FREQUENCY OF PLATELET FUNCTION DISORDERS IN PATIENTS PRESENTING WITH BLEEDING
(Abstract release date: 05/19/16)
EHA Library. Memon A. 06/09/16; 134972; PB2072
Dr. Ayesha Memon
Contributions
Contributions
Abstract
Abstract: PB2072
Type: Publication Only
Background
Inherited platelet function disorders may present with bleeding of variable severity and unknown frequency and may be frequently missed. They are increasingly recognized as an important cause of bleeding, particularly in adolescent girls with menorrhagia. The prevalence of congenital platelet disorders in our population has not been established, however, these disorders are relatively more common in communities where consanguineous marriages are more frequent like in the Middle East and India, but very limited information is available in developing countries like Pakistan about their prevalence so we attempted to assess the frequency of these disorders in our population.
Aims
Considering the higher prevalence of consanguineous marriages in Pakistani population, it is assumed that the incidence of platelet disorder must be higher. Therefore, the purpose of this study is to determine the frequency of platelet function disorders in patients presenting with bleeding. Previous studies conducted in Pakistan observed all causes of bleeding disorders like Haemoglobinopathies, von willebrand disease, Hemophilia & others, but our study specifically focused on platelet function disorders because these can lead to severe bleeding and are frequently missed.
Methods
Cross sectional study done between March to October 2014 at section of Haematology Aga Khan University Hospital. 5mlof whole blood sample in sodium citrate tube was collected for detection of platelet functions disorders. Platelet rich plasma was made by centrifugation and was used for testing. Platelet function studies were performed by using aggregation platelet aggregometer (Chrono-Log aggregometer model 700). ADP, Collagen, Epinephrine and Ristocitin were used as agonists.
Results
32 patients fulfilled inclusion criteria 18 females, 14 males with age range 3 years to 22 years. Out of these 32 patients 13 patients (40.62%) had platelet function disorder with female predominance ( 8 females, 5 males).Age ranges between 6 years to 22 years. Out of these 13 patients, 7 had Glanzmann’s- thrombasthenia, 4 had Bernard-Soulier syndrome & 2 patients were labeled with Quebec platelet disorder.
Conclusion
40% of these 32 patients had platelet function disorders. This is an ongoing study further data will be added on completion of specific period.
Session topic: E-poster
Keyword(s): Platelet aggregation
Type: Publication Only
Background
Inherited platelet function disorders may present with bleeding of variable severity and unknown frequency and may be frequently missed. They are increasingly recognized as an important cause of bleeding, particularly in adolescent girls with menorrhagia. The prevalence of congenital platelet disorders in our population has not been established, however, these disorders are relatively more common in communities where consanguineous marriages are more frequent like in the Middle East and India, but very limited information is available in developing countries like Pakistan about their prevalence so we attempted to assess the frequency of these disorders in our population.
Aims
Considering the higher prevalence of consanguineous marriages in Pakistani population, it is assumed that the incidence of platelet disorder must be higher. Therefore, the purpose of this study is to determine the frequency of platelet function disorders in patients presenting with bleeding. Previous studies conducted in Pakistan observed all causes of bleeding disorders like Haemoglobinopathies, von willebrand disease, Hemophilia & others, but our study specifically focused on platelet function disorders because these can lead to severe bleeding and are frequently missed.
Methods
Cross sectional study done between March to October 2014 at section of Haematology Aga Khan University Hospital. 5mlof whole blood sample in sodium citrate tube was collected for detection of platelet functions disorders. Platelet rich plasma was made by centrifugation and was used for testing. Platelet function studies were performed by using aggregation platelet aggregometer (Chrono-Log aggregometer model 700). ADP, Collagen, Epinephrine and Ristocitin were used as agonists.
Results
32 patients fulfilled inclusion criteria 18 females, 14 males with age range 3 years to 22 years. Out of these 32 patients 13 patients (40.62%) had platelet function disorder with female predominance ( 8 females, 5 males).Age ranges between 6 years to 22 years. Out of these 13 patients, 7 had Glanzmann’s- thrombasthenia, 4 had Bernard-Soulier syndrome & 2 patients were labeled with Quebec platelet disorder.
