ONLINE STREAMING YOGA IS A FEASIBLE NON-PHARMACOLOGIC MANAGEMENT STRATEGY IN MYELOPROLIFERATIVE NEOPLASM PATIENTS
(Abstract release date: 05/19/16)
EHA Library. Huberty J. 06/09/16; 134923; PB2023
Prof. Jennifer Huberty
Contributions
Contributions
Abstract
Abstract: PB2023
Type: Publication Only
Background
Up to 84% of Myeloproliferative Neoplasm (MPN) patients report a reduced overall quality of life (QoL). While MPN patients often experience an array of disease and treatment-related symptoms, fatigue is the most frequently reported symptom (93%). Yoga may be an effective approach to improving symptom burden (i.e., fatigue) and QoL in MPN patients based on evidence suggesting yoga may improve fatigue and QoL in other cancer types. (e.g., breast, endometrial).
Aims
To examine the feasibility (i.e., acceptability, demand, practicality) of a home-based, online-streamed yoga intervention in MPN patients. A secondary aim was to examine the effects of yoga on self-reported symptom burden and QoL outcomes.
Methods
MPN patients were recruited nationally using social media. Participants were asked to complete 60 minutes of online-streamed yoga per week and to complete online self-report surveys administered via Qualtrics (demographics, symptom burden (MPN-SAF TSS), and QoL (i.e., pain, anxiety, depression, sleep, sexual function via PROMIS). Surveys were administered at baseline (wk 1), mid-point (wk 7), and post-intervention (wk 12). Weekly yoga minutes were self- reported and collected weekly with adherence defined as achieving ≥60 min/wk.
Results
Patients: Two hundred and forty-four MPN patients completed the eligibility survey, 134 were eligible, 55 completed the informed consent and 38 participated in the 12-wk study. The most common reasons for ineligibility were a diagnosed mental illness (n=55) and already regularly performing mindful activity (n=46). Thirty patients had completed the intervention at the time of this analysis. Among those (N=30; mean age=55.8±9.2 years; mean BMI=25.0±4.4 kg/m2; 86.7% female), polycythemia vera was the most prevalent diagnosis (43.4%), followed by essential thrombocythemia (36.6%) and myelofibrosis (20.0%). The majority of participants were diagnosed >3 years ago (63.3%) and were JAKV617F positive (70%). Baseline measures were as follows: MPN-SAF TSS mean=34.6±14.0; Fatigue mean=6.6±2.5; Anxiety mean=51.9±7.0; Depression mean=47.5±7.6; Sleep mean=49.7±6.8.Yoga Participation & Safety: Just over 43% (13/30) of study participants averaged ≥60 min/wk of yoga. Overall yoga participation averaged 59.3±32.0 min/wk. Overall, 68% of participants were either satisfied (32%) or very satisfied (36%) with online yoga and 75% of participants agreed (46%) or strongly agreed (29%) that they felt safe from injury while practicing. Only one adverse event was reported (irritated enlarged spleen).Impact of Yoga Intervention: From baseline to post-intervention, there were significant improvements in self-reported symptom burden (MPN-SAF TSS mean reduction of 4.77±8.29; p=0.004), fatigue (MPN-SAF TSS mean reduction of 0.83±2.15; p=0.003), anxiety (PROMIS mean reduction of 5.02±7.97; p=0.002), depression (PROMIS mean reduction of 2.89±7.73; p=0.049), and sleep (PROMIS mean reduction of 3.76±3.60; p<0.001). When examining the differences between those that averaged <60 min/wk compared to those that averaged ≥60 min/wk, there were no significant differences in outcomes.
Conclusion
A 12-wk, home-based, online-streamed yoga intervention is feasible for MPN patients. Although the sample size of this study was small, this study suggests that online yoga may be effective for improving MPN related symptoms and self-reported QoL outcomes (i.e., anxiety, depression, sleep). Interestingly, outcomes were not significantly different between those that averaged <60 min/wk of yoga compared to those that averaged ≥60 min/wk of yoga. Future research should explore the minimal dose needed for improved symptom burden and QoL in MPN patients. Additionally, a randomized controlled trial with an active control group will help to determine the effectiveness of yoga for self-reported patient outcomes.
