PLATELET DISTRIBUTION WIDTH IS ELEVATED IN IMMUNE THROMBOCYTOPENIC PURPURA, BUT THE VALUES REPORTED IN XN-3000 AND ADVIA2120I WERE NOT COMPATIBLE
(Abstract release date: 05/19/16)
EHA Library. Lee Y. 06/09/16; 134975; PB2075
Prof. Dr. Young Kyung Lee
Contributions
Contributions
Abstract
Abstract: PB2075
Type: Publication Only
Background
Platelet distribution width (PDW) value as well as its unit is reported through different algorithms in different hematologic analyzers, and the correlation between PDW values in different hematologic analyzers has never been explored. Recently, PDW is indicated as a marker estimating the status of platelet production.
Aims
As the clinical significance of PDW is increasing, but not yet established, we analyzed the correlation between PDW values reported in Advia 2120i and XN-3000. We also compared the PDW values in immune thrombocytopenic purpura (ITP) and essential thrombocythemia (ET).
Methods
PDW was measured in 153 healthy individuals as a control group using both instruments. Twenty-three ITPs and 15 ITPs were tested using Advia 2120i and in XN-3000, respectively. ET group consists of 15 in Advia 2120i and 18 in XN-3000.
Results
In the control group, PDW did not correlated with platelet count, mean platelet volume (MPV), and age in Advia 2120i. In XN-3000, PDW did not correlated with platelet count or age, either, however, PDW significantly correlated with MPV (y = 2.034x − 9.111, r2 = 0.916, p < 0.001). PDW values reported in the two instruments did not correlate with each other (y = 0.184x + 2.592, r2 = 0.474, p < 0.001). The reference value was 40.0% ~ 64.2% in Advia 2120i, and 9.0 fL ~ 16.0 fL in XN-3000. PDW was elevated in ITP in both instruments compared with control group (median PDW 63.1% vs. 50.5% in Advia 2120i; 14.9 fL vs. 11.9 fL in XN-3000) with statistical significance (p < 0.001). PDW was elevated in ET in Advia 2120i (59.1%, p < 0.0001), but decreased in XN-3000 (10.0 fL, p < 0.001).
Conclusion
We analyzed the correlation of PDW values reported in Advia 2120i and XN-3000 for the first time, and showed that they are not compatible. PDW was affected by MPV in XN-3000, probably due to the calculation algorithm. PDW was elevated in ITP, suggesting the high proportion of large young platelets in this disease. However, the changes in PDW in ET were opposite in the two instruments, which requires further investigation.
Session topic: E-poster
Keyword(s): ITP, Platelet
Type: Publication Only
Background
Platelet distribution width (PDW) value as well as its unit is reported through different algorithms in different hematologic analyzers, and the correlation between PDW values in different hematologic analyzers has never been explored. Recently, PDW is indicated as a marker estimating the status of platelet production.
Aims
As the clinical significance of PDW is increasing, but not yet established, we analyzed the correlation between PDW values reported in Advia 2120i and XN-3000. We also compared the PDW values in immune thrombocytopenic purpura (ITP) and essential thrombocythemia (ET).
Methods
PDW was measured in 153 healthy individuals as a control group using both instruments. Twenty-three ITPs and 15 ITPs were tested using Advia 2120i and in XN-3000, respectively. ET group consists of 15 in Advia 2120i and 18 in XN-3000.
Results
In the control group, PDW did not correlated with platelet count, mean platelet volume (MPV), and age in Advia 2120i. In XN-3000, PDW did not correlated with platelet count or age, either, however, PDW significantly correlated with MPV (y = 2.034x − 9.111, r2 = 0.916, p < 0.001). PDW values reported in the two instruments did not correlate with each other (y = 0.184x + 2.592, r2 = 0.474, p < 0.001). The reference value was 40.0% ~ 64.2% in Advia 2120i, and 9.0 fL ~ 16.0 fL in XN-3000. PDW was elevated in ITP in both instruments compared with control group (median PDW 63.1% vs. 50.5% in Advia 2120i; 14.9 fL vs. 11.9 fL in XN-3000) with statistical significance (p < 0.001). PDW was elevated in ET in Advia 2120i (59.1%, p < 0.0001), but decreased in XN-3000 (10.0 fL, p < 0.001).
Conclusion
We analyzed the correlation of PDW values reported in Advia 2120i and XN-3000 for the first time, and showed that they are not compatible. PDW was affected by MPV in XN-3000, probably due to the calculation algorithm. PDW was elevated in ITP, suggesting the high proportion of large young platelets in this disease. However, the changes in PDW in ET were opposite in the two instruments, which requires further investigation.
