CLINICAL FEATURES OF LATENT / MASKED POLYCYTHEMIA VERA (SINGLE CENTER EXPERIENCE).
(Abstract release date: 05/19/16)
EHA Library. Soubortseva I. 06/09/16; 134931; PB2031
Dr. Irina Soubortseva
Contributions
Contributions
Abstract
Abstract: PB2031
Type: Publication Only
Background
Polycythemia vera is a heterogeneous group of diseases. In patients who don’t meet the World Health Organization (WHO) criteria for overt polycythaemia vera (PV), a diagnosis of latent / masked PV (mPV) can be determined. MPV is characterized by JAK2V617F positive, morphological features of bone marrow for PV according to WHO, but hemoglobin <18,5 g/dL in men and <16,5 g/dL in women.
Aims
The aim of this study was to identify clinical features of mPV as a separate group of PV.
Methods
The study included 81 patients observed in the outpatient department of National Research Center for Hematology from 2014 to 2015, 50 patients with PV and 31 patients with mPV.
Results
Distribution of patients by gender was statistically comparable. Patients with PV was older compared to mPV: median age was 56 and 44. Between the groups of patients with mPV and PV obvious difference in red blood cells (5.37 x 1012/L (4.1 - 6.5 x 1012/L) vs. 6.94 x 1012/L (5.4 - 8.8 x 1012/L)); hemoglobin (14,8 g/dL (10,0 – 16,7 g/dL) vs. 17,8 g/dL (13,6 – 24,7 g/dL)); hematocrit (45% (30 - 52%) vs. 53% (42 - 70%)). Median platelet counts higher in the group of patients with mPV compared with PV: the median was 644 x 109/L (179 - 1978 x 109/L) vs. 636 x 109/L (137 - 2437 x 109/L). Differences of white blood cells was not reveale in the two groups. All the patients were V617F JAK2 positive. Determination of allele burden JAK2V617F performed 29 patients with mPV and 37 patients with PV. JAK2 allele burden was significantly higher in patients with PV compared to mPV: median 14% (3 - 57%) and 55.5% (24 - 86%) respectively. Thrombosis revealed in 38% (12 patients) with mPV and in 16% (10 cases) in the PV. It was mainly venous in the case of mPV with a high frequency of splanchnic vein thrombosis. Arterial thrombosis detected only in 4 cases.
Conclusion
Masked PV is a separate nosological variant of PV.
Session topic: E-poster
Keyword(s): Polycythemia vera
Type: Publication Only
Background
Polycythemia vera is a heterogeneous group of diseases. In patients who don’t meet the World Health Organization (WHO) criteria for overt polycythaemia vera (PV), a diagnosis of latent / masked PV (mPV) can be determined. MPV is characterized by JAK2V617F positive, morphological features of bone marrow for PV according to WHO, but hemoglobin <18,5 g/dL in men and <16,5 g/dL in women.
Aims
The aim of this study was to identify clinical features of mPV as a separate group of PV.
Methods
The study included 81 patients observed in the outpatient department of National Research Center for Hematology from 2014 to 2015, 50 patients with PV and 31 patients with mPV.
Results
Distribution of patients by gender was statistically comparable. Patients with PV was older compared to mPV: median age was 56 and 44. Between the groups of patients with mPV and PV obvious difference in red blood cells (5.37 x 1012/L (4.1 - 6.5 x 1012/L) vs. 6.94 x 1012/L (5.4 - 8.8 x 1012/L)); hemoglobin (14,8 g/dL (10,0 – 16,7 g/dL) vs. 17,8 g/dL (13,6 – 24,7 g/dL)); hematocrit (45% (30 - 52%) vs. 53% (42 - 70%)). Median platelet counts higher in the group of patients with mPV compared with PV: the median was 644 x 109/L (179 - 1978 x 109/L) vs. 636 x 109/L (137 - 2437 x 109/L). Differences of white blood cells was not reveale in the two groups. All the patients were V617F JAK2 positive. Determination of allele burden JAK2V617F performed 29 patients with mPV and 37 patients with PV. JAK2 allele burden was significantly higher in patients with PV compared to mPV: median 14% (3 - 57%) and 55.5% (24 - 86%) respectively. Thrombosis revealed in 38% (12 patients) with mPV and in 16% (10 cases) in the PV. It was mainly venous in the case of mPV with a high frequency of splanchnic vein thrombosis. Arterial thrombosis detected only in 4 cases.