Session topic: E-poster
Keyword(s): Cancer, Health care, Myeloproliferative disorder, Treatment
Type: Publication Only
Background
Up to 84% of Myeloproliferative Neoplasm (MPN) patients report a reduced overall quality of life (QoL). While MPN patients often experience an array of disease and treatment-related symptoms, fatigue is the most frequently reported symptom (93%). Yoga may be an effective approach to improving symptom burden (i.e., fatigue) and QoL in MPN patients based on evidence suggesting yoga may improve fatigue and QoL in other cancer types. (e.g., breast, endometrial).
Aims
To examine the feasibility (i.e., acceptability, demand, practicality) of a home-based, online-streamed yoga intervention in MPN patients. A secondary aim was to examine the effects of yoga on self-reported symptom burden and QoL outcomes.
Methods
MPN patients were recruited nationally using social media. Participants were asked to complete 60 minutes of online-streamed yoga per week and to complete online self-report surveys administered via Qualtrics (demographics, symptom burden (MPN-SAF TSS), and QoL (i.e., pain, anxiety, depression, sleep, sexual function via PROMIS). Surveys were administered at baseline (wk 1), mid-point (wk 7), and post-intervention (wk 12). Weekly yoga minutes were self- reported and collected weekly with adherence defined as achieving ≥60 min/wk.
Results
Patients: Two hundred and forty-four MPN patients completed the eligibility survey, 134 were eligible, 55 completed the informed consent and 38 participated in the 12-wk study. The most common reasons for ineligibility were a diagnosed mental illness (n=55) and already regularly performing mindful activity (n=46). Thirty patients had completed the intervention at the time of this analysis. Among those (N=30; mean age=55.8±9.2 years; mean BMI=25.0±4.4 kg/m2; 86.7% female), polycythemia vera was the most prevalent diagnosis (43.4%), followed by essential thrombocythemia (36.6%) and myelofibrosis (20.0%). The majority of participants were diagnosed >3 years ago (63.3%) and were JAKV617F positive (70%). Baseline measures were as follows: MPN-SAF TSS mean=34.6±14.0; Fatigue mean=6.6±2.5; Anxiety mean=51.9±7.0; Depression mean=47.5±7.6; Sleep mean=49.7±6.8.Yoga Participation & Safety: Just over 43% (13/30) of study participants averaged ≥60 min/wk of yoga. Overall yoga participation averaged 59.3±32.0 min/wk. Overall, 68% of participants were either satisfied (32%) or very satisfied (36%) with online yoga and 75% of participants agreed (46%) or strongly agreed (29%) that they felt safe from injury while practicing. Only one adverse event was reported (irritated enlarged spleen).Impact of Yoga Intervention: From baseline to post-intervention, there were significant improvements in self-reported symptom burden (MPN-SAF TSS mean reduction of 4.77±8.29; p=0.004), fatigue (MPN-SAF TSS mean reduction of 0.83±2.15; p=0.003), anxiety (PROMIS mean reduction of 5.02±7.97; p=0.002), depression (PROMIS mean reduction of 2.89±7.73; p=0.049), and sleep (PROMIS mean reduction of 3.76±3.60; p<0.001). When examining the differences between those that averaged <60 min/wk compared to those that averaged ≥60 min/wk, there were no significant differences in outcomes.
Conclusion
A 12-wk, home-based, online-streamed yoga intervention is feasible for MPN patients. Although the sample size of this study was small, this study suggests that online yoga may be effective for improving MPN related symptoms and self-reported QoL outcomes (i.e., anxiety, depression, sleep). Interestingly, outcomes were not significantly different between those that averaged <60 min/wk of yoga compared to those that averaged ≥60 min/wk of yoga. Future research should explore the minimal dose needed for improved symptom burden and QoL in MPN patients. Additionally, a randomized controlled trial with an active control group will help to determine the effectiveness of yoga for self-reported patient outcomes.
