INTERLEUKIN 31 AS A MARKER OF ALLERGY IN IMMUNE THROMBOCYTOPENIA IN CHILDREN
(Abstract release date: 05/19/16)
EHA Library. tantawy a. 06/09/16; 134976; PB2076
Prof. azza tantawy
Contributions
Contributions
Abstract
Abstract: PB2076
Type: Publication Only
Background
Allergy and autoimmunity are two potential outcomes of dysregulated immunity both are characterized by inflammatory reaction that leads to the injury of target tissues. Interleukin-31 (IL31) is a recently discovered cytokine expressed in many human tissues, predominantly by activated CD4(+) T cells and has integral role in allergy pathogenesis.
Aims
to evaluate the relation between ITP and allergy in children by questionnaire for allergic manifestations and measuring serum IL31 and serum IgE..
Methods
62 ITP patients aged 1-18 years (median 6 years) were included, 36 had chronic ITP and 26 acute ITP, male to female ratio was 4:1, and were compared to 30 age and sex matched controls.All were subjected to: determination of allergy score by questionnaire, measuring IgE level (RAST method) and ELISA serum IL31 level assessment.
Results
Compared to controls, ITP patients had signinificantly higher allergy score ( p<0.001), higher IL31 level ( p=0.000), but non significant difference in serum Ig E levels.There was statistically significant higher IL31 level in allergy positive score ITP patients compared to allergy negative score patients ( p=0.000), and statistically significant positive correlation between IL31 level and score of allergy ( r=0.646, p=0.000).There was no correlation between serum IgE level and score of allergy,and no significant difference between patients and controls regarding serum IgE level . There was no significant difference between acute and chronic ITP in the score of allergy, IgE level or IL31levels, and there was no difference in these parameters between steroid responsive and steroid resistant ITP patients.
Conclusion
This preliminary study reveals that children with allergic manifestations are at higher risk to develop ITP, but this will not probably affect the clinical presentation, treatment outcome or prognosis of immune thrombocytopenia.
Session topic: E-poster
Keyword(s): Immune thrombocytopenia (ITP)
Type: Publication Only
Background
Allergy and autoimmunity are two potential outcomes of dysregulated immunity both are characterized by inflammatory reaction that leads to the injury of target tissues. Interleukin-31 (IL31) is a recently discovered cytokine expressed in many human tissues, predominantly by activated CD4(+) T cells and has integral role in allergy pathogenesis.
Aims
to evaluate the relation between ITP and allergy in children by questionnaire for allergic manifestations and measuring serum IL31 and serum IgE..
Methods
62 ITP patients aged 1-18 years (median 6 years) were included, 36 had chronic ITP and 26 acute ITP, male to female ratio was 4:1, and were compared to 30 age and sex matched controls.All were subjected to: determination of allergy score by questionnaire, measuring IgE level (RAST method) and ELISA serum IL31 level assessment.
Results
Compared to controls, ITP patients had signinificantly higher allergy score ( p<0.001), higher IL31 level ( p=0.000), but non significant difference in serum Ig E levels.There was statistically significant higher IL31 level in allergy positive score ITP patients compared to allergy negative score patients ( p=0.000), and statistically significant positive correlation between IL31 level and score of allergy ( r=0.646, p=0.000).There was no correlation between serum IgE level and score of allergy,and no significant difference between patients and controls regarding serum IgE level . There was no significant difference between acute and chronic ITP in the score of allergy, IgE level or IL31levels, and there was no difference in these parameters between steroid responsive and steroid resistant ITP patients.
Conclusion
This preliminary study reveals that children with allergic manifestations are at higher risk to develop ITP, but this will not probably affect the clinical presentation, treatment outcome or prognosis of immune thrombocytopenia.
Session topic: E-poster
Keyword(s): Immune thrombocytopenia (ITP)
Abstract: PB2076
Type: Publication Only
Background
Allergy and autoimmunity are two potential outcomes of dysregulated immunity both are characterized by inflammatory reaction that leads to the injury of target tissues. Interleukin-31 (IL31) is a recently discovered cytokine expressed in many human tissues, predominantly by activated CD4(+) T cells and has integral role in allergy pathogenesis.
Aims
to evaluate the relation between ITP and allergy in children by questionnaire for allergic manifestations and measuring serum IL31 and serum IgE..
Methods
62 ITP patients aged 1-18 years (median 6 years) were included, 36 had chronic ITP and 26 acute ITP, male to female ratio was 4:1, and were compared to 30 age and sex matched controls.All were subjected to: determination of allergy score by questionnaire, measuring IgE level (RAST method) and ELISA serum IL31 level assessment.
Results
Compared to controls, ITP patients had signinificantly higher allergy score ( p<0.001), higher IL31 level ( p=0.000), but non significant difference in serum Ig E levels.There was statistically significant higher IL31 level in allergy positive score ITP patients compared to allergy negative score patients ( p=0.000), and statistically significant positive correlation between IL31 level and score of allergy ( r=0.646, p=0.000).There was no correlation between serum IgE level and score of allergy,and no significant difference between patients and controls regarding serum IgE level . There was no significant difference between acute and chronic ITP in the score of allergy, IgE level or IL31levels, and there was no difference in these parameters between steroid responsive and steroid resistant ITP patients.
Conclusion
This preliminary study reveals that children with allergic manifestations are at higher risk to develop ITP, but this will not probably affect the clinical presentation, treatment outcome or prognosis of immune thrombocytopenia.
Session topic: E-poster
Keyword(s): Immune thrombocytopenia (ITP)
Type: Publication Only
Background
Allergy and autoimmunity are two potential outcomes of dysregulated immunity both are characterized by inflammatory reaction that leads to the injury of target tissues. Interleukin-31 (IL31) is a recently discovered cytokine expressed in many human tissues, predominantly by activated CD4(+) T cells and has integral role in allergy pathogenesis.
Aims
to evaluate the relation between ITP and allergy in children by questionnaire for allergic manifestations and measuring serum IL31 and serum IgE..
Methods
62 ITP patients aged 1-18 years (median 6 years) were included, 36 had chronic ITP and 26 acute ITP, male to female ratio was 4:1, and were compared to 30 age and sex matched controls.All were subjected to: determination of allergy score by questionnaire, measuring IgE level (RAST method) and ELISA serum IL31 level assessment.
Results
Compared to controls, ITP patients had signinificantly higher allergy score ( p<0.001), higher IL31 level ( p=0.000), but non significant difference in serum Ig E levels.There was statistically significant higher IL31 level in allergy positive score ITP patients compared to allergy negative score patients ( p=0.000), and statistically significant positive correlation between IL31 level and score of allergy ( r=0.646, p=0.000).There was no correlation between serum IgE level and score of allergy,and no significant difference between patients and controls regarding serum IgE level . There was no significant difference between acute and chronic ITP in the score of allergy, IgE level or IL31levels, and there was no difference in these parameters between steroid responsive and steroid resistant ITP patients.
Conclusion
This preliminary study reveals that children with allergic manifestations are at higher risk to develop ITP, but this will not probably affect the clinical presentation, treatment outcome or prognosis of immune thrombocytopenia.
Session topic: E-poster
Keyword(s): Immune thrombocytopenia (ITP)
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