A NEW MODEL OF ORAL HYGIEN FOR REDUCTION AND PREVENTION OF MUCOSITIS IN PATIENTS UNDERGOING MYELOABLATIVE STEM CELL TRANSPLANTATION
(Abstract release date: 05/19/16)
EHA Library. Stacchini V. 06/09/16; 135002; PB2102
Dr. Vittoria Stacchini
Contributions
Contributions
Abstract
Abstract: PB2102
Type: Publication Only
Background
Mucositis is a very common complication of allogeneic stem cell transplantation (allo-SCT). The damage due to radio-chemotherapy is combined with the risk of superinfection. Protocols of oral hygiene play an important role to prevent the onset of oral infections and may improve disconfort due to mucositis.
Aims
We are we presenting data on mucositis prevention using professional oral hygiene and specific dental aids.
Methods
We prospectively enrolled patients who underwent allo-SCT for haematological malignancies. We joined to standard procedures (toothbrush, clorexidine mouthwashes) a set of specific tools, with a daily schedule of application. An oral hygiene session was performed in all patients before the date of recovery. The protocol provide, from the first day of hospitalization, the use of: manual toothbrush with bristles of 0,12 mm of diameter, super-soft; antibacterial toothpaste containing colostrum and antimicrobial enzymes; antibacterial mouthwash containing lisozyme, lactoferrin, lactoperoxidase and extracted colostrum, fluorine, xilitole and aloe vera. From the day 1 after stem cell infusion: manual toothbrush with bristles of 0,10 mm of diameter, ultra-soft; mouthwash containing maltodextrin, propylene glycol, hydroxyethylcellulose, sodium hyaluronate, sodium saccarhin and citric acid. Patients were clinically supervised every day, until engraftment or resolution of mouth lesions, through clinical examination, WHO grading of mucositis, VAS scale for the pain.
Results
We prospectively enrolled 8 patients that underwent to myeloablative conditioning regiment with TBF for haematological malignancies, comparing results with an historical cohort. Results are expressed in figure.
Conclusion
Patients who followed a regular schedule of oral hygiene, before and after the transplant, had a lower pain reported in VAS scale, a significant lower level of mucosyte, and a later onset of mouth lesions, in comparison of patients who did not follow the procedure and in comparison of a control group, extracted by the clinical records of allo-SCTs of the previous year. It has implication for the administration of analgesic drugs (opioids), notably lower in patients treated with protocol. This finding demonstrate the importance of oral hygiene in allo-SCT setting in preventing high-grade mucosytis, suggesting the institution of specific profession of dental hygienist for haematological patients.
Session topic: E-poster
Keyword(s): Mucositis, Stem cell, Supportive care, Transplant
Type: Publication Only
Background
Mucositis is a very common complication of allogeneic stem cell transplantation (allo-SCT). The damage due to radio-chemotherapy is combined with the risk of superinfection. Protocols of oral hygiene play an important role to prevent the onset of oral infections and may improve disconfort due to mucositis.
Aims
We are we presenting data on mucositis prevention using professional oral hygiene and specific dental aids.
Methods
We prospectively enrolled patients who underwent allo-SCT for haematological malignancies. We joined to standard procedures (toothbrush, clorexidine mouthwashes) a set of specific tools, with a daily schedule of application. An oral hygiene session was performed in all patients before the date of recovery. The protocol provide, from the first day of hospitalization, the use of: manual toothbrush with bristles of 0,12 mm of diameter, super-soft; antibacterial toothpaste containing colostrum and antimicrobial enzymes; antibacterial mouthwash containing lisozyme, lactoferrin, lactoperoxidase and extracted colostrum, fluorine, xilitole and aloe vera. From the day 1 after stem cell infusion: manual toothbrush with bristles of 0,10 mm of diameter, ultra-soft; mouthwash containing maltodextrin, propylene glycol, hydroxyethylcellulose, sodium hyaluronate, sodium saccarhin and citric acid. Patients were clinically supervised every day, until engraftment or resolution of mouth lesions, through clinical examination, WHO grading of mucositis, VAS scale for the pain.
Results
We prospectively enrolled 8 patients that underwent to myeloablative conditioning regiment with TBF for haematological malignancies, comparing results with an historical cohort. Results are expressed in figure.
Conclusion
Patients who followed a regular schedule of oral hygiene, before and after the transplant, had a lower pain reported in VAS scale, a significant lower level of mucosyte, and a later onset of mouth lesions, in comparison of patients who did not follow the procedure and in comparison of a control group, extracted by the clinical records of allo-SCTs of the previous year. It has implication for the administration of analgesic drugs (opioids), notably lower in patients treated with protocol. This finding demonstrate the importance of oral hygiene in allo-SCT setting in preventing high-grade mucosytis, suggesting the institution of specific profession of dental hygienist for haematological patients.