Session topic: E-poster
Keyword(s): Cancer, Health care, Myeloproliferative disorder, Treatment
Abstract: PB2023
Type: Publication Only
Background
Up to 84% of Myeloproliferative Neoplasm (MPN) patients report a reduced overall quality of life (QoL). While MPN patients often experience an array of disease and treatment-related symptoms, fatigue is the most frequently reported symptom (93%). Yoga may be an effective approach to improving symptom burden (i.e., fatigue) and QoL in MPN patients based on evidence suggesting yoga may improve fatigue and QoL in other cancer types. (e.g., breast, endometrial).
Aims
To examine the feasibility (i.e., acceptability, demand, practicality) of a home-based, online-streamed yoga intervention in MPN patients. A secondary aim was to examine the effects of yoga on self-reported symptom burden and QoL outcomes.
Methods
MPN patients were recruited nationally using social media. Participants were asked to complete 60 minutes of online-streamed yoga per week and to complete online self-report surveys administered via Qualtrics (demographics, symptom burden (MPN-SAF TSS), and QoL (i.e., pain, anxiety, depression, sleep, sexual function via PROMIS). Surveys were administered at baseline (wk 1), mid-point (wk 7), and post-intervention (wk 12). Weekly yoga minutes were self- reported and collected weekly with adherence defined as achieving ≥60 min/wk.
Results
Patients: Two hundred and forty-four MPN patients completed the eligibility survey, 134 were eligible, 55 completed the informed consent and 38 participated in the 12-wk study. The most common reasons for ineligibility were a diagnosed mental illness (n=55) and already regularly performing mindful activity (n=46). Thirty patients had completed the intervention at the time of this analysis. Among those (N=30; mean age=55.8±9.2 years; mean BMI=25.0±4.4 kg/m2; 86.7% female), polycythemia vera was the most prevalent diagnosis (43.4%), followed by essential thrombocythemia (36.6%) and myelofibrosis (20.0%). The majority of participants were diagnosed >3 years ago (63.3%) and were JAKV617F positive (70%). Baseline measures were as follows: MPN-SAF TSS mean=34.6±14.0; Fatigue mean=6.6±2.5; Anxiety mean=51.9±7.0; Depression mean=47.5±7.6; Sleep mean=49.7±6.8.Yoga Participation & Safety: Just over 43% (13/30) of study participants averaged ≥60 min/wk of yoga. Overall yoga participation averaged 59.3±32.0 min/wk. Overall, 68% of participants were either satisfied (32%) or very satisfied (36%) with online yoga and 75% of participants agreed (46%) or strongly agreed (29%) that they felt safe from injury while practicing. Only one adverse event was reported (irritated enlarged spleen).Impact of Yoga Intervention: From baseline to post-intervention, there were significant improvements in self-reported symptom burden (MPN-SAF TSS mean reduction of 4.77±8.29; p=0.004), fatigue (MPN-SAF TSS mean reduction of 0.83±2.15; p=0.003), anxiety (PROMIS mean reduction of 5.02±7.97; p=0.002), depression (PROMIS mean reduction of 2.89±7.73; p=0.049), and sleep (PROMIS mean reduction of 3.76±3.60; p<0.001). When examining the differences between those that averaged <60 min/wk compared to those that averaged ≥60 min/wk, there were no significant differences in outcomes.
Conclusion
A 12-wk, home-based, online-streamed yoga intervention is feasible for MPN patients. Although the sample size of this study was small, this study suggests that online yoga may be effective for improving MPN related symptoms and self-reported QoL outcomes (i.e., anxiety, depression, sleep). Interestingly, outcomes were not significantly different between those that averaged <60 min/wk of yoga compared to those that averaged ≥60 min/wk of yoga. Future research should explore the minimal dose needed for improved symptom burden and QoL in MPN patients. Additionally, a randomized controlled trial with an active control group will help to determine the effectiveness of yoga for self-reported patient outcomes.