Session topic: E-poster
Keyword(s): ITP, Platelet
Abstract: PB2075
Type: Publication Only
Background
Platelet distribution width (PDW) value as well as its unit is reported through different algorithms in different hematologic analyzers, and the correlation between PDW values in different hematologic analyzers has never been explored. Recently, PDW is indicated as a marker estimating the status of platelet production.
Aims
As the clinical significance of PDW is increasing, but not yet established, we analyzed the correlation between PDW values reported in Advia 2120i and XN-3000. We also compared the PDW values in immune thrombocytopenic purpura (ITP) and essential thrombocythemia (ET).
Methods
PDW was measured in 153 healthy individuals as a control group using both instruments. Twenty-three ITPs and 15 ITPs were tested using Advia 2120i and in XN-3000, respectively. ET group consists of 15 in Advia 2120i and 18 in XN-3000.
Results
In the control group, PDW did not correlated with platelet count, mean platelet volume (MPV), and age in Advia 2120i. In XN-3000, PDW did not correlated with platelet count or age, either, however, PDW significantly correlated with MPV (y = 2.034x − 9.111, r2 = 0.916, p < 0.001). PDW values reported in the two instruments did not correlate with each other (y = 0.184x + 2.592, r2 = 0.474, p < 0.001). The reference value was 40.0% ~ 64.2% in Advia 2120i, and 9.0 fL ~ 16.0 fL in XN-3000. PDW was elevated in ITP in both instruments compared with control group (median PDW 63.1% vs. 50.5% in Advia 2120i; 14.9 fL vs. 11.9 fL in XN-3000) with statistical significance (p < 0.001). PDW was elevated in ET in Advia 2120i (59.1%, p < 0.0001), but decreased in XN-3000 (10.0 fL, p < 0.001).
Conclusion
We analyzed the correlation of PDW values reported in Advia 2120i and XN-3000 for the first time, and showed that they are not compatible. PDW was affected by MPV in XN-3000, probably due to the calculation algorithm. PDW was elevated in ITP, suggesting the high proportion of large young platelets in this disease. However, the changes in PDW in ET were opposite in the two instruments, which requires further investigation.
Session topic: E-poster
Keyword(s): ITP, Platelet
Type: Publication Only
Background
Platelet distribution width (PDW) value as well as its unit is reported through different algorithms in different hematologic analyzers, and the correlation between PDW values in different hematologic analyzers has never been explored. Recently, PDW is indicated as a marker estimating the status of platelet production.
Aims
As the clinical significance of PDW is increasing, but not yet established, we analyzed the correlation between PDW values reported in Advia 2120i and XN-3000. We also compared the PDW values in immune thrombocytopenic purpura (ITP) and essential thrombocythemia (ET).
Methods
PDW was measured in 153 healthy individuals as a control group using both instruments. Twenty-three ITPs and 15 ITPs were tested using Advia 2120i and in XN-3000, respectively. ET group consists of 15 in Advia 2120i and 18 in XN-3000.
Results
In the control group, PDW did not correlated with platelet count, mean platelet volume (MPV), and age in Advia 2120i. In XN-3000, PDW did not correlated with platelet count or age, either, however, PDW significantly correlated with MPV (y = 2.034x − 9.111, r2 = 0.916, p < 0.001). PDW values reported in the two instruments did not correlate with each other (y = 0.184x + 2.592, r2 = 0.474, p < 0.001). The reference value was 40.0% ~ 64.2% in Advia 2120i, and 9.0 fL ~ 16.0 fL in XN-3000. PDW was elevated in ITP in both instruments compared with control group (median PDW 63.1% vs. 50.5% in Advia 2120i; 14.9 fL vs. 11.9 fL in XN-3000) with statistical significance (p < 0.001). PDW was elevated in ET in Advia 2120i (59.1%, p < 0.0001), but decreased in XN-3000 (10.0 fL, p < 0.001).
Conclusion
We analyzed the correlation of PDW values reported in Advia 2120i and XN-3000 for the first time, and showed that they are not compatible. PDW was affected by MPV in XN-3000, probably due to the calculation algorithm. PDW was elevated in ITP, suggesting the high proportion of large young platelets in this disease. However, the changes in PDW in ET were opposite in the two instruments, which requires further investigation.
Session topic: E-poster
Keyword(s): ITP, Platelet
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