Session topic: E-poster
Keyword(s): Mucositis, Stem cell, Supportive care, Transplant
Abstract: PB2102
Type: Publication Only
Background
Mucositis is a very common complication of allogeneic stem cell transplantation (allo-SCT). The damage due to radio-chemotherapy is combined with the risk of superinfection. Protocols of oral hygiene play an important role to prevent the onset of oral infections and may improve disconfort due to mucositis.
Aims
We are we presenting data on mucositis prevention using professional oral hygiene and specific dental aids.
Methods
We prospectively enrolled patients who underwent allo-SCT for haematological malignancies. We joined to standard procedures (toothbrush, clorexidine mouthwashes) a set of specific tools, with a daily schedule of application. An oral hygiene session was performed in all patients before the date of recovery. The protocol provide, from the first day of hospitalization, the use of: manual toothbrush with bristles of 0,12 mm of diameter, super-soft; antibacterial toothpaste containing colostrum and antimicrobial enzymes; antibacterial mouthwash containing lisozyme, lactoferrin, lactoperoxidase and extracted colostrum, fluorine, xilitole and aloe vera. From the day 1 after stem cell infusion: manual toothbrush with bristles of 0,10 mm of diameter, ultra-soft; mouthwash containing maltodextrin, propylene glycol, hydroxyethylcellulose, sodium hyaluronate, sodium saccarhin and citric acid. Patients were clinically supervised every day, until engraftment or resolution of mouth lesions, through clinical examination, WHO grading of mucositis, VAS scale for the pain.
Results
We prospectively enrolled 8 patients that underwent to myeloablative conditioning regiment with TBF for haematological malignancies, comparing results with an historical cohort. Results are expressed in figure.
Conclusion
Patients who followed a regular schedule of oral hygiene, before and after the transplant, had a lower pain reported in VAS scale, a significant lower level of mucosyte, and a later onset of mouth lesions, in comparison of patients who did not follow the procedure and in comparison of a control group, extracted by the clinical records of allo-SCTs of the previous year. It has implication for the administration of analgesic drugs (opioids), notably lower in patients treated with protocol. This finding demonstrate the importance of oral hygiene in allo-SCT setting in preventing high-grade mucosytis, suggesting the institution of specific profession of dental hygienist for haematological patients.
Session topic: E-poster
Keyword(s): Mucositis, Stem cell, Supportive care, Transplant
Type: Publication Only
Background
Mucositis is a very common complication of allogeneic stem cell transplantation (allo-SCT). The damage due to radio-chemotherapy is combined with the risk of superinfection. Protocols of oral hygiene play an important role to prevent the onset of oral infections and may improve disconfort due to mucositis.
Aims
We are we presenting data on mucositis prevention using professional oral hygiene and specific dental aids.
Methods
We prospectively enrolled patients who underwent allo-SCT for haematological malignancies. We joined to standard procedures (toothbrush, clorexidine mouthwashes) a set of specific tools, with a daily schedule of application. An oral hygiene session was performed in all patients before the date of recovery. The protocol provide, from the first day of hospitalization, the use of: manual toothbrush with bristles of 0,12 mm of diameter, super-soft; antibacterial toothpaste containing colostrum and antimicrobial enzymes; antibacterial mouthwash containing lisozyme, lactoferrin, lactoperoxidase and extracted colostrum, fluorine, xilitole and aloe vera. From the day 1 after stem cell infusion: manual toothbrush with bristles of 0,10 mm of diameter, ultra-soft; mouthwash containing maltodextrin, propylene glycol, hydroxyethylcellulose, sodium hyaluronate, sodium saccarhin and citric acid. Patients were clinically supervised every day, until engraftment or resolution of mouth lesions, through clinical examination, WHO grading of mucositis, VAS scale for the pain.
Results
We prospectively enrolled 8 patients that underwent to myeloablative conditioning regiment with TBF for haematological malignancies, comparing results with an historical cohort. Results are expressed in figure.
Conclusion
Patients who followed a regular schedule of oral hygiene, before and after the transplant, had a lower pain reported in VAS scale, a significant lower level of mucosyte, and a later onset of mouth lesions, in comparison of patients who did not follow the procedure and in comparison of a control group, extracted by the clinical records of allo-SCTs of the previous year. It has implication for the administration of analgesic drugs (opioids), notably lower in patients treated with protocol. This finding demonstrate the importance of oral hygiene in allo-SCT setting in preventing high-grade mucosytis, suggesting the institution of specific profession of dental hygienist for haematological patients.
Session topic: E-poster
Keyword(s): Mucositis, Stem cell, Supportive care, Transplant
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