Session topic: E-poster
Keyword(s): Cancer, Health care, Myeloproliferative disorder, Treatment
Type: Publication Only
Background
Up to 84% of Myeloproliferative Neoplasm (MPN) patients report a reduced overall quality of life (QoL). While MPN patients often experience an array of disease and treatment-related symptoms, fatigue is the most frequently reported symptom (93%). Yoga may be an effective approach to improving symptom burden (i.e., fatigue) and QoL in MPN patients based on evidence suggesting yoga may improve fatigue and QoL in other cancer types. (e.g., breast, endometrial).
Aims
To examine the feasibility (i.e., acceptability, demand, practicality) of a home-based, online-streamed yoga intervention in MPN patients. A secondary aim was to examine the effects of yoga on self-reported symptom burden and QoL outcomes.
Methods
MPN patients were recruited nationally using social media. Participants were asked to complete 60 minutes of online-streamed yoga per week and to complete online self-report surveys administered via Qualtrics (demographics, symptom burden (MPN-SAF TSS), and QoL (i.e., pain, anxiety, depression, sleep, sexual function via PROMIS). Surveys were administered at baseline (wk 1), mid-point (wk 7), and post-intervention (wk 12). Weekly yoga minutes were self- reported and collected weekly with adherence defined as achieving ≥60 min/wk.
Results
Patients: Two hundred and forty-four MPN patients completed the eligibility survey, 134 were eligible, 55 completed the informed consent and 38 participated in the 12-wk study. The most common reasons for ineligibility were a diagnosed mental illness (n=55) and already regularly performing mindful activity (n=46). Thirty patients had completed the intervention at the time of this analysis. Among those (N=30; mean age=55.8±9.2 years; mean BMI=25.0±4.4 kg/m2; 86.7% female), polycythemia vera was the most prevalent diagnosis (43.4%), followed by essential thrombocythemia (36.6%) and myelofibrosis (20.0%). The majority of participants were diagnosed >3 years ago (63.3%) and were JAKV617F positive (70%). Baseline measures were as follows: MPN-SAF TSS mean=34.6±14.0; Fatigue mean=6.6±2.5; Anxiety mean=51.9±7.0; Depression mean=47.5±7.6; Sleep mean=49.7±6.8.Yoga Participation & Safety: Just over 43% (13/30) of study participants averaged ≥60 min/wk of yoga. Overall yoga participation averaged 59.3±32.0 min/wk. Overall, 68% of participants were either satisfied (32%) or very satisfied (36%) with online yoga and 75% of participants agreed (46%) or strongly agreed (29%) that they felt safe from injury while practicing. Only one adverse event was reported (irritated enlarged spleen).Impact of Yoga Intervention: From baseline to post-intervention, there were significant improvements in self-reported symptom burden (MPN-SAF TSS mean reduction of 4.77±8.29; p=0.004), fatigue (MPN-SAF TSS mean reduction of 0.83±2.15; p=0.003), anxiety (PROMIS mean reduction of 5.02±7.97; p=0.002), depression (PROMIS mean reduction of 2.89±7.73; p=0.049), and sleep (PROMIS mean reduction of 3.76±3.60; p<0.001). When examining the differences between those that averaged <60 min/wk compared to those that averaged ≥60 min/wk, there were no significant differences in outcomes.
Conclusion
A 12-wk, home-based, online-streamed yoga intervention is feasible for MPN patients. Although the sample size of this study was small, this study suggests that online yoga may be effective for improving MPN related symptoms and self-reported QoL outcomes (i.e., anxiety, depression, sleep). Interestingly, outcomes were not significantly different between those that averaged <60 min/wk of yoga compared to those that averaged ≥60 min/wk of yoga. Future research should explore the minimal dose needed for improved symptom burden and QoL in MPN patients. Additionally, a randomized controlled trial with an active control group will help to determine the effectiveness of yoga for self-reported patient outcomes.
Session topic: E-poster
Keyword(s): Cancer, Health care, Myeloproliferative disorder, Treatment
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