Conclusion
40% of these 32 patients had platelet function disorders. This is an ongoing study further data will be added on completion of specific period.
Session topic: E-poster
Keyword(s): Platelet aggregation
Abstract: PB2072
Type: Publication Only
Background
Inherited platelet function disorders may present with bleeding of variable severity and unknown frequency and may be frequently missed. They are increasingly recognized as an important cause of bleeding, particularly in adolescent girls with menorrhagia. The prevalence of congenital platelet disorders in our population has not been established, however, these disorders are relatively more common in communities where consanguineous marriages are more frequent like in the Middle East and India, but very limited information is available in developing countries like Pakistan about their prevalence so we attempted to assess the frequency of these disorders in our population.
Aims
Considering the higher prevalence of consanguineous marriages in Pakistani population, it is assumed that the incidence of platelet disorder must be higher. Therefore, the purpose of this study is to determine the frequency of platelet function disorders in patients presenting with bleeding. Previous studies conducted in Pakistan observed all causes of bleeding disorders like Haemoglobinopathies, von willebrand disease, Hemophilia & others, but our study specifically focused on platelet function disorders because these can lead to severe bleeding and are frequently missed.
Methods
Cross sectional study done between March to October 2014 at section of Haematology Aga Khan University Hospital. 5mlof whole blood sample in sodium citrate tube was collected for detection of platelet functions disorders. Platelet rich plasma was made by centrifugation and was used for testing. Platelet function studies were performed by using aggregation platelet aggregometer (Chrono-Log aggregometer model 700). ADP, Collagen, Epinephrine and Ristocitin were used as agonists.
Results
32 patients fulfilled inclusion criteria 18 females, 14 males with age range 3 years to 22 years. Out of these 32 patients 13 patients (40.62%) had platelet function disorder with female predominance ( 8 females, 5 males).Age ranges between 6 years to 22 years. Out of these 13 patients, 7 had Glanzmann’s- thrombasthenia, 4 had Bernard-Soulier syndrome & 2 patients were labeled with Quebec platelet disorder.
Conclusion
40% of these 32 patients had platelet function disorders. This is an ongoing study further data will be added on completion of specific period.
Session topic: E-poster
Keyword(s): Platelet aggregation
Type: Publication Only
Background
Inherited platelet function disorders may present with bleeding of variable severity and unknown frequency and may be frequently missed. They are increasingly recognized as an important cause of bleeding, particularly in adolescent girls with menorrhagia. The prevalence of congenital platelet disorders in our population has not been established, however, these disorders are relatively more common in communities where consanguineous marriages are more frequent like in the Middle East and India, but very limited information is available in developing countries like Pakistan about their prevalence so we attempted to assess the frequency of these disorders in our population.
Aims
Considering the higher prevalence of consanguineous marriages in Pakistani population, it is assumed that the incidence of platelet disorder must be higher. Therefore, the purpose of this study is to determine the frequency of platelet function disorders in patients presenting with bleeding. Previous studies conducted in Pakistan observed all causes of bleeding disorders like Haemoglobinopathies, von willebrand disease, Hemophilia & others, but our study specifically focused on platelet function disorders because these can lead to severe bleeding and are frequently missed.
Methods
Cross sectional study done between March to October 2014 at section of Haematology Aga Khan University Hospital. 5mlof whole blood sample in sodium citrate tube was collected for detection of platelet functions disorders. Platelet rich plasma was made by centrifugation and was used for testing. Platelet function studies were performed by using aggregation platelet aggregometer (Chrono-Log aggregometer model 700). ADP, Collagen, Epinephrine and Ristocitin were used as agonists.
Results
32 patients fulfilled inclusion criteria 18 females, 14 males with age range 3 years to 22 years. Out of these 32 patients 13 patients (40.62%) had platelet function disorder with female predominance ( 8 females, 5 males).Age ranges between 6 years to 22 years. Out of these 13 patients, 7 had Glanzmann’s- thrombasthenia, 4 had Bernard-Soulier syndrome & 2 patients were labeled with Quebec platelet disorder.
Conclusion
40% of these 32 patients had platelet function disorders. This is an ongoing study further data will be added on completion of specific period.
Session topic: E-poster
Keyword(s): Platelet aggregation
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