are prone to develop iron overload or deficiency, this may be potentially harmful to such individuals.
Aims
The aim of this study was to determine whether carriers of beta thalassaemia trait could develop iron deficiency or iron overload.
Methods
Beta thalassaemia trait was diagnosed with HPLC (HbA2> 3%) and serum Ferritin levels were measured using sandwitch ELISA method. A total of 101 individuals (50 males and 51 females) with BTT were assessed for serum ferritin levels. None of these subjects were on oral or injectable iron therapy or has any recent inflammatory event.
Results
Overall, 93% carriers of beta thalassaemia trait were anaemic whereas 7% had Hb within the normal range. Serum ferritin levels of 18.8% were low (mean serum ferritin while 8.3±4.25 ng/ml) while 75.2% individuals were iron replete. Interestingly, 6% individuals had serum ferritin levels higher (mean 911 ± 788 ng/ml) than the reference range. This iron overload was more common in adults (4%) and males (4%). The results imply that iron deficiency a common occuring in beta thalassaemia trait individuals in Pakistan. However, a smaller proportion of carriers may also develop iron overload.
Conclusion
This pilot study was carried out to determine the status of iron balance in beta thalassaemia trait individuals. Both iron deficiency and overload were observed. These findings are significant and provide a rationale for more robust epidemiological studies.
Session topic: E-poster
Keyword(s): Beta thalassemia, Iron deficiency, Iron overload, Thalassemia
Type: Publication Only
Background
Iron overload remains the cause of morbidity and mortality in patients with beta thalassaemia major. Repeated transfusions and ineffective erythropoiesis lead to excessive iron stores in the body. However, not much is known about the status of iron in carriers of beta thalassaemia mutation. In Pakistan nearly 1/3rd population has iron deficiency and the policymakers have suggested global flour fortification with iron. This may have implications for the nearly 7% BTT population. Without knowing whether the BTT individuals are prone to develop iron overload or deficiency, this may be potentially harmful to such individuals.
Aims
The aim of this study was to determine whether carriers of beta thalassaemia trait could develop iron deficiency or iron overload.
Methods
Beta thalassaemia trait was diagnosed with HPLC (HbA2> 3%) and serum Ferritin levels were measured using sandwitch ELISA method. A total of 101 individuals (50 males and 51 females) with BTT were assessed for serum ferritin levels. None of these subjects were on oral or injectable iron therapy or has any recent inflammatory event.
Results
Overall, 93% carriers of beta thalassaemia trait were anaemic whereas 7% had Hb within the normal range. Serum ferritin levels of 18.8% were low (mean serum ferritin while 8.3±4.25 ng/ml) while 75.2% individuals were iron replete. Interestingly, 6% individuals had serum ferritin levels higher (mean 911 ± 788 ng/ml) than the reference range. This iron overload was more common in adults (4%) and males (4%). The results imply that iron deficiency a common occuring in beta thalassaemia trait individuals in Pakistan. However, a smaller proportion of carriers may also develop iron overload.
Conclusion
This pilot study was carried out to determine the status of iron balance in beta thalassaemia trait individuals. Both iron deficiency and overload were observed. These findings are significant and provide a rationale for more robust epidemiological studies.
Session topic: E-poster
Keyword(s): Beta thalassemia, Iron deficiency, Iron overload, Thalassemia
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