USE OF RADIATION THERAPY FOR THE TREATMENT OF SPLENOMEGALY IN NEOPLASTIC HEMATOLOGICAL DISORDERS
(Abstract release date: 05/19/16)
EHA Library. Gonzalez Diaz L. 06/09/16; 135015; PB2115
Laura Gonzalez Diaz
Contributions
Contributions
Abstract
Abstract: PB2115
Type: Publication Only
Background
Splenic irradiation has been used as first treatment for several hematological neoplasms, including chronic leukemia or myeloid malignancies, but with the availability of new drugs its application was restricted.
Aims
In selected cases, not only with palliative intentions, irradiation can be useful treatment modality
Methods
Our study included 13 patients: 5 with chronic lymphocytic leukemia, 6 with high-grade B-cell lymphoma and 2 with diagnose of polycythaemia Vera. In 5 patients the treatment was with radical intention (all of them with high grade lymphoma) and the rest were palliatives as treatment of pain or normalization of red blood cell that allows more time between transfusions. The doses were generally low with range between 5 and 10 Gy in 0.5Gy daily fractions because doses higher than 10Gy did not provide benefits according to literature.
Results
We got 5 complete responses confirmed by PET but after 2 years 2 of them relapsed and were treated with radiotherapy again with the same scheme and obtain the same response to the present day. In terms of palliative intention, splenic irradiation provided a relief of pail from 6 to 12 months, and in 4 patients the disease progressed without new splenic symptoms. One patient received 3 courses of radiotherapy for painful splenomegaly with a gap of 12, 9 and 6 months without acute toxicity and died due to non-splenic leukemia progression.
Conclusion
In selected patients who are not responsive, not suitable for systemic treatment or palliative, splenic irradiation can be an efficient therapy with little toxicity and sustained response over time.f of pail from 6 to 12 months, and in 4 patients the disease progressed without new splenic symptoms. One patient received 3 courses of radiotherapy for painful splenomegaly with a gap of 12, 9 and 6 months without acute toxicity and died due to non-splenic leukemia progression.
Session topic: E-poster
Keyword(s): Radiotherapy, Spleen
Type: Publication Only
Background
Splenic irradiation has been used as first treatment for several hematological neoplasms, including chronic leukemia or myeloid malignancies, but with the availability of new drugs its application was restricted.
Aims
In selected cases, not only with palliative intentions, irradiation can be useful treatment modality
Methods
Our study included 13 patients: 5 with chronic lymphocytic leukemia, 6 with high-grade B-cell lymphoma and 2 with diagnose of polycythaemia Vera. In 5 patients the treatment was with radical intention (all of them with high grade lymphoma) and the rest were palliatives as treatment of pain or normalization of red blood cell that allows more time between transfusions. The doses were generally low with range between 5 and 10 Gy in 0.5Gy daily fractions because doses higher than 10Gy did not provide benefits according to literature.
Results
We got 5 complete responses confirmed by PET but after 2 years 2 of them relapsed and were treated with radiotherapy again with the same scheme and obtain the same response to the present day. In terms of palliative intention, splenic irradiation provided a relief of pail from 6 to 12 months, and in 4 patients the disease progressed without new splenic symptoms. One patient received 3 courses of radiotherapy for painful splenomegaly with a gap of 12, 9 and 6 months without acute toxicity and died due to non-splenic leukemia progression.
Conclusion
In selected patients who are not responsive, not suitable for systemic treatment or palliative, splenic irradiation can be an efficient therapy with little toxicity and sustained response over time.f of pail from 6 to 12 months, and in 4 patients the disease progressed without new splenic symptoms. One patient received 3 courses of radiotherapy for painful splenomegaly with a gap of 12, 9 and 6 months without acute toxicity and died due to non-splenic leukemia progression.
Session topic: E-poster
Keyword(s): Radiotherapy, Spleen
Abstract: PB2115
Type: Publication Only
Background
Splenic irradiation has been used as first treatment for several hematological neoplasms, including chronic leukemia or myeloid malignancies, but with the availability of new drugs its application was restricted.
Aims
In selected cases, not only with palliative intentions, irradiation can be useful treatment modality
Methods
Our study included 13 patients: 5 with chronic lymphocytic leukemia, 6 with high-grade B-cell lymphoma and 2 with diagnose of polycythaemia Vera. In 5 patients the treatment was with radical intention (all of them with high grade lymphoma) and the rest were palliatives as treatment of pain or normalization of red blood cell that allows more time between transfusions. The doses were generally low with range between 5 and 10 Gy in 0.5Gy daily fractions because doses higher than 10Gy did not provide benefits according to literature.
Results
We got 5 complete responses confirmed by PET but after 2 years 2 of them relapsed and were treated with radiotherapy again with the same scheme and obtain the same response to the present day. In terms of palliative intention, splenic irradiation provided a relief of pail from 6 to 12 months, and in 4 patients the disease progressed without new splenic symptoms. One patient received 3 courses of radiotherapy for painful splenomegaly with a gap of 12, 9 and 6 months without acute toxicity and died due to non-splenic leukemia progression.
Conclusion
In selected patients who are not responsive, not suitable for systemic treatment or palliative, splenic irradiation can be an efficient therapy with little toxicity and sustained response over time.f of pail from 6 to 12 months, and in 4 patients the disease progressed without new splenic symptoms. One patient received 3 courses of radiotherapy for painful splenomegaly with a gap of 12, 9 and 6 months without acute toxicity and died due to non-splenic leukemia progression.
Session topic: E-poster
Keyword(s): Radiotherapy, Spleen
Type: Publication Only
Background
Splenic irradiation has been used as first treatment for several hematological neoplasms, including chronic leukemia or myeloid malignancies, but with the availability of new drugs its application was restricted.
Aims
In selected cases, not only with palliative intentions, irradiation can be useful treatment modality
Methods
Our study included 13 patients: 5 with chronic lymphocytic leukemia, 6 with high-grade B-cell lymphoma and 2 with diagnose of polycythaemia Vera. In 5 patients the treatment was with radical intention (all of them with high grade lymphoma) and the rest were palliatives as treatment of pain or normalization of red blood cell that allows more time between transfusions. The doses were generally low with range between 5 and 10 Gy in 0.5Gy daily fractions because doses higher than 10Gy did not provide benefits according to literature.
Results
We got 5 complete responses confirmed by PET but after 2 years 2 of them relapsed and were treated with radiotherapy again with the same scheme and obtain the same response to the present day. In terms of palliative intention, splenic irradiation provided a relief of pail from 6 to 12 months, and in 4 patients the disease progressed without new splenic symptoms. One patient received 3 courses of radiotherapy for painful splenomegaly with a gap of 12, 9 and 6 months without acute toxicity and died due to non-splenic leukemia progression.
Conclusion
In selected patients who are not responsive, not suitable for systemic treatment or palliative, splenic irradiation can be an efficient therapy with little toxicity and sustained response over time.f of pail from 6 to 12 months, and in 4 patients the disease progressed without new splenic symptoms. One patient received 3 courses of radiotherapy for painful splenomegaly with a gap of 12, 9 and 6 months without acute toxicity and died due to non-splenic leukemia progression.
Session topic: E-poster
Keyword(s): Radiotherapy, Spleen
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