Conclusion
Masked PV is a separate nosological variant of PV.
Session topic: E-poster
Keyword(s): Polycythemia vera
Abstract: PB2031
Type: Publication Only
Background
Polycythemia vera is a heterogeneous group of diseases. In patients who don’t meet the World Health Organization (WHO) criteria for overt polycythaemia vera (PV), a diagnosis of latent / masked PV (mPV) can be determined. MPV is characterized by JAK2V617F positive, morphological features of bone marrow for PV according to WHO, but hemoglobin <18,5 g/dL in men and <16,5 g/dL in women.
Aims
The aim of this study was to identify clinical features of mPV as a separate group of PV.
Methods
The study included 81 patients observed in the outpatient department of National Research Center for Hematology from 2014 to 2015, 50 patients with PV and 31 patients with mPV.
Results
Distribution of patients by gender was statistically comparable. Patients with PV was older compared to mPV: median age was 56 and 44. Between the groups of patients with mPV and PV obvious difference in red blood cells (5.37 x 1012/L (4.1 - 6.5 x 1012/L) vs. 6.94 x 1012/L (5.4 - 8.8 x 1012/L)); hemoglobin (14,8 g/dL (10,0 – 16,7 g/dL) vs. 17,8 g/dL (13,6 – 24,7 g/dL)); hematocrit (45% (30 - 52%) vs. 53% (42 - 70%)). Median platelet counts higher in the group of patients with mPV compared with PV: the median was 644 x 109/L (179 - 1978 x 109/L) vs. 636 x 109/L (137 - 2437 x 109/L). Differences of white blood cells was not reveale in the two groups. All the patients were V617F JAK2 positive. Determination of allele burden JAK2V617F performed 29 patients with mPV and 37 patients with PV. JAK2 allele burden was significantly higher in patients with PV compared to mPV: median 14% (3 - 57%) and 55.5% (24 - 86%) respectively. Thrombosis revealed in 38% (12 patients) with mPV and in 16% (10 cases) in the PV. It was mainly venous in the case of mPV with a high frequency of splanchnic vein thrombosis. Arterial thrombosis detected only in 4 cases.
Conclusion
Masked PV is a separate nosological variant of PV.
Session topic: E-poster
Keyword(s): Polycythemia vera
Type: Publication Only
Background
Polycythemia vera is a heterogeneous group of diseases. In patients who don’t meet the World Health Organization (WHO) criteria for overt polycythaemia vera (PV), a diagnosis of latent / masked PV (mPV) can be determined. MPV is characterized by JAK2V617F positive, morphological features of bone marrow for PV according to WHO, but hemoglobin <18,5 g/dL in men and <16,5 g/dL in women.
Aims
The aim of this study was to identify clinical features of mPV as a separate group of PV.
Methods
The study included 81 patients observed in the outpatient department of National Research Center for Hematology from 2014 to 2015, 50 patients with PV and 31 patients with mPV.
Results
Distribution of patients by gender was statistically comparable. Patients with PV was older compared to mPV: median age was 56 and 44. Between the groups of patients with mPV and PV obvious difference in red blood cells (5.37 x 1012/L (4.1 - 6.5 x 1012/L) vs. 6.94 x 1012/L (5.4 - 8.8 x 1012/L)); hemoglobin (14,8 g/dL (10,0 – 16,7 g/dL) vs. 17,8 g/dL (13,6 – 24,7 g/dL)); hematocrit (45% (30 - 52%) vs. 53% (42 - 70%)). Median platelet counts higher in the group of patients with mPV compared with PV: the median was 644 x 109/L (179 - 1978 x 109/L) vs. 636 x 109/L (137 - 2437 x 109/L). Differences of white blood cells was not reveale in the two groups. All the patients were V617F JAK2 positive. Determination of allele burden JAK2V617F performed 29 patients with mPV and 37 patients with PV. JAK2 allele burden was significantly higher in patients with PV compared to mPV: median 14% (3 - 57%) and 55.5% (24 - 86%) respectively. Thrombosis revealed in 38% (12 patients) with mPV and in 16% (10 cases) in the PV. It was mainly venous in the case of mPV with a high frequency of splanchnic vein thrombosis. Arterial thrombosis detected only in 4 cases.
Conclusion
Masked PV is a separate nosological variant of PV.
Session topic: E-poster
Keyword(s): Polycythemia vera
{{ help_message }}
{{filter}}